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Angioleiomyoma in the hindgut is infrequent and in particular, rectal\/perianal location has been observed very rarely.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case report<\/jats:title>\n            <jats:p>We describe herein a case of a 50-year-old male patient complaining of perineal discomfort and a swelling at the level of the left ischio-rectal fossa, moderately painful. This solid mass in the left ischio-rectal space was in close relationship with the wall of the ano-rectal junction. After surgical removal and histopathology, the mass resulted an angioleiomyoma, vascular type, desmin positive, a very rare neoplasm. Extensive immune-histochemical studies are fundamental for the correct diagnosis and to rule out other mesenchymal tumors.<\/jats:p>\n            <jats:p>Discussion\/conclusion.<\/jats:p>\n            <jats:p>Angioleiomyoma is a very rare neoplasm of the gastrointestinal tract, and the fundamental problem of peri-rectal\/perianal angioleiomyoma is represented by differential diagnosis from gastrointestinal stromal tumors (GISTs) and other perianal\/perirectal swellings. For correct differential diagnosis, the histopathology supported by extensive immune-histochemical study adopting a panel of specific tissue markers is important. The surgical treatment is mandatory with complete excision and subsequent follow-up since local recurrence may occur.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00384-025-04836-7","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T17:53:50Z","timestamp":1740419630000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Angioleiomyoma originating from the ano-rectal wall presenting as a perineal mass: a case report"],"prefix":"10.1007","volume":"40","author":[{"given":"Sayali","family":"Valiyeva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Cicerone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Iacobelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina R.","family":"Quaglione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Pietroletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"4836_CR1","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1111\/j.1365-4632.2012.05628.x","volume":"51","author":"YA Chen","year":"2012","unstructured":"Chen YA, Chuang WY, Hsueh S, Chan KC (2012) Solitary nodule on the auricle. 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