{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:28:38Z","timestamp":1761560918963},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Kardiol"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1007\/s00392-004-0122-0","type":"journal-article","created":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T13:23:46Z","timestamp":1097587426000},"page":"784-790","source":"Crossref","is-referenced-by-count":8,"title":["The brugada syndrome"],"prefix":"10.1007","volume":"93","author":[{"given":"N.","family":"Sreeram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Simmers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Brockmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"CR1","first-page":"80","volume":"22","author":"Aihara","year":"1990","unstructured":"Aihara N, Ohe T, Kamakura S (1990) Clinical and electrophysiologic characteristics of idiopathic ventricular fibrillation. Shinzo 22:80?86","journal-title":"Shinzo"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1046\/j.1460-9592.2001.01420.x","volume":"24","author":"Alings","year":"2001","unstructured":"Alings M, Dekker L, Sadee et al (2001) Quinidine induced electrocardiographic normalization in two patients with Brugada syndrome. PACE 24:1420?1422","journal-title":"PACE"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/S0735-1097(03)00310-3","volume":"41","author":"Anzelevitch","year":"2003","unstructured":"Anzelevitch C, Brugada P, Brugada J et al (2003) Brugada syndrome: 1992?2002. A historical perspective. Am Coll Cardiol 41:1665?1671","journal-title":"Am Coll Cardiol"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1046\/j.1460-9592.2002.01537.x","volume":"25","author":"Anzelevitch","year":"2002","unstructured":"Anzelevitch C, Brugada R (2002) Fever and Brugada syndrome: PACE 25:1537?1539","journal-title":"PACE"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1046\/j.1460-9592.2002.01634.x","volume":"25","author":"Belhassen","year":"2002","unstructured":"Belhassen B, Viskin 2, Anzelevitch C (2002) The Brugada syndrome: is ICD the only therapeutic option? PACE 25:1634?1640","journal-title":"PACE"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/j.1540-8167.1999.tb00183.x","volume":"10","author":"Belhassen","year":"1999","unstructured":"Belhassen B, Viskin S, Fish R et al (1999) Effects of electrophysiologic-guided therapy with class 1A antiarrhythmic drugs on the long-term outcome of patients with idiopathic ventricular fibrillation with or without the Brugada syndrome. J Cardiovasc Electrophysiol 10:1301?1312","journal-title":"J Cardiovasc Electrophysiol"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/01.RES.85.12.1206","volume":"85","author":"Bezzina","year":"1999","unstructured":"Bezzina C, Veldkamp MW, van den Berg MP et al (1999) A single Na+ channel mutation causing both long-QT and Brugada syndromes. Circ Res 85:1206?1213","journal-title":"Circ Res"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0008-6363(00)00272-8","volume":"49","author":"Bezzina","year":"2001","unstructured":"Bezzina CR, Rook MB, Wilde AAM (2001) Cardiac sodium channel and inherited arrhythmia syndrome. Cardiovasc Res 49:257?271","journal-title":"Cardiovasc Res"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1540-8167.1998.tb00875.x","volume":"9","author":"Bjerregaard","year":"1998","unstructured":"Bjerregaard P, Gussak I, Antzelevitch C (1998) The enigmatic ECG manifestation of Brugada syndrome. J Cardiovasc Electrophysiol 9:109?111","journal-title":"J Cardiovasc Electrophysiol"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s003920050310","volume":"88","author":"Breuer","year":"1999","unstructured":"Breuer HWM, Breithardt G, Borggrefe M (1999) Das Brugada-Brugada-Syndrom. Eine (un)typische Kasuistik. Z Kardiol 88:467?472","journal-title":"Z Kardiol"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1161\/hc0102.101354","volume":"105","author":"Brugada","year":"2002","unstructured":"Brugada J, Brugada R, Antzelevitch C et al (2002) Long-term follow-up of individuals with the electrocardiographic pattern of right bundlebranch block and ST-segment elevation in precordial leads V1 to V3. Circulation 105:73?78","journal-title":"Circulation"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1054\/jelc.2000.20322","volume":"33","author":"Brugada","year":"2000","unstructured":"Brugada J, Brugada R, Brugada P (2000) Pharmacological and device