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Anstalt \u00f6ffentlichen Rechts"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Z Gerontol Geriat"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Polypharmacy is a\u00a0widespread phenomenon in older patients. In particular, the anticholinergic burden of medication is an important risk factor for delirium due to age-related changes in the cholinergic system.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Preoperative medication, including the calculation of the anticholinergic burden (ACB), was recorded in a\u00a0prospective study (421 patients) to identify potential risks associated with medication intake. Postoperative delirium screening was carried out daily.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The study included 199 women (47.3%) and 222 men (52.7%) aged 80.8\u202f\u00b1\u20096.7 years and 78.8\u202f\u00b1\u20096.2\u00a0years, respectively. Antidepressants odds ratio (OR) 3.16 (95% confidence interval. CI, 1.51\u20136.64), antidiabetic drugs OR 2.53 (95% CI 1.27\u20135.03), neuroleptics OR 3.52 (95% CI 1.70\u20137.28) and Parkinson medication OR 5.88 (95% CI 1.95\u201317.7) showed a\u00a0significantly higher risk for delirium. The ACB score revealed an anticholinergic burden in 43\u00a0patients (10.4%). The delirium rate was 25.6% (<jats:italic>n<\/jats:italic>\u202f=\u200911) and 11.0% (<jats:italic>n<\/jats:italic>\u202f=\u200940) had no anticholinergic burden. A\u00a0significant correlation can be demonstrated with \u03c7<jats:sup>2<\/jats:sup>(1)\u202f=\u202f7.52, <jats:italic>p<\/jats:italic>\u202f=\u20090.006, Cramer\u2019s V\u202f=\u20090.136. There was a\u00a02.79-fold higher risk of delirium (OR 2.79, 95% CI 1.31\u20135.97).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The standardized recording of medication is essential, especially when identifying patients at risk of suffering from delirium. The use of the ACB score to assess the anticholinergic burden is a\u00a0simple and reliable screening tool and should be part of a\u00a0preoperative geriatric assessment.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00391-024-02388-z","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T15:26:37Z","timestamp":1736177197000},"page":"203-208","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Polypharmacy and anticholinergic burden as risk factors for postoperative delirium in surgical medicine","Polypharmazie und anticholinerge Belastung als Risikofaktoren f\u00fcr postoperatives Delir in der Chirurgie"],"prefix":"10.1007","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1040-8814","authenticated-orcid":false,"given":"Henriette Louise","family":"Moellmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soufian","family":"Boulghoudan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Kuhlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa","family":"Rahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Frohnhofen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"2388_CR1","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/S0140-6736(13)60688-1.","volume":"383","author":"SK Inouye","year":"2014","unstructured":"Inouye\u00a0SK, Westendorp\u00a0RGJ, Saczynski\u00a0JS (2014) Delirium in elderly people. 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