{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:21:12Z","timestamp":1786980072425,"version":"build-2736575974"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Medizinische Fakult\u00e4t Mannheim der Universit\u00e4t Heidelberg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Colorectal Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This long-term follow-up study evaluates clinical and functional outcomes after ileocecal resection with either Kono-S or conventional anastomosis techniques in patients with Crohn\u2019s disease. The goal was to determine whether the Kono-S approach confers a long-term advantage in preventing disease recurrence and improving quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary of background data<\/jats:title>\n                    <jats:p>While the Kono-S anastomosis has shown promise in reducing recurrence rates in Crohn\u2019s disease following surgery, most existing evidence stems from short- to medium-term follow-up. High-quality long-term data remain scarce, particularly in real-world clinical settings. This study aims to fill that gap.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective-prospective cohort analysis was performed including patients who underwent ileocecal resection for Crohn\u2019s disease between 2015 and 2017 at a single academic center. Patients were grouped according to anastomosis technique (Kono-S vs. conventional). Long-term follow-up data were obtained via chart review, imaging studies, and patient-reported questionnaires, including the Gastrointestinal Quality of Life Index (GIQLI). Primary outcomes included recurrence rates, postoperative complications, and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy patients were included in the final analysis (Kono-S:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931; conventional:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200939). The median follow-up duration was 8.1\u00a0years (interquartile range = 6.9\u20138.8\u00a0years). No significant differences were observed between groups regarding endoscopic inflammation (Kono-S = 19.4%, conventional = 25.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.39), restenosis (Kono-S = 9.7%, conventional = 2.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.34), or GIQLI scores (Kono-S: median 116 vs. 110,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08). Rehospitalization rates were numerically higher in the Kono-S group (16.1% vs. 2.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.0), but not statistically significant. Importantly, approximately 40% of all patients retrospectively stated they would have preferred earlier surgical intervention, independent of the anastomotic technique.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>After more than 7 years of follow-up, the Kono-S anastomosis demonstrates comparable long-term outcomes to conventional techniques in terms of recurrence, complications, and quality of life. Patient reflections suggest a potential benefit of earlier surgical intervention, highlighting the need for more proactive surgical referral in gastroenterological practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00384-026-05098-7","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T21:14:32Z","timestamp":1770066872000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long-term outcomes of Kono-S anastomosis for ileocecal resections in Crohn\u2019s disease: a comparative analysis"],"prefix":"10.1007","volume":"41","author":[{"given":"Maximilian","family":"Vojta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kienle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Rei\u00dffelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Wei\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Seyfried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"5098_CR1","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1046\/j.1365-2168.2000.01589.x","volume":"87","author":"O Bernell","year":"2000","unstructured":"Bernell O, Lapidus A, Hellers G (2000) Risk factors for surgery and recurrence in 907 patients with primary ileocaecal Crohn\u2019s disease. 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J Gastrointest Surg 23:312\u2013319","journal-title":"J Gastrointest Surg"},{"key":"5098_CR10","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad214","author":"G Tyrode","year":"2023","unstructured":"Tyrode G, Lakkis Z, Vernerey D et al (2023) KONO-S anastomosis is not superior to conventional anastomosis for the reduction of postoperative endoscopic recurrence in Crohn\u2019s disease. Inflamm Bowel Dis. https:\/\/doi.org\/10.1093\/ibd\/izad214","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"5098_CR11","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1093\/ecco-jcc\/jjad176","volume":"18","author":"L Alibert","year":"2024","unstructured":"Alibert L, Betton L, Falcoz A et al (2024) Does kono-s anastomosis reduce recurrence in crohn\u2019s disease compared with conventional ileocolonic anastomosis? A nationwide propensity score-matched study from getaid chirurgie group [KoCoRICCO Study]. 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