approach to therapy of inherited cardiac diseases associated with cardiac arrhythmias and sudden death. J Electrocardiol 33(Suppl):41?47","journal-title":"J Electrocardiol"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1046\/j.1540-8167.2003.02517.x","volume":"14","author":"Brugada","year":"2003","unstructured":"Brugada P, Brugada R, Mont L et al (2003) Natural history of Brugada syndrome: the prognostic value of programmed extrastimulation of the heart. J Cardiovasc Electrophysiol 14:455?457","journal-title":"J Cardiovasc Electrophysiol"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1046\/j.1540-8167.2003.02517.x","volume":"14","author":"Brugada","year":"2003","unstructured":"Brugada P, Brugada R, Mont L, Rivero M, Geelen P, Brugada J (2003) Natural history of Brugada syndrome: the prognostic value of programmed electrical stimulation of the heart. J Cardiovasc Electrophysiol 14:455?457","journal-title":"J Cardiovasc Electrophysiol"},{"key":"CR15","first-page":"746","volume":"14","author":"Brugada","year":"1991","unstructured":"Brugada P, Brugada J (1991) A distinct clinical and electrocardiographic syndrome: right bundlebranch block, persistent ST segment elevation with normal QT interval and sudden cardiac death. PACE 14:746","journal-title":"PACE"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0735-1097(92)90253-J","volume":"20","author":"Brugada","year":"1992","unstructured":"Brugada P, Brugada J (1992) Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. J Am Coll Cardiol 20:1391?1396","journal-title":"J Am Coll Cardiol"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1161\/01.CIR.101.5.510","volume":"101","author":"Brugada","year":"2000","unstructured":"Brugada R, Brugada, Antzelevitch C et al (2000) Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts. Circulation 101:510?515","journal-title":"Circulation"},{"key":"CR18","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/32675","volume":"392","author":"Chen","year":"1998","unstructured":"Chen Q, Kirsch GE, Zhang D et al (1998) Genetic basis and molecular mechanisms for idiopathic ventricular fibrillation. Nature 392:293?345","journal-title":"Nature"},{"key":"CR19","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1161\/01.CIR.0000032002.22105.7A","volume":"106","author":"Di Diego","year":"2003","unstructured":"Di Diego JM, Cordeiro M, Goodrow RJ et al (2003) Ionic and cellular basis for the perdominance of the Brugada syndrome phenotype in males. Circulation 106:2004?2011","journal-title":"Circulation"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1046\/j.1540-8167.2002.00880.x","volume":"13","author":"Gasparini","year":"2002","unstructured":"Gasparini M, Priori SG, Mantica et al (2002) Programmed extrastimulation in Brugada syndrome: how reproducible are the results? J Cardiovasc Electrophysiol 13:880?887","journal-title":"J Cardiovasc Electrophysiol"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1253\/jcj.40.753","volume":"40","author":"Gotoh","year":"1976","unstructured":"Gotoh K (1976) A histopathological study on the conduction system of the so-called Pokkuri disease (sudden unexpected cardiac death of unknown origin in Japan). Jpn Circ 40:753?768","journal-title":"Jpn Circ"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0735-1097(98)00528-2","volume":"33","author":"Gussak","year":"1999","unstructured":"Gussak I, Antzelevitch C, Bjerregaard P et al (1999) The Brugada syndrome: clinical, electrophysiological and genetic aspects. J Am Coll Cardiol 33:5?15","journal-title":"J Am Coll Cardiol"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1161\/01.CIR.0000088781.99943.95","volume":"108","author":"Haissaguerre","year":"2003","unstructured":"Haissaguerre M, Extramiana F, Hocini M et al (2003) Mapping and ablation of ventricular fibrillation associated with long-QT and Brugada syndromes. Circulation 108:925?928","journal-title":"Circulation"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1536\/ihj.26.585","volume":"26","author":"Hayashi","year":"1985","unstructured":"Hayashi M, Murata M, Satoh M et al (1985) Sudden nocturnal death in young males from ventricular flutter. Jpn Heart 26:585?591","journal-title":"Jpn Heart"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S0735-1097(00)00932-3","volume":"36","author":"Kakishita","year":"2000","unstructured":"Kakishita M, Kurita T, Matsuo K et al (2000) Mode of