{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:42:32Z","timestamp":1793032952684,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"DOI":"10.1007\/s00384-025-04926-6","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T20:36:52Z","timestamp":1748983012000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Right extended hemicolectomy with ileo-descending anastomosis is associated with prolonged postoperative ileus and longer hospital stay compared to right or left hemicolectomy"],"prefix":"10.1007","volume":"40","author":[{"given":"Shani Y.","family":"Parnasa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Shweiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Pinhasov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samer","family":"Abu Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Gefen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ido","family":"Mizrahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Abu-Gazala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon J.","family":"Pikarsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6167-109X","authenticated-orcid":false,"given":"Noam","family":"Shussman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"4926_CR1","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1007\/s11605-013-2148-y","volume":"17","author":"R Vather","year":"2013","unstructured":"Vather R, Trivedi S, Bissett I (2013) Defining postoperative ileus: Results of a systematic review and global survey. J Gastrointest Surgery 17:962\u2013972. https:\/\/doi.org\/10.1007\/s11605-013-2148-y","journal-title":"J Gastrointest Surgery"},{"key":"4926_CR2","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.clnu.2015.01.016","volume":"34","author":"D Bragg","year":"2015","unstructured":"Bragg D, El-Sharkawy A, Psaltis E, Maxwell-Armstrong CA, Lobo DN (2015) Postoperative ileus: Recent developments in pathophysiology and management. Clin Nutr 34:367\u2013376. https:\/\/doi.org\/10.1016\/j.clnu.2015.01.016","journal-title":"Clin Nutr"},{"key":"4926_CR3","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00268-011-1339-5","volume":"36","author":"M Millan","year":"2012","unstructured":"Millan M, Biondo S, Fraccalvieri D, Frago R, Golda T, Kreisler E (2012) Risk factors for prolonged postoperative ileus after colorectal cancer surgery. World J Surg 36:179\u2013185. https:\/\/doi.org\/10.1007\/s00268-011-1339-5","journal-title":"World J Surg"},{"key":"4926_CR4","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/1440-1681.12220","volume":"41","author":"R Vather","year":"2014","unstructured":"Vather R, O\u2019Grady G, Bissett IP, Dinning PG (2014) Postoperative ileus: mechanisms and future directions for research. Clin Exp Pharmacol Physiol 41:358\u2013370. https:\/\/doi.org\/10.1111\/1440-1681.12220","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"4926_CR5","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/nrgastro.2012.134","volume":"9","author":"SHW van Bree","year":"2012","unstructured":"van Bree SHW, Nemethova A, Cailotto C, Gomez-Pinilla PJ, Matteoli G, Boeckxstaens GE (2012) New therapeutic strategies for postoperative ileus. Nat Rev Gastroenterol Hepatol 9:675\u2013683. https:\/\/doi.org\/10.1038\/nrgastro.2012.134","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"4926_CR6","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1111\/nmo.12584","volume":"27","author":"TR Glowka","year":"2015","unstructured":"Glowka TR, Steinebach A, Stein K et al (2015) The novel CGRP receptor antagonist BIBN4096BS alleviates a postoperative intestinal inflammation and prevents postoperative ileus. Neurogastroenterol Motil 27:1038\u20131049. https:\/\/doi.org\/10.1111\/nmo.12584","journal-title":"Neurogastroenterol Motil"},{"key":"4926_CR7","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1007\/s00268-008-9491-2","volume":"32","author":"A Artinyan","year":"2008","unstructured":"Artinyan A, Nunoo-Mensah JW, Balasubramaniam S et al (2008) Prolonged postoperative ileus-definition, risk factors, and predictors after surgery. World J Surg 32:1495\u20131500. https:\/\/doi.org\/10.1007\/s00268-008-9491-2","journal-title":"World J Surg"},{"key":"4926_CR8","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1097\/DCR.0000000000001301","volume":"62","author":"H Mao","year":"2019","unstructured":"Mao H, Milne TGE, O\u2019Grady G, Vather R, Edlin R, Bissett I (2019) Prolonged postoperative ileus significantly increases the cost of