{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:54:15Z","timestamp":1789181655566,"version":"build-2803163510"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universitat de Valencia"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the relevance of peritoneal reflection involvement in long-term oncological outcomes in patients with rectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective observational study from a specialized colorectal unit that included a consecutive series of patients undergoing mesorectal excision for rectal cancer. Peritoneal reflection (PR) involvement was evaluated on pathological examination using Shepherd\u2019s classification. Overall survival (OS), disease-free survival (DFS), and local recurrence (LR) were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred sixty patients were included in the present analysis. Peritoneal involvement was present in 28.2% of the 85 tumors above or at the level of PR. There were no differences in OS, DFS, or LR according to tumor\u2019s height location. The 5-year OS, DFS, and LR for tumors involving PR were 58.3%, 61.7%, and 30.3%, respectively. Patients with peritoneal involvement had a higher LR rate (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and shorter OS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). Shepherd\u2019s grade 4 peritoneal involvement was an independent risk factor for OS (HR 2.9; 95% CI 1.1\u20139.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) and LR (HR 4.2; 95% CI 1.2\u201316.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>After rectal cancer resection, peritoneal involvement is an independent risk factor for local recurrence and poor survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00384-025-04909-7","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T10:21:05Z","timestamp":1746872465000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Peritoneal reflection involvement as a prognostic factor in rectal cancer. Long-term oncological outcomes from a prospective study"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1389-7892","authenticated-orcid":false,"given":"Eduardo","family":"Alvarez-Sarrado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4753-1832","authenticated-orcid":false,"given":"Matteo","family":"Frasson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4151-1782","authenticated-orcid":false,"given":"Jorge","family":"Sancho-Muriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5757-0691","authenticated-orcid":false,"given":"Maria Jose","family":"Gomez-Jurado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8049-2521","authenticated-orcid":false,"given":"Hanna","family":"Cholewa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6659-5391","authenticated-orcid":false,"given":"Vicent","family":"Primo-Romaguera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5321-1432","authenticated-orcid":false,"given":"Monica","family":"Millan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3508-6492","authenticated-orcid":false,"given":"Adela","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2395-6350","authenticated-orcid":false,"given":"Polina","family":"Rudenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3399-9477","authenticated-orcid":false,"given":"Blas","family":"Flor-Lorente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2657-6852","authenticated-orcid":false,"given":"Eduardo","family":"Garcia-Granero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0765-7120","authenticated-orcid":false,"given":"Francisco","family":"Giner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"key":"4909_CR1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/codi.12849","volume":"17","author":"C Debove","year":"2015","unstructured":"Debove C, Maggiori L, Chau A, Kanso F, Ferron M, Panis Y (2015) What happens after R1 resection in patients undergoing laparoscopic