{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:32:47Z","timestamp":1789435967279,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"This study was funded by ALF and Regional grants."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>High-risk colon cancer may benefit from preoperative chemotherapy (preCHT), but evidence on its short-term safety and outcome is limited. Population-based evidence before its incorporation into national guidelines is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with final weighted stage II\u2013III colon cancer undergoing elective resection between 2007 and 2017 were identified in the Swedish Colorectal Cancer Registry. Patients planned for preCHT, irrespective of intention, were compared with those undergoing upfront surgery. Primary outcomes were 30- and 90-day mortality and 30-day major morbidity, defined as all medical and surgical complications classified as Clavien-Dindo (CD)\u2009\u2265\u20093 grade. Subgroup analyses examined cT4 disease, and multivariable logistic regression was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 20,185 eligible patients, 299 (1.5%) received preCHT. Postoperative mortality was comparable (1.7% vs. 1.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.00 at 30 days and 3.0% vs. 2.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.82 at 90 days). Overall and surgical postoperative morbidity (CD\u2009\u2265\u20093) was higher in the preCHT group (34.1 vs. 25.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and 17.4% vs. 13.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), rates of anastomotic leakage were similar (3.3% vs. 3.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.85). Compared to upfront surgery, the preCHT group was more likely to undergo multivisceral resections (53.9% vs. 13.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with a higher rate of R1 resections (6.4% vs. 3.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), reflecting more advanced disease (cT4: 59.5% vs. 10.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; cN1-2: 54.9% vs. 28.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the cT4 subgroup, short-term outcomes were comparable, and regression analyses found no independent association between preCHT and mortality or major morbidity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PreCHT appeared feasible in cT4N0-2M0 colon cancer, with short-term outcomes comparable to upfront surgery despite more advanced primary tumour and greater surgical extent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00384-025-05060-z","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:17:45Z","timestamp":1767971865000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preoperative chemotherapy for colon cancer and short-term outcomes\u2014a nationwide cohort study"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7761-2492","authenticated-orcid":false,"given":"M.","family":"Delorme","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4463-2336","authenticated-orcid":false,"given":"E.","family":"Agger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3876-4033","authenticated-orcid":false,"given":"F.","family":"J\u00f6rgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4803-8548","authenticated-orcid":false,"given":"M. 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