inpatient stay for patients undergoing elective colorectal surgery: Results of a multivariate analysis of prospective data at a single institution. Dis Colon Rectum 62:631\u2013637. https:\/\/doi.org\/10.1097\/DCR.0000000000001301","journal-title":"Dis Colon Rectum"},{"key":"4926_CR9","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1007\/s11605-015-2877-1","volume":"19","author":"SE Tevis","year":"2015","unstructured":"Tevis SE, Carchman EH, Foley EF, Harms BA, Heise CP, Kennedy GD (2015) Postoperative ileus-more than just prolonged length of stay? J Gastrointest Surg 19:1684\u20131690. https:\/\/doi.org\/10.1007\/s11605-015-2877-1","journal-title":"J Gastrointest Surg"},{"key":"4926_CR10","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/BF01537233","volume":"35","author":"EH Livingston","year":"1990","unstructured":"Livingston EH, Passaro EP Jr (1990) Postoperative ileus. Dig Dis Sci 35:121\u2013132. https:\/\/doi.org\/10.1007\/BF01537233","journal-title":"Dig Dis Sci"},{"key":"4926_CR11","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/s0002-9610(85)80100-8","volume":"149","author":"WP Morgan","year":"1985","unstructured":"Morgan WP, Jenkins N, Lewis P, Aubrey DA (1985) Management of obstructing carcinoma of the left colon by extended right hemicolectomy. Am J Surg 149:327\u2013329. https:\/\/doi.org\/10.1016\/s0002-9610(85)80100-8","journal-title":"Am J Surg"},{"key":"4926_CR12","doi-asserted-by":"publisher","first-page":"5304","DOI":"10.1007\/s00464-019-07318-4","volume":"34","author":"R Garfinkle","year":"2020","unstructured":"Garfinkle R, Al-Rashid F, Morin N et al (2020) Are right-sided colectomies for neoplastic disease at increased risk of primary postoperative ileus compared to left-sided colectomies? A coarsened exact matched analysis. Surg Endosc 34:5304\u20135311. https:\/\/doi.org\/10.1007\/s00464-019-07318-4","journal-title":"Surg Endosc"},{"key":"4926_CR13","doi-asserted-by":"publisher","first-page":"E242","DOI":"10.1111\/ans.13823","volume":"88","author":"L Yuan","year":"2018","unstructured":"Yuan L, O\u2019Grady G, Milne T, Jaung R, Vather R, Bissett IP (2018) Prospective comparison of return of bowel function after left versus right colectomy. ANZ J Surg 88:E242\u2013E247. https:\/\/doi.org\/10.1111\/ans.13823","journal-title":"ANZ J Surg"},{"key":"4926_CR14","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1111\/codi.14543","volume":"21","author":"F Grass","year":"2019","unstructured":"Grass F, Lovely JK, Crippa J et al (2019) Comparison of recovery and outcome after left and right colectomy. Colorectal Dis 21:481\u2013486. https:\/\/doi.org\/10.1111\/codi.14543","journal-title":"Colorectal Dis"},{"key":"4926_CR15","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1111\/codi.12932","volume":"17","author":"F Phillips","year":"2015","unstructured":"Phillips F, Muls AC, Lalji A, Andreyev HJN (2015) Are bile acid malabsorption and bile acid diarrhea an important cause of diarrhea complicating cancer therapy? Colorectal Dis 17:730\u2013734. https:\/\/doi.org\/10.1111\/codi.12932","journal-title":"Colorectal Dis"},{"key":"4926_CR16","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/BF02238251","volume":"41","author":"KW Eu","year":"1998","unstructured":"Eu KW, Lim SL, Seow-Choen F, Leong AF, Ho YH (1998) Clinical outcome and bowel function following total abdominal colectomy and ileorectal anastomosis in the Oriental population. Dis Colon Rectum 41:215\u2013218. https:\/\/doi.org\/10.1007\/BF02238251","journal-title":"Dis Colon Rectum"},{"key":"4926_CR17","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1016\/j.clinthera.2009.11.027","volume":"31","author":"L Wedlake","year":"2009","unstructured":"Wedlake L, Thomas K, Lalji A, Anagnostopoulos C, Andreyev HJN (2009) Effectiveness and tolerability of colesevelam hydrochloride for bile-acid malabsorption in patients with cancer: a retrospective chart review and patient questionnaire. Clin Ther 31:2549\u20132558. https:\/\/doi.org\/10.1016\/j.clinthera.2009.11.027","journal-title":"Clin Ther"},{"key":"4926_CR18","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1159\/000088704","volume":"51","author":"DA Elphick","year":"2005","unstructured":"Elphick DA, Chew TS, Higham SE, Bird N, Ahmad A, Sanders DS (2005) Small bowel bacterial overgrowth in symptomatic older people: can it be diagnosed earlier? Gerontology 