total mesorectal excision for rectal cancer? A study in 333 consecutive patients. Colorectal Dis 17:197\u2013204. https:\/\/doi.org\/10.1111\/codi.12849","journal-title":"Colorectal Dis"},{"key":"4909_CR2","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1111\/j.1463-1318.2010.02249.x","volume":"13","author":"E Garc\u00eda-Granero","year":"2011","unstructured":"Garc\u00eda-Granero E, Faiz O, Flor-Lorente B, Garc\u00eda-Botello S, Escl\u00e1pez P, Cervantes A (2011) Prognostic implications of circumferential location of distal rectal cancer. Colorectal Dis 13:650\u2013657. https:\/\/doi.org\/10.1111\/j.1463-1318.2010.02249.x","journal-title":"Colorectal Dis"},{"key":"4909_CR3","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1002\/bjs.7458","volume":"98","author":"FG Taylor","year":"2011","unstructured":"Taylor FG, Quirke P, Heald RJ, Moran B, Blomqvist L, Swift I, St Rose S, Sebag-Montefiore DJ, Tekkis P, Brown G, MERCURY study group, (2011) One millimetre is the safe cut-off for magnetic resonance imaging prediction of surgical margin status in rectal cancer. Br J Surg 98:872\u2013879. https:\/\/doi.org\/10.1002\/bjs.7458","journal-title":"Br J Surg"},{"key":"4909_CR4","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1200\/JCO.2007.12.7027","volume":"26","author":"ID Nagtegaal","year":"2008","unstructured":"Nagtegaal ID, Quirke P (2008) What is the role for the circumferential margin in the modern treatment of rectal cancer? J Clin Oncol 26:303\u2013312. https:\/\/doi.org\/10.1200\/JCO.2007.12.7027","journal-title":"J Clin Oncol"},{"key":"4909_CR5","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1200\/JCO.2012.45.3258","volume":"32","author":"Taylor FG, Quirke P, Heald RJ, Moran BJ, Blomqvist L, Swift IR, Sebag-Montefiore D, Tekkis P, Brown G; Magnetic Resonance Imaging in Rectal Cancer European Equivalence Study Study Group","year":"2014","unstructured":"Taylor FG, Quirke P, Heald RJ, Moran BJ, Blomqvist L, Swift IR, Sebag-Montefiore D, Tekkis P, Brown G; Magnetic Resonance Imaging in Rectal Cancer European Equivalence Study Study Group (2014) Preoperative magnetic resonance imaging assessment of circumferential resection margin predicts disease-free survival and local recurrence: 5-year follow-up results of the MERCURY study. J Clin Oncol 32:34\u201343. https:\/\/doi.org\/10.1200\/JCO.2012.45.3258","journal-title":"J Clin Oncol"},{"key":"4909_CR6","unstructured":"Loughrey MB, Quirke P, Shepherd NA (2023) Standards and datasets for reporting cancers. Dataset for histopathological reporting of colorectal cancer. The Royal College of Pathologist. Available from: https:\/\/www.rcpath.org\/resourceLibrary\/g049-dataset-for-histopathological-reporting-of-colorectal-cancer.html"},{"key":"4909_CR7","doi-asserted-by":"publisher","first-page":"e549","DOI":"10.1097\/SLA.0000000000005051","volume":"275","author":"MB Loughrey","year":"2022","unstructured":"Loughrey MB, Webster F, Arends MJ, Brown I, Burgart LJ, Cunningham C, Flejou JF, Kakar S, Kirsch R, Kojima M, Lugli A, Rosty C, Sheahan K, West NP, Wilson RH, Nagtegaal ID (2022) Dataset for pathology reporting of colorectal cancer: recommendations from the International Collaboration on Cancer Reporting (ICCR). Ann Surg 275:e549\u2013e561. https:\/\/doi.org\/10.1097\/SLA.0000000000005051","journal-title":"Ann Surg"},{"key":"4909_CR8","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1097\/DCR.0000000000000349","volume":"58","author":"FG Marinello","year":"2015","unstructured":"Marinello FG, Frasson M, Baguena G, Flor-Lorente B, Cervantes A, Rosell\u00f3 S, Esp\u00ed A, Garc\u00eda-Granero E (2015) Selective approach for upper rectal cancer treatment: total mesorectal excision and preoperative chemoradiation are seldom necessary. Dis Colon Rectum 58:556\u2013565. https:\/\/doi.org\/10.1097\/DCR.0000000000000349","journal-title":"Dis Colon