{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:40:53Z","timestamp":1790800853182,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004505","name":"Universit\u00e0 degli Studi di Catania","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004505","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>In this article, we aim to demonstrate that thyroid carcinoma can metastasize to the small bowel. This case report involves a 66-year-old woman who underwent total thyroidectomy surgery in 2019, with histopathology revealing a 3A undifferentiated thyroid cancer. She presented with symptoms of bowel obstruction, including abdominal pain, nausea, and vomiting. Thyroid carcinoma accounts for less than 4% of all malignant neoplasms, making it the most common endocrine malignancy. The predominant type is papillary carcinoma, which generally has a favorable prognosis. In contrast, poorly differentiated thyroid cancers have a poor prognosis, with a 5-year postoperative survival rate of 66%. Common metastatic sites include the lungs, brain, and bones, with rare occurrences in organs such as the kidneys, spleen, adrenal glands, and ovaries. Intestinal metastases are extremely rare, with fewer than 15 cases of gastrointestinal localization documented in the literature. This case highlights the rare possibility of thyroid carcinoma metastasizing to the small bowel, emphasizing the need for clinicians to consider metastatic spread in patients with a history of thyroid cancer who present with gastrointestinal symptoms.<\/jats:p>","DOI":"10.1007\/s00384-025-04804-1","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T15:00:05Z","timestamp":1737558005000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Isolated metastasis of the bowel from undifferentiated thyroid carcinoma. A case report and a literature review"],"prefix":"10.1007","volume":"40","author":[{"given":"Mariacristina","family":"Cartillone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Sarv\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Mazzone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Litrico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carolina","family":"Picardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Saverio","family":"Latteri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"La Greca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"issue":"1","key":"4804_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ecl.2018.10.002","volume":"48","author":"CD Seib","year":"2019","unstructured":"Seib CD, Sosa JA (2019) Evolving understanding of the epidemiology of thyroid cancer. Endocrinol Metab Clin North Am 48(1):23\u201335. https:\/\/doi.org\/10.1016\/j.ecl.2018.10.002","journal-title":"Endocrinol Metab Clin North Am"},{"key":"4804_CR2","unstructured":"Townsend CM ,Beauchamp RD, Evers BM, Mattox KL (2019) Sabiston. Trattato di chirurgia, p 36"},{"issue":"1","key":"4804_CR3","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1146\/annurev-med-061512-105739","volume":"65","author":"T Carling","year":"2014","unstructured":"Carling T, Udelsman R (2014) Thyroid cancer. Annu Rev Med 65(1):125\u2013137. https:\/\/doi.org\/10.1146\/annurev-med-061512-105739","journal-title":"Annu Rev Med"},{"issue":"1","key":"4804_CR4","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.nic.2012.08.010","volume":"23","author":"AM Saindane","year":"2013","unstructured":"Saindane AM (2013) Pitfalls in the staging of cancer of thyroid. Neuroimaging Clin N Am 23(1):123\u2013145. https:\/\/doi.org\/10.1016\/j.nic.2012.08.010","journal-title":"Neuroimaging Clin N Am"},{"issue":"5","key":"4804_CR5","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1002\/cncr.20087","volume":"100","author":"M Volante","year":"2004","unstructured":"Volante M, Landolfi S, Chiusa L, Palestini N, Motta M, Codegone A, Torchio B, Papotti MG (2004) Poorly differentiated carcinomas of the thyroid with trabecular, insular, and solid patterns: a clinicopathologic study of 183 patients. Cancer 100(5):950\u2013957. https:\/\/doi.org\/10.1002\/cncr.20087","journal-title":"Cancer"},{"issue":"4","key":"4804_CR6","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1210\/jcem.86.4.7407","volume":"86","author":"EL