51:396\u2013401. https:\/\/doi.org\/10.1159\/000088704","journal-title":"Gerontology"},{"key":"4926_CR19","doi-asserted-by":"publisher","first-page":"818","DOI":"10.3109\/00365521.2011.574728","volume":"46","author":"M Kurien","year":"2011","unstructured":"Kurien M, Evans KE, Leeds JS, Hopper AD, Harris A, Sanders DS (2011) Bile acid malabsorption: an under-investigated differential diagnosis in patients presenting with diarrhea predominant irritable bowel syndrome type symptoms. Scand J Gastroenterol 46:818\u2013822. https:\/\/doi.org\/10.3109\/00365521.2011.574728","journal-title":"Scand J Gastroenterol"},{"key":"4926_CR20","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/SLA.0b013e3181b13ca2","volume":"250","author":"PA Clavien","year":"2009","unstructured":"Clavien PA, Barkun J, de Oliveira ML et al (2009) The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg 250:187\u2013196. https:\/\/doi.org\/10.1097\/SLA.0b013e3181b13ca2","journal-title":"Ann Surg"},{"key":"4926_CR21","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.surg.2009.10.012","volume":"147","author":"NN Rahbari","year":"2010","unstructured":"Rahbari NN, Weitz J, Hohenberger W et al (2010) Definition and grading of anastomotic leakage following anterior resection of the rectum: a proposal by the International Study Group of Rectal Cancer. Surgery 147:339\u2013351. https:\/\/doi.org\/10.1016\/j.surg.2009.10.012","journal-title":"Surgery"},{"key":"4926_CR22","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1007\/s00595-013-0803-2","volume":"44","author":"M Odermatt","year":"2014","unstructured":"Odermatt M, Siddiqi N, Johns R et al (2014) Short- and long-term outcomes for patients with splenic flexure tumours treated by left versus extended right colectomy are comparable: a retrospective analysis. Surg Today 44:2045\u20132051. https:\/\/doi.org\/10.1007\/s00595-013-0803-2","journal-title":"Surg Today"},{"key":"4926_CR23","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1308\/rcsann.2016.0112","volume":"98","author":"G Gravante","year":"2016","unstructured":"Gravante G, Elshaer M, Parker R et al (2016) Extended right hemicolectomy and left hemicolectomy for colorectal cancers between the distal transverse and proximal descending colon. Ann R Coll Surg Engl 98:303\u2013307. https:\/\/doi.org\/10.1308\/rcsann.2016.0112","journal-title":"Ann R Coll Surg Engl"},{"key":"4926_CR24","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1007\/s00384-015-2469-2","volume":"31","author":"de\u2019Angelis N, Hain E, Disabato M,","year":"2016","unstructured":"de\u2019Angelis N, Hain E, Disabato M, et al (2016) Laparoscopic extended right colectomy versus laparoscopic left colectomy for carcinoma of the splenic flexure: a matched case-control study. Int J Colorectal Dis 31:623\u2013630. https:\/\/doi.org\/10.1007\/s00384-015-2469-2","journal-title":"Int J Colorectal Dis"},{"key":"4926_CR25","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.amjsurg.2017.06.035","volume":"216","author":"M Beisani","year":"2018","unstructured":"Beisani M, Vallribera F, Garc\u00eda A et al (2018) Subtotal colectomy versus left hemicolectomy for the elective treatment of splenic flexure colonic neoplasia. Am J Surg 216:251\u2013254. https:\/\/doi.org\/10.1016\/j.amjsurg.2017.06.035","journal-title":"Am J Surg"},{"key":"4926_CR26","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00384-020-03763-z","volume":"36","author":"X Wang","year":"2020","unstructured":"Wang X, Zheng Z, Chen M et al (2020) Subtotal colectomy, extended right hemicolectomy, left hemicolectomy, or splenic flexure colectomy for splenic flexure tumors: a network meta-analysis. Int J Colorectal Dis 36:311\u2013322. https:\/\/doi.org\/10.1007\/s00384-020-03763-z","journal-title":"Int J Colorectal Dis"},{"key":"4926_CR27","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1007\/s00384-014-1971-2","volume":"29","author":"A Perrakis","year":"2014","unstructured":"Perrakis A, Weber K, Merkel S et al (2014) Lymph node metastasis of carcinomas of transverse colon including flexures. Consideration of the extramesocolic lymph node stations. Int J Colorectal Dis 29:1223\u20131229. https:\/\/doi.org\/10.1007\/s00384-014-1971-2","journal-title":"Int J Colorectal Dis"},{"key":"4926_CR28","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1097\/SLE.0000000000000419","volume":"27","author":"A Mart\u00ednez-P\u00e9rez","year":"2017","unstructured":"Mart\u00ednez-P\u00e9rez A, Brunetti F, Vitali GC, Abdalla S, Ris F, de\u2019Angelis N, (2017) Surgical Treatment