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This study aimed to compare the phenotypic features of familial Crohn\u2019s disease (CD) with sporadic CD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Familial CD was defined as CD patients having one or more first, second, third, fourth degree, or above relatives with CD. Sporadic CD patients hospitalized during the same period were matched 1:3 by age and gender. Differences in clinical characteristics, phenotype distribution, extraintestinal manifestations, and complications at diagnosis, as well as treatment regimen and surgery, were compared between familial and sporadic CD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The familial CD was associated with a higher rate of past appendectomy history (<jats:italic>P<\/jats:italic>\u2009=\u20090.009), more intestinal perforation at onset (<jats:italic>P<\/jats:italic>\u2009=\u20090.012), more MRI results of anal lesion (<jats:italic>P<\/jats:italic>\u2009=\u20090.023), and gastrointestinal perforation (<jats:italic>P<\/jats:italic>\u2009=\u20090.040) at diagnosis, higher rate of past intestinal surgery history (<jats:italic>P<\/jats:italic>\u2009=\u20090.007), more number of intestinal surgeries (<jats:italic>P<\/jats:italic>\u2009=\u20090.037), longer duration of follow-up (<jats:italic>P<\/jats:italic>\u2009=\u20090.017), lower rate of taking biologicals for current maintenance (<jats:italic>P<\/jats:italic>\u2009=\u20090.043), lower tendency to upgrade to biologicals during follow-up (<jats:italic>P<\/jats:italic>\u2009=\u20090.013), higher possibility to experience gastrointestinal obstruction (<jats:italic>P<\/jats:italic>\u2009=\u20090.047), and abdominal abscess during follow-up (<jats:italic>P<\/jats:italic>\u2009=\u20090.045).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Familial CD is associated with a more aggressive clinical phenotype.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00384-024-04688-7","type":"journal-article","created":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T08:01:46Z","timestamp":1720857706000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Differences of clinical phenotype between familial and sporadic Crohn\u2019s disease in East China"],"prefix":"10.1007","volume":"39","author":[{"given":"Siyuan","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongbei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingna","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,13]]},"reference":[{"issue":"2","key":"4688_CR1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.5217\/ir.2016.14.2.111","volume":"14","author":"WK Ng","year":"2016","unstructured":"Ng WK, Wong SH, Ng SC (2016) Changing epidemiological trends of inflammatory bowel disease in Asia. 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