Mazzaferri","year":"2001","unstructured":"Mazzaferri EL, Kloos RT (2001) Current approaches to primary therapy for papillary and follicular thyroid cancer. J Clin Endocrinol Metab 86(4):1447\u20131463","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"4804_CR7","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1210\/jcem.80.7.7608252","volume":"80","author":"SF Dinneen","year":"1995","unstructured":"Dinneen SF, Valimaki MJ, Bergstralh EJ, Goellner JR, Gorman CA, Hay ID (1995) Distant metastases in papillary thyroid carcinoma: 100 cases observed at one institution during 5 decades. J Clin Endocrinol Metab 80(7):2041\u20132045. https:\/\/doi.org\/10.1210\/jcem.80.7.7608252","journal-title":"J Clin Endocrinol Metab"},{"key":"4804_CR8","doi-asserted-by":"publisher","unstructured":"Namwongprom S, N\u00fa\u00f1ez RF, Yeung HW, Kim EE, Macapinlac HA (2007) Unusual adrenal metastasis and abdominal carcinomatosis secondary to Hurthle cell carcinoma of the thyroid. Exp Clin Endocrinol Diabetes 115(10):694\u20136. https:\/\/doi.org\/10.1055\/s-2007-985361","DOI":"10.1055\/s-2007-985361"},{"issue":"8","key":"4804_CR9","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1089\/10507250152484664","volume":"11","author":"RC Smallridge","year":"2001","unstructured":"Smallridge RC, Castro MR, Morris JC, Young PR, Reynolds JC, Merino MJ, Sarlis NJ (2001) Renal metastases from thyroid papillary carcinoma: study of sodium iodide symporter expression. Thyroid 11(8):795\u2013804. https:\/\/doi.org\/10.1089\/10507250152484664","journal-title":"Thyroid"},{"issue":"6","key":"4804_CR10","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1159\/000326660","volume":"47","author":"E Mayayo","year":"2003","unstructured":"Mayayo E, Bl\u00e1zquez S, G\u00f3mez-Aracil V, Saur\u00ed A, Martinez S (2003) Spleen metastasis from thyroid carcinoma. Acta Cytol 47(6):1116\u20131118. https:\/\/doi.org\/10.1159\/000326660","journal-title":"Acta Cytol"},{"issue":"2","key":"4804_CR11","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/00004347-199404000-00012","volume":"13","author":"RH Young","year":"1994","unstructured":"Young RH, Jackson A, Wells M (1994) Ovarian metastasis from thyroid carcinoma 12 years after partial thyroidectomy mimicking struma ovarii: report of a case. Int J Gynecol Pathol 13(2):181\u2013185. https:\/\/doi.org\/10.1097\/00004347-199404000-00012","journal-title":"Int J Gynecol Pathol"},{"issue":"11","key":"4804_CR12","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1089\/105072501753271789","volume":"11","author":"S Logani","year":"2001","unstructured":"Logani S, Baloch ZW, Snyder PJ, Weinstein R, LiVolsi VA (2001) Cystic ovarian metastasis from papillary thyroid carcinoma: a case report. Thyroid 11(11):1073\u20131075. https:\/\/doi.org\/10.1089\/105072501753271789","journal-title":"Thyroid"},{"issue":"06","key":"4804_CR13","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1055\/s-2007-973853","volume":"115","author":"S Brogioni","year":"2007","unstructured":"Brogioni S, Viacava P, Tomisti L, Martino E, Macchia E (2007) A special case of bilateral ovarian metastases in a woman with papillary carcinoma of the thyroid. Exp Clin Endocrinol Diabetes 115(06):397\u2013400. https:\/\/doi.org\/10.1055\/s-2007-973853","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"09","key":"4804_CR14","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1055\/s-2002-33876","volume":"40","author":"D Bandorski","year":"2002","unstructured":"Bandorski D, Arps H, Jaspersen D, Diehl KL (2002) Severe intestinal bleeding caused by intestinal metastases of a primary angiosarcoma of the thyroid gland. Z. F\u00c3\u00bcr Gastroenterol 40(09):811\u2013814. https:\/\/doi.org\/10.1055\/s-2002-33876","journal-title":"Z. F\u00c3\u00bcr Gastroenterol"},{"issue":"5","key":"4804_CR15","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1089\/thy.2009.0019","volume":"19","author":"GY Meyer-Rochow","year":"2009","unstructured":"Meyer-Rochow GY, McMullen TP, Gill AJ, Sywak MS, Robinson BG (2009) Intra-abdominal insular thyroid carcinoma metastasis. Thyroid 