{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:42:52Z","timestamp":1791916972505,"version":"4.3.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2015,4,18]],"date-time":"2015-04-18T00:00:00Z","timestamp":1429315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1007\/s00392-015-0850-3","type":"journal-article","created":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T12:59:52Z","timestamp":1429275592000},"page":"822-830","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Biological variation, reference change value (RCV) and minimal important difference (MID) of inspiratory muscle strength (PImax) in patients with stable chronic heart failure"],"prefix":"10.1007","volume":"104","author":[{"given":"Tobias","family":"T\u00e4ger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Schell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Cebola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Fr\u00f6hlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"D\u00f6sch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Franke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo A.","family":"Katus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Frank H.","family":"Wians","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutz","family":"Frankenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,4,18]]},"reference":[{"issue":"5","key":"850_CR1","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1378\/chest.98.5.1091","volume":"98","author":"MD Hammond","year":"1990","unstructured":"Hammond MD, Bauer KA, Sharp JT, Rocha RD (1990) Respiratory muscle strength in congestive heart failure. Chest 98(5):1091\u20131094","journal-title":"Chest"},{"issue":"3","key":"850_CR2","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1161\/01.CIR.86.3.909","volume":"86","author":"DM Mancini","year":"1992","unstructured":"Mancini DM, Henson D, LaManca J, Levine S (1992) Respiratory muscle function and dyspnea in patients with chronic congestive heart failure. Circulation 86(3):909\u2013918","journal-title":"Circulation"},{"issue":"4","key":"850_CR3","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s003950070053","volume":"95","author":"FJ Meyer","year":"2000","unstructured":"Meyer FJ, Zugck C, Haass M, Otterspoor L, Strasser RH, Kubler W, Borst MM (2000) Inefficient ventilation and reduced respiratory muscle capacity in congestive heart failure. Basic Res Cardiol 95(4):333\u2013342","journal-title":"Basic Res Cardiol"},{"issue":"8","key":"850_CR4","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1093\/oxfordjournals.eurheartj.a015445","volume":"18","author":"C Witt","year":"1997","unstructured":"Witt C, Borges AC, Haake H, Reindl I, Kleber FX, Baumann G (1997) Respiratory muscle weakness and normal ventilatory drive in dilative cardiomyopathy. Eur Heart J 18(8):1322\u20131328","journal-title":"Eur Heart J"},{"issue":"4","key":"850_CR5","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1016\/0735-1097(94)90858-3","volume":"24","author":"DM Mancini","year":"1994","unstructured":"Mancini DM, Henson D, LaManca J, Levine S (1994) Evidence of reduced respiratory muscle endurance in patients with heart failure. J Am Coll Cardiol 24(4):972\u2013981","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"850_CR6","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1136\/hrt.76.4.332","volume":"76","author":"JT Walsh","year":"1996","unstructured":"Walsh JT, Andrews R, Johnson P, Phillips L, Cowley AJ, Kinnear WJ (1996) Inspiratory muscle endurance in patients with chronic heart failure. Heart 76(4):332\u2013336","journal-title":"Heart"},{"issue":"5","key":"850_CR7","first-page":"435","volume":"23","author":"W Vincken","year":"1987","unstructured":"Vincken W, Ghezzo H, Cosio MG (1987) Maximal static respiratory pressures in adults: normal values and their relationship to determinants of respiratory function. Bulletin Euro de PhysiopatholRes 23(5):435\u2013439","journal-title":"Bulletin Euro de PhysiopatholRes"},{"issue":"1","key":"850_CR8","first-page":"17","volume":"7","author":"N Ambrosino","year":"1994","unstructured":"Ambrosino N, Opasich C, Crotti P, Cobelli F, Tavazzi L, Rampulla C (1994) Breathing pattern, ventilatory drive and respiratory muscle strength in patients with chronic heart failure. Euro Respir J Off J Euro Soc Clin Respir Physiol 7(1):17\u201322","journal-title":"Euro Respir J Off J Euro Soc Clin Respir