Rectum"},{"key":"4909_CR9","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1002\/bjs.10879","volume":"105","author":"R Ruppert","year":"2018","unstructured":"Ruppert R, Junginger T, Ptok H, Strassburg J, Maurer CA, Brosi P, Sauer J, Baral J, Kreis M, Wollschlaeger D, Hermanek P, Merkel S, OCUM group, (2018) Oncological outcome after MRI-based selection for neoadjuvant chemoradiotherapy in the OCUM Rectal Cancer Trial. Br J Surg 105:1519\u20131529. https:\/\/doi.org\/10.1002\/bjs.10879","journal-title":"Br J Surg"},{"key":"4909_CR10","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1097\/SLA.0b013e31820b8d52","volume":"253","author":"FG Taylor","year":"2011","unstructured":"Taylor FG, Quirke P, Heald RJ, Moran B, Blomqvist L, Swift I, Sebag-Montefiore DJ, Tekkis P, Brown G, MERCURY study group, (2011) Preoperative high-resolution magnetic resonance imaging can identify good prognosis stage I, II, and III rectal cancer best managed by surgery alone: a prospective, multicenter, European study. Ann Surg 253:711\u2013719. https:\/\/doi.org\/10.1097\/SLA.0b013e31820b8d52","journal-title":"Ann Surg"},{"key":"4909_CR11","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1002\/bjs.8679","volume":"99","author":"J Segelman","year":"2012","unstructured":"Segelman J, Granath F, Holm T, Machado M, Mahteme H, Martling A (2012) Incidence, prevalence and risk factors for peritoneal carcinomatosis from colorectal cancer. Br J Surg 99:699\u2013705. https:\/\/doi.org\/10.1002\/bjs.8679","journal-title":"Br J Surg"},{"key":"4909_CR12","doi-asserted-by":"publisher","first-page":"183","DOI":"10.5114\/wiitm.2011.34205","volume":"8","author":"J Kenig","year":"2013","unstructured":"Kenig J, Richter P (2013) Definition of the rectum and level of the peritoneal reflection - still a matter of debate? Wideochir Inne Tech Maloinwazyjne 8:183\u2013186. https:\/\/doi.org\/10.5114\/wiitm.2011.34205","journal-title":"Wideochir Inne Tech Maloinwazyjne"},{"key":"4909_CR13","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/codi.13219","volume":"18","author":"J Segelman","year":"2016","unstructured":"Segelman J, Akre O, Gustafsson UO, Bottai M, Martling A (2016) External validation of models predicting the individual risk of metachronous peritoneal carcinomatosis from colon and rectal cancer. Colorectal Dis 18:378\u2013385. https:\/\/doi.org\/10.1111\/codi.13219","journal-title":"Colorectal Dis"},{"issue":"13","key":"4909_CR14","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.3390\/cancers13092135","volume":"28","author":"V Granata","year":"2021","unstructured":"Granata V, Caruso D, Grassi R, Cappabianca S, Reginelli A, Rizzati R, Masselli G, Golfieri R, Rengo M, Regge D, Lo Re G, Pradella S, Fusco R, Faggioni L, Laghi A, Miele V, Neri E, Coppola F (2021) Structured reporting of rectal cancer staging and restaging: a consensus proposal. Cancers (Basel) 28(13):2135. https:\/\/doi.org\/10.3390\/cancers13092135","journal-title":"Cancers (Basel)"},{"key":"4909_CR15","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3390\/cancers15010165","volume":"15","author":"A Sommariva","year":"2022","unstructured":"Sommariva A, Tonello M, Coccolini F, De Manzoni G, Delrio P, Pizzolato E, Gelmini R, Serra F, Rreka E, Pasqual EM, Marano L, Biacchi D, Carboni F, Kusamura S, Sammartino P (2022) Colorectal cancer with peritoneal metastases: the impact of the results of PROPHYLOCHIP, COLOPEC, and PRODIGE 7 trials on peritoneal disease management. Cancers (Basel) 15:165. https:\/\/doi.org\/10.3390\/cancers15010165","journal-title":"Cancers (Basel)"},{"key":"4909_CR16","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/bjs.4034","volume":"90","author":"G Brown","year":"2003","unstructured":"Brown G, Radcliffe AG, Newcombe RG, Dallimore NS, Bourne MW, Williams GT (2003) Preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imaging. Br J Surg 90:355\u2013364. https:\/\/doi.org\/10.1002\/bjs.4034","journal-title":"Br