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This network meta-analysis evaluates the combination of different pill numbers of Lin with polyethylene glycol (PEG) (high and low volumes in liters (L)) for bowel cleansing.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This systematic review and frequentist network meta-analysis, conducted in October 2024, assessed randomized controlled trials (RCTs) from Scopus, PubMed, Cochrane, WOS, and Embase. Risk ratios (RR) and mean differences (MD) with 95% confidence intervals (CI) were calculated for categorical and continuous outcomes. PROSPERO ID: CRD42024618272.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Fourteen RCTs with 4,764 participants showed that total Boston\u00a0Bowel\u00a0Preparation\u00a0Scale improved significantly with 2L PEG\u2009+\u20092Lin (MD\u2009=\u20092.03, 95%CI: [0.30:3.76], <jats:italic>P<\/jats:italic>\u2009=\u20090.0217), 3L-PEG\u2009+\u20093Lin (MD\u2009=\u20091.30, 95%CI: [0.42:2.18], <jats:italic>P<\/jats:italic>\u2009=\u20090.0038), and 4L-PEG (MD\u2009=\u20091.11, 95%CI: 0.23\u20131.98, <jats:italic>P<\/jats:italic>\u2009=\u20090.0129). Adenoma detection was highest with 3L-PEG\u2009+\u20093Lin (RR\u2009=\u20091.60, 95%CI: [1.05:2.43], <jats:italic>P<\/jats:italic>\u2009=\u20090.0280), while polyp detection improved with 2L PEG\u2009+\u20093Lin (RR\u2009=\u20091.72, 95%CI: [1.13:2.62], <jats:italic>P<\/jats:italic>\u2009=\u20090.0114) and 3L-PEG\u2009+\u20093Lin (RR\u2009=\u20091.33, 95%CI: [1.00:1.77], <jats:italic>P<\/jats:italic>\u2009=\u20090.0505). Procedure times were significantly reduced with 3L-PEG\u2009+\u20093Lin (MD\u2009=\u2009-4.6, 95%CI: [-6.24:-3.24], <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), 3L-PEG\u2009+\u20091Lin (<jats:italic>P<\/jats:italic>\u2009=\u20090.035), and 4L-PEG (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Abdominal pain and abdominal bloating decreased with 2L PEG\u2009+\u20091Lin (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and 2L PEG\u2009+\u20092Lin (<jats:italic>P<\/jats:italic>\u2009=\u20090.021) but increased with 4L-PEG (<jats:italic>P<\/jats:italic>\u2009=\u20090.0178).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Combining PEG with Lin improves bowel cleanliness compared to 3L-PEG, with 2L PEG\u2009+\u20092Lin being the most effective and well-tolerated. Despite some heterogeneity, the findings suggest that adding Lin may enhance bowel preparation with\u00a0comparable safety, warranting consideration of individual patient factors.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00384-025-04931-9","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T22:56:05Z","timestamp":1750200965000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Combined linaclotide and polyethylene glycol electrolyte for colonoscopy preparation: a network meta-analysis of 14 randomized controlled trials"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3080-2875","authenticated-orcid":false,"given":"Mohamed S.","family":"Elgendy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6539-0417","authenticated-orcid":false,"given":"Islam","family":"Rajab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0460-507X","authenticated-orcid":false,"given":"Qasi","family":"Najah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0767-1070","authenticated-orcid":false,"given":"Mohamed A.","family":"Faheem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5028-904X","authenticated-orcid":false,"given":"Omar K.","family":"Elsawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9192-4175","authenticated-orcid":false,"given":"Hosam I.","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8144-9962","authenticated-orcid":false,"given":"Mariam","family":"Elewidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8300-0262","authenticated-orcid":false,"given":"Abdalhakim","family":"Shubietah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruv","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8266-5003","authenticated-orcid":false,"given":"Alisa","family":"Farokhian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2514-0689","authenticated-orcid":false,"given":"Mohamed","family":"Abuelazm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Baddoura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"4931_CR1","doi-asserted-by":"crossref","unstructured":"Siegel RL, Wagle NS, Cercek A, Smith RA, Jemal A (2023) Colorectal cancer statistics. 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