{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:18:39Z","timestamp":1789600719916,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of intestinal mesentery and the extent of its resection as a determinant of outcomes post-bowel resection in Crohn\u2019s disease (CD) remains a subject of debate. We evaluated outcomes of conventional mesenteric resection (CMR) and compared it with extended mesenteric resection (EMR) in patients undergoing ileo-colic excision for limited ileo-colonic CD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search was conducted in accordance with PRISMA guidelines using Medline, Embase, PubMed, and Cochrane databases. Comparative studies of patients with limited ileo-colonic CD undergoing CMR and EMR for ileo-colic resection were included. Studies comparing anastomotic techniques, single-arm, case reports\/series, study protocols and editorials were excluded. Primary outcomes were disease recurrence and re-operation. Secondary outcomes included post-operative complications, intra-operative blood loss, length of stay, total operative time and re-admission rate. Meta-analysis was performed using Cochrane RevMan Web on outcomes reported by two or more studies. Combined overall effect sizes were calculated using random-effects model and the Newcastle\u2013Ottawa Scale and Cochrane risk-of-bias tools were used to assess bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five studies met our inclusion criteria (four retrospective cohort studies; one randomised controlled trial (RCT)) with a total of 4,358 patients (EMR: 993 vs. CMR: 3,365). No statistical difference was observed across any of the analysed outcomes: disease recurrence [OR: 0.49 CI 0.21\u20141.16, P\u2009=\u20090.10], re-operation [OR: 0.33 CI 0.06\u20141.65, P\u2009=\u20090.17], intra-operative blood loss [MD: -18.71 CI -76.65\u201439.23, P\u2009=\u20090.53], anastomotic leak [OR: 0.98 CI 0.34\u20142.82, P\u2009=\u20090.97], length of stay [MD: -0.06 CI -0.59\u20140.48, P\u2009=\u20090.83], post-operative morbidity [OR: 1.01 CI 0.82\u20141.24, P\u2009=\u20090.95], blood transfusion [OR: 1.16 CI 0.84\u20141.59, P\u2009=\u20090.36], Clavien-Dindo III\u2009+\u2009complications [OR: 0.83 CI 0.5\u20141.38, P\u2009=\u20090.47], post-operative ileus [OR: 0.97 CI 0.27\u20143.50, P\u2009=\u20090.96], intra-abdominal bleeding [OR: 0.85 CI 0.22\u20143.26, P\u2009=\u20090.81], re-admission [OR: 0.65 CI 0.24\u20141.78, P\u2009=\u20090.40], surgical site infection [OR: 1.00 CI 0.77\u20141.30, P\u2009=\u20090.99], post-operative adjuvant or prophylactic therapy [OR: 0.90 CI 0.54\u20141.51, P\u2009=\u20090.69] and total operative time [MD: 0.38 CI -4.42\u20145.19, P\u2009=\u20090.88].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Performing EMR during ileo-colic resection for patients with limited ileo-colonic CD does not seem to confer any additional benefit to conventional (limited resection) approaches. Robust, well-designed, large-scale RCTs are needed to better compare these techniques and demonstrate superiority in clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00384-025-04937-3","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T22:59:30Z","timestamp":1750201170000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical outcomes of conventional versus extended mesenteric resection in limited ileo-colonic Crohn\u2019s disease: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"40","author":[{"given":"Omar E. 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This work has not been published previously and the manuscript (including related data) is not under consideration elsewhere.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Assistance with the study"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"144"}}