J Surg"},{"key":"4909_CR17","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1007\/s00330-017-5026-2","volume":"28","author":"RGH Beets-Tan","year":"2018","unstructured":"Beets-Tan RGH, Lambregts DMJ, Maas M, Bipat S, Barbaro B, Curvo-Semedo L, Fenlon HM, Gollub MJ, Gourtsoyianni S, Halligan S, Hoeffel C, Kim SH, Laghi A, Maier A, Rafaelsen SR, Stoker J, Taylor SA, Torkzad MR, Blomqvist L (2018) Magnetic resonance imaging for clinical management of rectal cancer: updated recommendations from the 2016 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus meeting. Eur Radiol 28:1465\u20131475. https:\/\/doi.org\/10.1007\/s00330-017-5026-2","journal-title":"Eur Radiol"},{"key":"4909_CR18","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/bjs.9355","volume":"101","author":"DS Keller","year":"2014","unstructured":"Keller DS, Paspulati R, Kjellmo A, Rokseth KM, Bankwitz B, Wibe A, Delaney CP (2014) MRI-defined height of rectal tumours. Br J Surg 101:127\u2013132. https:\/\/doi.org\/10.1002\/bjs.9355","journal-title":"Br J Surg"},{"key":"4909_CR19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/sj.bjc.6601871","volume":"91","author":"G Brown","year":"2004","unstructured":"Brown G, Davies S, Williams GT, Bourne MW, Newcombe RG, Radcliffe AG, Blethyn J, Dallimore NS, Rees BI, Phillips CJ, Maughan TS (2004) Effectiveness of preoperative staging in rectal cancer: digital rectal examination, endoluminal ultrasound or magnetic resonance imaging? Br J Cancer 91:23\u201329. https:\/\/doi.org\/10.1038\/sj.bjc.6601871","journal-title":"Br J Cancer"},{"key":"4909_CR20","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3748\/wjg.v21.i2.423","volume":"21","author":"S Alasari","year":"2015","unstructured":"Alasari S, Lim D, Kim NK (2015) Magnetic resonance imaging based rectal cancer classification: landmarks and technical standardization. World J Gastroenterol 21:423\u2013431. https:\/\/doi.org\/10.3748\/wjg.v21.i2.423","journal-title":"World J Gastroenterol"},{"key":"4909_CR21","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.clinimag.2017.11.012","volume":"50","author":"S Srisajjakul","year":"2018","unstructured":"Srisajjakul S, Prapaisilp P, Bangchokdee S (2018) Pitfalls in MRI of rectal cancer: what radiologists need to know and avoid. Clin Imaging 50:130\u2013140. https:\/\/doi.org\/10.1016\/j.clinimag.2017.11.012","journal-title":"Clin Imaging"},{"issue":"4","key":"4909_CR22","doi-asserted-by":"publisher","first-page":"iv22","DOI":"10.1093\/annonc\/mdx224","volume":"28","author":"R GlynneGlynne-Jones","year":"2017","unstructured":"GlynneGlynne-Jones R, Wyrwicz L, Tiret E, Brown G, R\u00f6del C, Cervantes A, Arnold D, Guidelines Committee ESMO (2017) Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 28(4):iv22\u2013iv40. https:\/\/doi.org\/10.1093\/annonc\/mdx224","journal-title":"Ann Oncol"},{"issue":"8","key":"4909_CR23","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1002\/bjs.4296","volume":"90","author":"MG Tytherleigh","year":"2003","unstructured":"Tytherleigh MG, McC Mortensen NJ (2003) Options for sphincter preservation in surgery for low rectal cancer. Br J Surg 90(8):922\u2013933. https:\/\/doi.org\/10.1002\/bjs.4296","journal-title":"Br J Surg"},{"key":"4909_CR24","doi-asserted-by":"publisher","unstructured":"\u00c1lvarez Sarrado E, Giner Segura F, Batista Domenech A, Garcia-Granero Garc\u00eda-Fuster \u00c1, Frasson M, Rudenko P, Flor Lorente B, Garcia-Granero Xim\u00e9nez E (2021) Rectal cancer at the peritoneal reflection. Preoperative MRI accuracy and histophatologic correlation. Prospective study. Cir Esp (Engl Ed) 12:S0009\u2013739X(21)00157\u20133. English, Spanish. https:\/\/doi.org\/10.1016\/j.ciresp.2021.04.009.","DOI":"10.1016\/j.ciresp.2021.04.009"},{"key":"4909_CR25","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1136\/jcp.48.9.849","volume":"48","author":"NA Shepherd","year":"1995","unstructured":"Shepherd NA, Baxter KJ, Love SB (1995) Influence of local peritoneal involvement on pelvic recurrence and prognosis in rectal cancer. J Clin Pathol 48:849\u2013855. https:\/\/doi.org\/10.1136\/jcp.48.9.849","journal-title":"J Clin Pathol"},{"key":"4909_CR26","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1111\/j.1365-2559.2010.03687.x.