onset of ventricular fibrillation in patients with Brugada syndrome detected by implantable cardioverter defibrillator therapy. J Am Coll Cardiol 36:1647?1653","journal-title":"J Am Coll Cardiol"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1054\/jelc.2002.32336","volume":"35","author":"Kataoka","year":"2002","unstructured":"Kataoka H (2002) Electrocardiographic patterns of the Brugada syndrome in 2 young patients with pectus excavatum. J Electrocardiol 35:169?171","journal-title":"J Electrocardiol"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1046\/j.1460-9592.2002.01660.x","volume":"25","author":"Kum","year":"2002","unstructured":"Kum LCC, Fung JWH, Sanderson JE (2002) Brugada syndrome unmasked by febrile illness. PACE 25:1660?1661","journal-title":"PACE"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1161\/hc5001.100834","volume":"104","author":"Kyndt","year":"2001","unstructured":"Kyndt F, Probst V, Potet F et al (2001) Novel SCN5A mutation leading either to isolated cardiac conduction defect or Brugada syndrome in a large French family. Circulation 104:3081?3086","journal-title":"Circulation"},{"key":"CR29","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/0002-8703(89)90011-2","volume":"118","author":"Martini","year":"1989","unstructured":"Martini B, Nava A, Thiene G et al (1989) Ventricular fibrillation without apparent heart disease. Description of six cases. Am Heart J 118:1203?1209","journal-title":"Am Heart J"},{"key":"CR30","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00392-002-0851-x","volume":"91","author":"Martius","year":"2002","unstructured":"Martius P, Kr\u00e4mer H (2002) Brugada oder nicht-Brugada: Fehldiagnose durch ger\u00e4tebedingtes EKG-Artefakt. Z Kardiol 91:1061?1063","journal-title":"Z Kardiol"},{"key":"CR31","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1046\/j.1460-9592.2003.t01-1-00227.x","volume":"26","author":"Matsuo","year":"2003","unstructured":"Matsuo K, Akahoshi M, Seto S et al (2003) Disappearance of the Brugadatype electrocardiogram after surgical castration: a role for testosterone and an explanation for the male preponderance. PACE 26:1551?1553","journal-title":"PACE"},{"key":"CR32","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1046\/j.1540-8167.2003.02379.x","volume":"14","author":"Mok","year":"2003","unstructured":"Mok NS, Priori SG, Napolitano C et al (2003) A newly characterised SCN5A mutation underlying Brugada syndrome unmasked by hyperthermia. J Cardiovasc Electrophysiol 14:412?414","journal-title":"J Cardiovasc Electrophysiol"},{"key":"CR33","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1161\/01.CIR.96.8.2595","volume":"96","author":"Nademanee","year":"1997","unstructured":"Nademanee K, Veerakul G, Nimmannit S et al (1997) Arrhythmogenic marker for the sudden unexplained death syndrome in Thai men. Circulation 96:2595?2600","journal-title":"Circulation"},{"key":"CR34","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1046\/j.1460-9592.2002.01646.x","volume":"25","author":"Porres","year":"2002","unstructured":"Porres M, Brugada P, Urbistondo V et al (2002) Fever unmasking the Brugada syndrome. PACE 25:1646?1648","journal-title":"PACE"},{"key":"CR35","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1161\/hc1102.105288","volume":"105","author":"Priori","year":"2002","unstructured":"Priori SG, Napolitano C, Gasparini M et al (2002) Natural history of Brugada syndrome: insights for risk stratification and management. Circulation 105:1342?1347","journal-title":"Circulation"},{"key":"CR36","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0140-6736(99)05277-0","volume":"355","author":"Priori","year":"2000","unstructured":"Priori SG, Napolitano C, Giordano U et al (2000) Brugada syndrome and sudden cardiac death in children. Lancet 355:808?809","journal-title":"Lancet"},{"key":"CR37","first-page":"203","volume":"53","author":"Sastry","year":"2001","unstructured":"Sastry BKS, Narasimhan C, Somaraju B (2001) Brugada syndrome with monomorphic ventricular tachycardia in a one-year-old child. Indian Heart J 53:203?205","journal-title":"Indian Heart J"},{"key":"CR38","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s00392-002-0804-4","volume":"91","author":"Schmidt","year":"2002","unstructured":"Schmidt Th, Gerckens U, Ortmeyer D et al (2002) Brugada-Syndrom oder ARVD oder beides? Bedeutung und Wertigkeit rechtspr\u00e4kordialer