{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T14:01:11Z","timestamp":1784642471607,"version":"3.55.0"},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Colorectal carcinoma (CC) is a rare disease in the pediatric population, with an annual incidence of 1 in 10 million adolescents, and it accounts for approximately 1% of pediatric solid neoplasms. It is the most common primary gastrointestinal malignancy in children with the vast majority of CCs being adenocarcinoma (CA). Unfortunately, the proportion of poorly differentiated, mucinous type, signet-ring cell containing carcinomas is higher in younger patients than in adults. Moreover, due to the low awareness of the disease, diagnosis is usually delayed until advanced stages, resulting in an extremely poor prognosis. Surgery is the only curative modality for localized CAs, whereas adjuvant chemotherapy is the standard of care for patients with stage III cancer to eradicate micro-metastases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>In the last 10 years, we treated 3 patients diagnosed with CA: a 14-year-old female, a 15-year-old male, and a 15-year-old female. All patients presented to our Emergency Department with nonspecific symptoms of abdominal pain and vomiting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All patients were subjected to laparoscopic tumor resection to relief intestinal obstruction. In the male patient, laparoscopy was converted to laparotomy to safely assess the anatomy because of strong peritoneal adhesions. No stomas were created, in order to improve quality of life. Oxaliplatin and 5-fluorouracil-based regimens were among the most commonly used chemotherapy combinations. The 15-year-old female and the 15-year-old male died 1 year after the surgical resection, while the 14-year-old female is still on follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CAs behave aggressively in children; they not only show a poorer response to chemotherapy, but are also associated with extensive intramural spread and peritoneal carcinomatosis. Lack of awareness and timely intervention remain the main challenges for early diagnosis and improved prognosis of CA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00384-025-05017-2","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T05:35:30Z","timestamp":1763530530000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Colorectal adenocarcinoma in children and adolescents: the management of advanced disease"],"prefix":"10.1007","volume":"40","author":[{"given":"Riccardo","family":"Guan\u00e0","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Sofia","family":"Soto Torselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"De Leo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Perin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Morgani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Ettore","family":"Allaix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Piglione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Di Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico Costantino","family":"Falco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Gennari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"issue":"1","key":"5017_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jamcollsurg.2019.03.022","volume":"229","author":"VN Nfonsam","year":"2019","unstructured":"Nfonsam VN, Jecius H, Chen D, Omesiete PN, Ewongwo AN, Elquza E, Scott AJ, Jandova J (2019) Increasing incidence of colon cancer in the young: assessing the tumor biology. 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S2255\u2013534X(24)00077-X."},{"issue":"1","key":"5017_CR4","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/jpn3.12257","volume":"79","author":"S Cohen","year":"2024","unstructured":"Cohen S, Yerushalmy-Feler A, Rojas I, Phen C, Rudnick DA, Flahive CB, Erdman SH, Magen-Rimon R, Copova I, Attard T, Latchford A, Hyer W (2024) Juvenile polyposis syndrome in children: the impact of SMAD4 and BMPR1A mutations on clinical phenotype and polyp burden. J Pediatr Gastroenterol Nutr 79(1):161\u2013167","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"7","key":"5017_CR5","first-page":"798","volume":"29","author":"B Erginel","year":"2023","unstructured":"Erginel B, Mustafayeva N, Karada\u011f \u00c7A, Yanar F, Kebudi R, Tanyildiz HG, Tugcu D, Berker N, Ilhan B, G\u00fcn Soysal F (2023) A rare cause of intestinal obstruction in children: signet-ring cell adenocarcinoma of the colon. Ulus Travma Acil Cerrahi Derg 29(7):798\u2013805","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"key":"5017_CR6","doi-asserted-by":"publisher","DOI":"10.1200\/PO.22.00378","volume":"7","author":"N Qureshi","year":"2023","unstructured":"Qureshi N, Hoffman TL, Kaneva K, Zomorrodian S, Scapa JV, Hitchins MP, Federman N (2023) Pediatric rectal adenocarcinoma with mismatch repair deficiency responds to immunotherapy. JCO Precis Oncol 7:e2200378","journal-title":"JCO Precis Oncol"},{"issue":"20","key":"5017_CR7","doi-asserted-by":"publisher","first-page":"4566","DOI":"10.1158\/1078-0432.CCR-24-0953","volume":"30","author":"SP MacFarland","year":"2024","unstructured":"MacFarland SP, Becktell K, Schneider KW, Kuiper RP, Lesmana H, Meade J, Nichols KE, Porter CC, Savage SA, Schultz KA, Scott H, States L, Tabori U, Tamura C, Tomlinson G, Zelley K, Durno C, Bauer A, Plon SE (2024Oct 15) Pediatric cancer screening in hereditary gastrointestinal cancer risk syndromes: an update from the AACR Childhood Cancer Predisposition Working Group. 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