-9","volume":"57","author":"JR Mitchard","year":"2010","unstructured":"Mitchard JR, Love SB, Baxter KJ, Shepherd NA (2010) How important is peritoneal involvement in rectal cancer? A prospective study of 331 cases. Histopathology 57:671\u2013679. https:\/\/doi.org\/10.1111\/j.1365-2559.2010.03687.x.-9","journal-title":"Histopathology"},{"issue":"5","key":"4909_CR27","doi-asserted-by":"publisher","first-page":"v198","DOI":"10.1093\/annonc\/mdz246.001","volume":"30","author":"D Morton","year":"2019","unstructured":"Morton D (2019) FOxTROT: an international randomised controlled trial in 1053 patients evaluating neoadjuvant chemotherapy (NAC) for colon cancer. On behalf of the FOxTROT Collaborative Group. Ann Oncol 30(5):v198. https:\/\/doi.org\/10.1093\/annonc\/mdz246.001","journal-title":"Ann Oncol"},{"key":"4909_CR28","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/j.1365-2559.2005.02189.x","volume":"47","author":"L Ludeman","year":"2005","unstructured":"Ludeman L, Shepherd NA (2005) Serosal involvement in gastrointestinal cancer: its assessment and significance. Histopathology 47:123\u2013131. https:\/\/doi.org\/10.1111\/j.1365-2559.2005.02189.x","journal-title":"Histopathology"},{"key":"4909_CR29","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1111\/j.1463-1318.2006.01136.x","volume":"9","author":"A Keshava","year":"2007","unstructured":"Keshava A, Chapuis PH, Chan C, Lin BP, Bokey EL, Dent OF (2007) The significance of involvement of a free serosal surface for recurrence and survival following resection of clinicopathological stage B and C rectal cancer. Colorectal Dis 9:609\u2013618. https:\/\/doi.org\/10.1111\/j.1463-1318.2006.01136.x","journal-title":"Colorectal Dis"},{"key":"4909_CR30","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1097\/DCR.0000000000001358","volume":"62","author":"J Fang","year":"2019","unstructured":"Fang J, Zheng Z, Wei H (2019) Reconsideration of the anterior surgical plane of total mesorectal excision for rectal cancer. Dis Colon Rectum 62:639\u2013641. https:\/\/doi.org\/10.1097\/DCR.0000000000001358","journal-title":"Dis Colon Rectum"},{"key":"4909_CR31","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002889","volume":"95","author":"S Yiqun","year":"2016","unstructured":"Yiqun S, Tong T, Fangqi L, Sanjun C, Chao X, Yajia G, Ye X (2016) Recognition of anterior peritoneal reflections and their relationship with rectal tumors using rectal magnetic resonance imaging. Medicine (Baltimore) 95:e2889. https:\/\/doi.org\/10.1097\/MD.0000000000002889","journal-title":"Medicine (Baltimore)"},{"key":"4909_CR32","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1097\/CM9.0000000000002024","volume":"135","author":"X Wang","year":"2022","unstructured":"Wang X, Zheng Z, Chen M, Lin J, Lu X, Huang Y, Huang S, Chi P (2022) Morphology of the anterior mesorectum: a new predictor for local recurrence in patients with rectal cancer. Chin Med J (Engl) 135:2453\u20132460. https:\/\/doi.org\/10.1097\/CM9.0000000000002024","journal-title":"Chin Med J (Engl)"},{"key":"4909_CR33","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1007\/s00261-018-1642-9","volume":"43","author":"MJ Gollub","year":"2018","unstructured":"Gollub MJ, Arya S, Beets-Tan RG, dePrisco G, Gonen M, Jhaveri K, Kassam Z, Kaur H, Kim D, Knezevic A, Korngold E, Lall C, Lalwani N, Blair Macdonald D, Moreno C, Nougaret S, Pickhardt P, Sheedy S, Harisinghani M (2018) Use of magnetic resonance imaging in rectal cancer patients: Society of Abdominal Radiology (SAR) rectal cancer