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This study aimed to examine whether high-frequency follow-up after CRC surgery reduces 5-year overall mortality, cancer-specific mortality and recurrence in patients with CRC aged\u2009\u2264\u200950\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The COLOFOL trial performed between 2006 and 2010 was used to analyse patients randomised to high-frequency (computed tomography [CT]\u00a0of the abdomen and thorax and a carcinoembryonic antigen [CEA] test at 6, 12, 18, 24 and 36\u00a0months) versus low-frequency (CT and CEA at 12 and 36\u00a0months) follow-up after curative CRC surgery. Intention-to-treat and per-protocol analyses were performed to study the primary outcomes (5-year overall mortality and cancer-specific mortality) and the secondary outcome (CRC recurrence), comparing the age groups\u2009\u2264\u200950, 51\u201370 and\u2009&gt;\u200970\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 2,509 patients were included in the intention-to-treat analysis with 183, 1,714 and 612 patients aged\u2009\u2264\u200950, 51\u201370 and\u2009&gt;\u200970\u00a0years, respectively. The 5-year overall mortality risk for patients aged\u2009\u2264\u200950 was 8.3% in the high-frequency group compared with 8.4% in the low-frequency group (risk difference 0.2% [95% CI,\u2009\u2212\u20098.0; 8.3]). The cancer-specific mortality risk for patients aged\u2009\u2264\u200950\u00a0years was 7.1% in the high-frequency group compared with 7.4% in the low-frequency group (risk difference, 0.3% [95% CI,\u2009\u2212\u20097.4; 8.0]). The cancer-specific recurrence risk for patients aged\u2009\u2264\u200950\u00a0years was 12.9% in the high-frequency group compared with 21.0% in the low-frequency group (risk difference 8.1% [95% CI,\u2009\u2212\u20092.6; 18.7]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among individuals aged\u2009\u2264\u200950\u00a0years with stage II-III CRC, there was no reduction in overall mortality, cancer-specific mortality and cancer-specific recurrence with more intensive follow-up using CT and CEA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00384-026-05096-9","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T11:55:39Z","timestamp":1769428539000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Follow-up intensity after colorectal cancer 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