{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T16:40:10Z","timestamp":1749141610493,"version":"3.41.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum W\u00fcrzburg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Rates of surgery remain relevant for localized Crohn\u2019s disease despite the evolution of novel therapies. However, the effect of immunosuppressive medication on the perioperative outcome including the extent of the resection is still inconclusive and needs to be evaluated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>In a single-center study, all patients who received ileocolic resection due to localized Crohn\u2019s disease were retrospectively assessed and divided into two groups depending on previous treatment (preoperative medication versus therapy-na\u00efve). Outcome parameters included patient characteristics, surgical and histopathological aspects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Two hundred thirty-seven patients were analyzed of whom 192 patients received medical treatment prior to surgery. Preoperative treatment had neither an effect on the length of the resected specimen (29.4\u00a0cm versus 27.1\u00a0cm, <jats:italic>p<\/jats:italic>\u2009=\u20090.27) nor on the postoperative outcome. Only rates of conversion were significantly increased for therapy-na\u00efve patients compared to patients receiving preoperative treatment (15.6% versus 5.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.025).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Preoperative medical treatment does not have an effect on the extent of the resected bowel segment in patients suffering from localized Crohn\u2019s disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00384-025-04927-5","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T04:24:13Z","timestamp":1749097453000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative immunosuppressive therapy might not affect the length of resected bowel in patients receiving ileocolic resection for Crohn\u2019s disease"],"prefix":"10.1007","volume":"40","author":[{"given":"Matthias","family":"Kelm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Bredl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Widder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Schoettker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Brand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Meining","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Pistorius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Reibetanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Schlegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph-Thomas","family":"Germer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Flemming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"issue":"10114","key":"4927_CR1","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","volume":"390","author":"SC Ng","year":"2017","unstructured":"Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI et al (2017) Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. 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