disease-focused panel (DFP) recommendations 2017. Abdom Radiol (NY) 43:2893\u20132902. https:\/\/doi.org\/10.1007\/s00261-018-1642-9","journal-title":"Abdom Radiol (NY)"},{"key":"4909_CR34","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1111\/j.1463-1318.2008.01700.x","volume":"11","author":"Sigurdsson HK, K\u00f8rner H, Dahl O, Skarstein A, S\u00f8reide JA; Norwegian Colorectal Cancer Group","year":"2009","unstructured":"Sigurdsson HK, K\u00f8rner H, Dahl O, Skarstein A, S\u00f8reide JA; Norwegian Colorectal Cancer Group (2009) Rectal cancer with macroscopic peritoneal involvement\u2013clinical challenges and consequences. Colorectal Dis 11:838\u2013844. https:\/\/doi.org\/10.1111\/j.1463-1318.2008.01700.x","journal-title":"Colorectal Dis"},{"key":"4909_CR35","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1200\/JCO.22.00046","volume":"41","author":"Morton D, Seymour M, Magill L, Handley K, Glasbey J, Glimelius B, Palmer A, Seligmann J, Laurberg S, Murakami K, West N, Quirke P, Gray R; FOxTROT Collaborative Group","year":"2023","unstructured":"Morton D, Seymour M, Magill L, Handley K, Glasbey J, Glimelius B, Palmer A, Seligmann J, Laurberg S, Murakami K, West N, Quirke P, Gray R; FOxTROT Collaborative Group (2023) Preoperative chemotherapy for operable colon cancer: mature results of an international randomized controlled trial. J Clin Oncol 41:1541\u20131552. https:\/\/doi.org\/10.1200\/JCO.22.00046","journal-title":"J Clin Oncol"},{"key":"4909_CR36","doi-asserted-by":"publisher","unstructured":"Hu H, Zhang J, Li Y, Wang X, Wang Z, Wang H, Kang L, Liu P, Lan P, Wu X, Zhen Y, Pei H, Huang Z, Zhang H, Chen W, Zeng Y, Lai J, Wei H, Huang X, Chen J, Chen J, Tao K, Xu Q, Peng X, Liang J, Cai G, Ding K, Ding Z, Hu M, Zhang W, Tang B, Hong C, Cao J, Huang Z, Cao W, Li F, Wang X, Wang C, Huang Y, Zhao Y, Cai Y, Ling J, Xie X, Wu Z, Shi L, Ling L, Liu H, Wang J, Huang M, Deng Y; OPTICAL study group (2024) Neoadjuvant chemotherapy with oxaliplatin and fluoropyrimidine versus upfront surgery for locally advanced colon cancer: the randomized, phase III OPTICAL trial. J Clin Oncol 2:JCO2301889. https:\/\/doi.org\/10.1200\/JCO.23.01889.","DOI":"10.1200\/JCO.23.01889"},{"key":"4909_CR37","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1111\/codi.16908","volume":"26","author":"J Arredondo","year":"2024","unstructured":"Arredondo J, Almeida A, Casta\u00f1\u00f3n C, S\u00e1nchez C, Villafa\u00f1e A, Tejedor P, Sim\u00f3 V, Baixauli J, Rodr\u00edguez J, Pastor C (2024) The ELECLA trial: a multicentre randomised control trial on outcomes of neoadjuvant treatment on locally advanced colon cancer. Colorectal Dis 26:745\u2013753. https:\/\/doi.org\/10.1111\/codi.16908","journal-title":"Colorectal Dis"},{"key":"4909_CR38","doi-asserted-by":"crossref","unstructured":"Nougaret S, Jhaveri K, Kassam Z, Lall C, Kim DH. Rectal cancer MR staging: pearls and pitfalls at baseline examination. Abdom Radiol (NY) 44:3536\u20133548","DOI":"10.1007\/s00261-019-02024-0"},{"key":"4909_CR39","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2214\/AJR.11.7602","volume":"200","author":"MJ Gollub","year":"2013","unstructured":"Gollub MJ, Maas M, Weiser M, Beets GL, Goodman K, Berkers L, Beets-Tan RG (2013) Recognition of the anterior peritoneal reflection at rectal MRI. AJR Am J Roentgenol 200:97\u2013101. https:\/\/doi.org\/10.2214\/AJR.11.7602","journal-title":"AJR Am J Roentgenol"},{"key":"4909_CR40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220533","volume":"14","author":"Y Zhao","year":"2019","unstructured":"Zhao Y, Yi C, Zhang Y, Fang F, Faramand A (2019) Intensive follow-up strategies after radical surgery for non-metastatic colorectal cancer: a systematic review and meta-analysis of randomized controlled trials. PLoS ONE 14:e0220533. https:\/\/doi.org\/10.1371\/journal.pone.0220533","journal-title":"PLoS