EKG-Ver\u00e4nderungen. Z Kardiol 91:416?422","journal-title":"Z Kardiol"},{"key":"CR39","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1046\/j.1540-8167.2000.01277.x","volume":"11","author":"Suzuki","year":"2000","unstructured":"Suzuki H, Torigoe K, Numata O et al (2000) Infant case with a malignant form of Brugada syndrome. J Cardiovasc Electrophysiol 11:1277?1280","journal-title":"J Cardiovasc Electrophysiol"},{"key":"CR40","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1046\/j.1460-9592.2001.01293.x","volume":"24","author":"Tanaka","year":"2001","unstructured":"Tanaka H, Kinoshita O, Uchikawa S et al (2001) Successful prevention of recurrent ventricular fibrillation by intravenous isoproterenol in a patient with Brugada syndrome. PACE 24:1293?1294","journal-title":"PACE"},{"key":"CR41","first-page":"III\/1","volume":"89","author":"Thierfelder","year":"2000","unstructured":"Thierfelder L (2000) Genetische Aspekte der Arrhythmieentstehung. Z Kardiol 89:(Suppl 3):III\/1?III\/5","journal-title":"Z Kardiol"},{"key":"CR42","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1046\/j.1540-8167.2002.00698.x","volume":"13","author":"Tsuchiya","year":"2002","unstructured":"Tsuchiya T, Ashikaga K, Honda T et al (2002) Prevention of ventricular fibrillation by cilostazol, an oral phosphodiesterase inhibitor, in a patient with Brugada syndrome. J Cardiovasc Electrophysiol 13:698?701","journal-title":"J Cardiovasc Electrophysiol"},{"key":"CR43","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1046\/j.1540-8167.2001.00630.x","volume":"12","author":"Van den Berg","year":"2001","unstructured":"Van den Berg MP, Wilde AAM, Viersma JW et al (2001) Possible bradycardic mode of death and successful pacemaker treatment in a large family with features of long-QT syndrome type 3 and Brugada syndrome. J Cardiovasc Electrophysiol 12:630?636","journal-title":"J Cardiovasc Electrophysiol"},{"key":"CR44","first-page":"626","volume":"98","author":"Veerakul","year":"1996","unstructured":"Veerakul G, Nademanee K (1996) Dynamic changes in the RBBB an STelevation in the right precordial leads observed in patients with idiopathic ventricular fibrillation: evidence of phase 2 repolarization abnormality. Circulation 98(SuppI):626","journal-title":"Circulation"},{"key":"CR45","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1046\/j.1540-8167.2003.03063.x","volume":"14","author":"Viskin","year":"2003","unstructured":"Viskin S (2003) Inducible ventricular fibrillation in the Brugada syndrome: diagnostic and prognostic implications. J Cadiovasc Electrophysiol 14:458?460","journal-title":"J Cadiovasc Electrophysiol"},{"key":"CR46","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1161\/hc0602.103618","volume":"105","author":"Weiss","year":"2002","unstructured":"Weiss R, Barmada MM, Nguyen T et al (2002) Clinical and molecular heterogeneity in the Brugada syndrome: a novel gene locus on chromosome 3. Circulation 105:707?713","journal-title":"Circulation"},{"key":"CR47","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1161\/01.CIR.0000034169.45752.4A","volume":"106","author":"Wilde","year":"2002","unstructured":"Wilde AAM, Anzelevitch C, Borggrefe Met al (2002) Proposed diagnostic criteria for the Brugada syndrome. Consensus report. Circulation 106:2514?2519","journal-title":"Circulation"},{"key":"CR48","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1161\/01.CIR.100.15.1660","volume":"100","author":"Yan","year":"1999","unstructured":"Yan G-X, Anzelevitch C (1999) Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST segment elevation. Circulation 100:1660?1666","journal-title":"Circulation"}],"container-title":["Zeitschrift f\ufffdr Kardiologie"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-004-0122-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00392-004-0122-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-004-0122-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T16:20:15Z","timestamp":1559060415000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00392-004-0122-0"}},"subtitle":["Its relevance to paediatric practice"],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["122"],"URL":"https:\/\/doi.org\/10.1007\/s00392-004-0122-0","relation":{},"ISSN":["0300-5860","1435-1285"],"issn-type":[{"value":"0300-5860","type":"print"},{"value":"1435-1285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}