19(5):527\u2013530. https:\/\/doi.org\/10.1089\/thy.2009.0019","journal-title":"Thyroid"},{"issue":"1","key":"4804_CR16","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s40792-015-0066-9","volume":"1","author":"M Kobayashi","year":"2015","unstructured":"Kobayashi M, Itabashi H, Ikeda T, Yamazaki N, Kaji T, Takagane A (2015) Simultaneous occurrence of distant metastases to the small intestine and the thoracic esophagus from anaplastic thyroid carcinoma: a case report. Surg Case Rep 1(1):63. https:\/\/doi.org\/10.1186\/s40792-015-0066-9","journal-title":"Surg Case Rep"},{"issue":"1","key":"4804_CR17","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s40792-020-00959-x","volume":"6","author":"K Hosoda","year":"2020","unstructured":"Hosoda K, Kusama K, Yanagisawa N, Machida T, Nishio A, Nakata S, Ito I, Watanabe M, Sodeyama H (2020) Anaplastic transformation of thyroid cancer in mesentery metastases presenting as intestinal perforation: a case report. Surg Case Rep 6(1):194. https:\/\/doi.org\/10.1186\/s40792-020-00959-x","journal-title":"Surg Case Rep"},{"key":"4804_CR18","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2021.255","volume":"11","author":"J Hrudka","year":"2021","unstructured":"Hrudka J, Vadlenkov\u00e1 I (2021) Small bowel perforation and death caused by anaplastic thyroid carcinoma metastasis in a patient with concomitant colonic and bilateral breast carcinoma. Autopsy Case Rep 11:e2021255. https:\/\/doi.org\/10.4322\/acr.2021.255","journal-title":"Autopsy Case Rep"},{"issue":"1","key":"4804_CR19","first-page":"63","volume":"77","author":"L Ricciardelli","year":"2006","unstructured":"Ricciardelli L, Rapicano G, Pinto A, Napolitano G, Feleppa C, Martino G, Martino A (2006) Small bowel intussusception caused by metastasis from anaplastic thyroid carcinoma: case report and literature review. Ann Ital Chir 77(1):63\u201367","journal-title":"Ann Ital Chir"},{"key":"4804_CR20","doi-asserted-by":"publisher","unstructured":"Phillips DL, Benner KG, Keeffe EB, Traweek ST (1987) Isolated metastasis to small bowel from anaplastic thyroid carcinoma. With a review of extra-abdominal malignancies that spread to the bowel. J Clin Gastroenterol 9(5):563\u20137. https:\/\/doi.org\/10.1097\/00004836-198710000-00017","DOI":"10.1097\/00004836-198710000-00017"},{"issue":"4","key":"4804_CR21","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1089\/thy.2009.0280","volume":"20","author":"J Klubo-Gwiezdzinska","year":"2010","unstructured":"Klubo-Gwiezdzinska J, Morowitz D, Van Nostrand D, Burman KD, Vasko V, Soberman M, Wartofsky L (2010) Metastases of well-differentiated thyroid cancer to the gastrointestinal system. Thyroid 20(4):381\u2013387. https:\/\/doi.org\/10.1089\/thy.2009.0280","journal-title":"Thyroid"},{"issue":"4","key":"4804_CR22","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/S0149-7944(03)00061-8","volume":"60","author":"ML Richards","year":"2003","unstructured":"Richards ML, Schwesinger WH, Fowler L (2003) Rectal bleeding in a woman with a thyroid mass. Curr Surg 60(4):428\u2013430. https:\/\/doi.org\/10.1016\/S0149-7944(03)00061-8","journal-title":"Curr Surg"},{"issue":"5","key":"4804_CR23","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1097\/MED.0000000000000189","volume":"22","author":"R Ranganath","year":"2015","unstructured":"Ranganath R, Shah MA, Shah AR (2015) Anaplastic thyroid cancer. Curr Opin Endocrinol Diabetes Obes 22(5):387\u2013391. https:\/\/doi.org\/10.1097\/MED.0000000000000189","journal-title":"Curr Opin Endocrinol Diabetes Obes"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-025-04804-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00384-025-04804-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-025-04804-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T15:00:10Z","timestamp":1737558010000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00384-025-04804-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,22]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4804"],"URL":"https:\/\/doi.org\/10.1007\/s00384-025-04804-1","relation":{},"ISSN":["1432-1262"],"issn-type":[{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,22]]},"assertion":[{"value":"2 January 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23"}}