ONE"},{"key":"4909_CR41","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/S2468-1253(19)30239-0","volume":"4","author":"CEL Klaver","year":"2019","unstructured":"Klaver CEL, Wisselink DD, Punt CJA, Snaebjornsson P, Crezee J, Aalbers AGJ, Brandt A, Bremers AJA, Burger JWA, Fabry HFJ, Ferenschild F, Festen S, van Grevenstein WMU, Hemmer PHJ, de Hingh IHJT, Kok NFM, Musters GD, Schoonderwoerd L, Tuynman JB, van de Ven AWH, van Westreenen HL, Wiezer MJ, Zimmerman DDE, van Zweeden AA, Dijkgraaf MGW, Tanis PJ, COLOPEC collaborators group, (2019) Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): a multicentre, open-label, randomised trial. Lancet Gastroenterol Hepatol 4:761\u2013770. https:\/\/doi.org\/10.1016\/S2468-1253(19)30239-0","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"4909_CR42","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/S1470-2045(20)30322-3","volume":"21","author":"D Go\u00e9r\u00e9","year":"2020","unstructured":"Go\u00e9r\u00e9 D, Glehen O, Quenet F, Guilloit JM, Bereder JM, Lorimier G, Thibaudeau E, Ghouti L, Pinto A, Tuech JJ, Kianmanesh R, Carretier M, Marchal F, Arvieux C, Brigand C, Meeus P, Rat P, Durand-Fontanier S, Mariani P, Lakkis Z, Loi V, Pirro N, Sabbagh C, Texier M, Elias D, BIG-RENAPE group, (2020) Second-look surgery plus hyperthermic intraperitoneal chemotherapy versus surveillance in patients at high risk of developing colorectal peritoneal metastases (PROPHYLOCHIP-PRODIGE 15): a randomised, phase 3 study. Lancet Oncol 21:1147\u20131154. https:\/\/doi.org\/10.1016\/S1470-2045(20)30322-3","journal-title":"Lancet Oncol"},{"key":"4909_CR43","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1001\/jamasurg.2023.0662","volume":"158","author":"A Arjona-S\u00e1nchez","year":"2023","unstructured":"Arjona-S\u00e1nchez A, Espinosa-Redondo E, Guti\u00e9rrez-Calvo A, Segura-Sampedro JJ, P\u00e9rez-Viejo E, Concepci\u00f3n-Mart\u00edn V, S\u00e1nchez-Garc\u00eda S, Garc\u00eda-Fadrique A, Prieto-Nieto I, Barrios-Sanchez P, Torres-Melero J, Ram\u00edrez Faraco M, Prada-Villaverde A, Carrasco-Campos J, Artiles-Armas M, Villarejo-Campos P, Ortega-P\u00e9rez G, Boldo-Roda E, S\u00e1nchez-Hidalgo JM, Casado-Adam A, Rodr\u00edguez-Ortiz L, Aranda E, Cano-Osuna MT, D\u00edaz-L\u00f3pez C, Romero-Ruiz A, Brice\u00f1o-Delgado J, Rufi\u00e1n-Pe\u00f1a S, Espa\u00f1ol G, de Carcinomatosis Peritoneal, (2023) Efficacy and safety of intraoperative hyperthermic intraperitoneal chemotherapy for locally advanced colon cancer: a phase 3 randomized clinical trial. JAMA Surg 158:683\u2013691. https:\/\/doi.org\/10.1001\/jamasurg.2023.0662","journal-title":"JAMA Surg"},{"key":"4909_CR44","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1016\/j.acra.2019.04.005","volume":"26","author":"SA Ahmed","year":"2019","unstructured":"Ahmed SA, Abou-Taleb H, Yehia A, El Malek NAA, Siefeldein GS, Badary DM, Jabir MA (2019) The accuracy of multi-detector computed tomography and laparoscopy in the prediction of peritoneal carcinomatosis index score in primary ovarian cancer. Acad Radiol 26:1650\u20131658. https:\/\/doi.org\/10.1016\/j.acra.2019.04.005","journal-title":"Acad Radiol"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-025-04909-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00384-025-04909-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-025-04909-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T10:21:08Z","timestamp":1746872468000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00384-025-04909-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,10]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4909"],"URL":"https:\/\/doi.org\/10.1007\/s00384-025-04909-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6297876\/v1","asserted-by":"object"}]},"ISSN":["1432-1262"],"issn-type":[{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,10]]},"assertion":[{"value":"2 May 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"114"}}