{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:26:27Z","timestamp":1792409187208,"version":"4.4.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008349","name":"Universit\u00e4t Duisburg-Essen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008349","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Z Gerontol Geriat"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Hintergrund<\/jats:title>\n                    <jats:p>Menschen mit einem Down-Syndrom (MmDS) haben ein genetisch bedingt stark erh\u00f6htes Risiko, an einer fr\u00fch beginnenden Alzheimer-Demenz zu erkranken. In einer Interviewstudie mit \u00c4rzt:innen, Patientenvertretungen sowie Mitarbeitenden in Wohn- und Arbeitseinrichtungen wurden Defizite im medizinischen Versorgungsprozess und L\u00f6sungsans\u00e4tze erhoben.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodik<\/jats:title>\n                    <jats:p>Es wurden 14 teilstrukturierte Interviews durchgef\u00fchrt und \u00fcber eine qualitative Inhaltsanalyse ausgewertet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ergebnisse<\/jats:title>\n                    <jats:p>Fehlende Kenntnisse und Erfahrungen von \u00c4rzt:innen im Umgang mit sowie in der medizinischen Versorgung von MmDS zeigten sich als zentrale Herausforderung. Zudem ist die Diagnostik der Demenz bei MmDS aufgrund verschiedener Ursachen (u.\u202fa. Fehlen geeigneter Diagnostikinstrumente in der Regelversorgung, fehlende zeitliche\/finanzielle Ressourcen) erschwert. Zweifel an der Wirksamkeit von Antidementiva wurden ge\u00e4u\u00dfert sowie Hintergr\u00fcnde f\u00fcr einen erh\u00f6hten Einsatz sedierender Medikamente diskutiert.<\/jats:p>\n                    <jats:p>Eine aufmerksame Verhaltensbeobachtung und eine Einbindung von Betreuenden, eine regelm\u00e4\u00dfige \u00dcberpr\u00fcfung und Reduktion von Multimedikation sowie der Einsatz alternativer Verhaltensmodifikationstechniken wurden als L\u00f6sungsans\u00e4tze genannt.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Schlussfolgerung<\/jats:title>\n                    <jats:p>Die identifizierten Defizite in der medizinischen Versorgung der Zielpopulation sowie die L\u00f6sungsans\u00e4tze gehen in die Entwicklung gesundheitspolitischer Handlungsempfehlungen ein, um die Versorgungssituation nachhaltig zu optimieren.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00391-024-02371-8","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T17:01:37Z","timestamp":1728493297000},"page":"397-404","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Alzheimer-Demenz bei Menschen mit einem Down-Syndrom","Alzheimer\u02bcs dementia in people with Down syndrome"],"prefix":"10.1007","volume":"58","author":[{"given":"Theresa","family":"H\u00fcer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Weitzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godwin Denk","family":"Giebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Raszke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Wasem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"N\u00fcbling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Wagemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Wlasich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Pantel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Tesky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Schall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Walendzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"issue":"9","key":"2371_CR1","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nrn3983","volume":"16","author":"FK Wiseman","year":"2015","unstructured":"Wiseman\u00a0FK, Al-Janabi\u00a0T, Hardy\u00a0J et\u00a0al (2015) A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome. 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F\u00fcr die aufgef\u00fchrten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Interessenkonflikt"}}]}}