of Colon Cancer of the Splenic Flexure: A Systematic Review and Meta-analysis. Surg Laparosc Endosc Percutan Tech 27:318\u2013327. https:\/\/doi.org\/10.1097\/SLE.0000000000000419","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"key":"4926_CR29","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1177\/000313481708300620","volume":"83","author":"A Rencuzogullari","year":"2017","unstructured":"Rencuzogullari A, Benlice C, Costedio M, Remzi FH, Gorgun E (2017) Nomogram-derived prediction of postoperative ileus after colectomy: An assessment from nationwide procedure-targeted cohort. Am Surg 83:564\u2013572. https:\/\/doi.org\/10.1177\/000313481708300620","journal-title":"Am Surg"},{"key":"4926_CR30","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1152\/ajpgi.00021.2017","volume":"312","author":"AY Lin","year":"2017","unstructured":"Lin AY, Du P, Dinning PG et al (2017) High-resolution anatomic correlation of cyclic motor patterns in the human colon: Evidence of a rectosigmoid brake. Am J Physiol Gastrointest Liver Physiol 312:508\u2013515. https:\/\/doi.org\/10.1152\/ajpgi.00021.2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"4926_CR31","doi-asserted-by":"publisher","unstructured":"Seo SHB, Bissett I, O\u2019Grady G (2021) Variable gut function recovery after right vs. left colectomy may be due to rectosigmoid hyperactivity. Front Physiol 12: 635167. https:\/\/doi.org\/10.3389\/fphys.2021.635167.","DOI":"10.3389\/fphys.2021.635167"},{"key":"4926_CR32","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s00383-010-2841-9","volume":"27","author":"S Folaranmi","year":"2011","unstructured":"Folaranmi S, Rakoczy G, Bruce J et al (2011) Ileocaecal valve: how important is it? Pediatr Surg Int 27:613\u2013615. https:\/\/doi.org\/10.1007\/s00383-010-2841-9","journal-title":"Pediatr Surg Int"},{"key":"4926_CR33","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1007\/s00384-017-2840-6","volume":"32","author":"N Iba\u00f1ez","year":"2017","unstructured":"Iba\u00f1ez N, Abrisqueta J, Luj\u00e1n J, Hern\u00e1ndez Q, Parrilla P (2017) Isoperistaltic versus antiperistaltic side-to-side anastomosis after right laparoscopic hemicolectomy for cancer (ISOVANTI) trial: study protocol for a randomised clinical trial. Int J Colorectal Dis 32:1349\u20131356. https:\/\/doi.org\/10.1007\/s00384-017-2840-6","journal-title":"Int J Colorectal Dis"},{"key":"4926_CR34","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1136\/gut.2008.169250","volume":"58","author":"GE Boeckxstaens","year":"2009","unstructured":"Boeckxstaens GE, de Jonge WJ (2009) Neuroimmune mechanisms in postoperative ileus Gut 58:1300\u20131311. https:\/\/doi.org\/10.1136\/gut.2008.169250","journal-title":"Neuroimmune mechanisms in postoperative ileus Gut"},{"key":"4926_CR35","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1111\/codi.13949","volume":"20","author":"Yorkshire Surgical Research Collaborative","year":"2018","unstructured":"Yorkshire Surgical Research Collaborative (2018) Multicentre observational study of gastrointestinal recovery after elective colorectal surgery. Colorectal Dis 20:536\u2013544. https:\/\/doi.org\/10.1111\/codi.13949","journal-title":"Colorectal Dis"},{"key":"4926_CR36","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1007\/s00464-020-08252-6","volume":"36","author":"M Zhang","year":"2022","unstructured":"Zhang M, Lu Z, Zheng Z, Cheng P, Zhou H, Wang X (2022) Comparison of short-term outcomes between totally laparoscopic right colectomy and laparoscopic-assisted right colectomy: a retrospective study in a single institution on 300 consecutive patients. Surg Endosc 36:176\u2013184. https:\/\/doi.org\/10.1007\/s00464-020-08252-6","journal-title":"Surg Endosc"}],"container-title":["International Journal of Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-025-04926-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00384-025-04926-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00384-025-04926-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T20:36:53Z","timestamp":1748983013000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00384-025-04926-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4926"],"URL":"https:\/\/doi.org\/10.1007\/s00384-025-04926-6","relation":{},"ISSN":["1432-1262"],"issn-type":[{"value":"1432-1262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,3]]},"assertion":[{"value":"27 May 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"134"}}