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MSI-H and MMRd play key roles in CRC, but data on their prevalence in Hispanic\/Latino populations are limited. This study evaluates these biomarkers in the region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta-analysis were conducted following PRISMA guidelinesin Medline, Virtual Health Library, Scopus, and Web of Science. Random-effects models were used to estimate pooled prevalence due to expected heterogeneity between studies. Studies (cohort and cross-sectional) that evaluated MMRd and\/or MSI-H through IHC and PCR techniques in Hispanic\/Latino individuals with colorectal cancer (whether sporadic, associated with Lynch Syndrome, or other forms), residing in Latin American countries or elsewhere, were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 52 studies including 10,596 patients were included. The pooled prevalence of mismatch repair deficiency (MMRd) and microsatellite instability-high (MSI-H) in Hispanic\/Latino populations was 15% (95% CI: 10%\u201320%; I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200989.6%) and 18% (95% CI: 13%\u201324%; I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200984.0%), respectively. Costa Rica and Mexico had the highest MMRd prevalence (30% and 24%), while Uruguay showed the highest MSI-H prevalence (45%). MSI-H was significantly associated with female sex (OR: 1.83) and right-sided tumors (OR: 8.16). MMRd was associated with right-sided tumors compared with the rectum (OR: 1.73) and the left colon (OR: 5.65).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta-analysis underscores the unique prevalence of MMRd and MSI-H in Hispanics, highlighting regional variations and the need for broader representation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00384-026-05146-2","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:57:59Z","timestamp":1779357479000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microsatellite instability and mismatch repair deficiency prevalence among Hispanic\/Latino individuals with colorectal cancer: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"41","author":[{"given":"Gabriela","family":"Guerron-Gomez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F.","family":"Mendivelso-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Chaves-Cabezas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Chaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n C.","family":"Ria\u00f1o-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Parra-Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"issue":"3","key":"5146_CR1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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