Physiol"},{"issue":"2","key":"850_CR9","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.ijcard.2010.04.006","volume":"150","author":"A Filusch","year":"2011","unstructured":"Filusch A, Ewert R, Altesellmeier M, Zugck C, Hetzer R, Borst MM, Katus HA, Meyer FJ (2011) Respiratory muscle dysfunction in congestive heart failure\u2013the role of pulmonary hypertension. Int J Cardiol 150(2):182\u2013185. doi:\n                    10.1016\/j.ijcard.2010.04.006","journal-title":"Int J Cardiol"},{"issue":"2","key":"850_CR10","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1378\/chest.105.2.355","volume":"105","author":"Y Nishimura","year":"1994","unstructured":"Nishimura Y, Maeda H, Tanaka K, Nakamura H, Hashimoto Y, Yokoyama M (1994) Respiratory muscle strength and hemodynamics in chronic heart failure. Chest 105(2):355\u2013359","journal-title":"Chest"},{"issue":"4","key":"850_CR11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1590\/S1413-35552012005000034","volume":"16","author":"JP Ribeiro","year":"2012","unstructured":"Ribeiro JP, Chiappa GR, Callegaro CC (2012) The contribution of inspiratory muscles function to exercise limitation in heart failure: pathophysiological mechanisms. Revista brasileira de fisioterapia 16(4):261\u2013267","journal-title":"Revista brasileira de fisioterapia"},{"issue":"2","key":"850_CR12","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s11897-009-0015-7","volume":"6","author":"JP Ribeiro","year":"2009","unstructured":"Ribeiro JP, Chiappa GR, Neder JA, Frankenstein L (2009) Respiratory muscle function and exercise intolerance in heart failure. Curr Heart Failure Reports 6(2):95\u2013101","journal-title":"Curr Heart Failure Reports"},{"issue":"4","key":"850_CR13","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1097\/HJR.0b013e3283030a7e","volume":"16","author":"L Frankenstein","year":"2009","unstructured":"Frankenstein L, Nelles M, Meyer FJ, Sigg C, Schellberg D, Remppis BA, Katus HA, Zugck C (2009) Validity, prognostic value and optimal cutoff of respiratory muscle strength in patients with chronic heart failure changes with beta-blocker treatment. Euro J Cardiovasc Prev Rehabil Off J Euro Soc Cardiol Working Groups Epidemiol Prev Cardiac Rehabil Exerc Physiol 16(4):424\u2013429. doi:\n                    10.1097\/HJR.0b013e3283030a7e","journal-title":"Euro J Cardiovasc Prev Rehabil Off J Euro Soc Cardiol Working Groups Epidemiol Prev Cardiac Rehabil Exerc Physiol"},{"issue":"17","key":"850_CR14","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1161\/01.CIR.103.17.2153","volume":"103","author":"FJ Meyer","year":"2001","unstructured":"Meyer FJ, Borst MM, Zugck C, Kirschke A, Schellberg D, Kubler W, Haass M (2001) Respiratory muscle dysfunction in congestive heart failure: clinical correlation and prognostic significance. Circulation 103(17):2153\u20132158","journal-title":"Circulation"},{"issue":"17","key":"850_CR15","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/j.jacc.2007.12.045","volume":"51","author":"GR Chiappa","year":"2008","unstructured":"Chiappa GR, Roseguini BT, Vieira PJ, Alves CN, Tavares A, Winkelmann ER, Ferlin EL, Stein R, Ribeiro JP (2008) Inspiratory muscle training improves blood flow to resting and exercising limbs in patients with chronic heart failure. J Am Coll Cardiol 51(17):1663\u20131671. doi:\n                    10.1016\/j.jacc.2007.12.045","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"850_CR16","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.jacc.2005.09.052","volume":"47","author":"P Dall\u2019Ago","year":"2006","unstructured":"Dall\u2019Ago P, Chiappa GR, Guths H, Stein R, Ribeiro JP (2006) Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial. J Am Coll Cardiol 47(4):757\u2013763. doi:\n                    10.1016\/j.jacc.2005.09.052","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"850_CR17","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1152\/japplphysiol.01245.2010","volume":"111","author":"RB Jaenisch","year":"2011","unstructured":"Jaenisch RB, Hentschke VS, Quagliotto E, Cavinato PR, Schmeing LA, Xavier LL, Dal Lago P (2011) Respiratory muscle training improves hemodynamics, autonomic function, baroreceptor sensitivity, and respiratory mechanics in rats with heart failure. J Appl Physiol 111(6):1664\u20131670. doi:\n                    10.1152\/japplphysiol.01245.2010","journal-title":"J Appl Physiol"},{"issue":"8","key":"850_CR18","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1053\/euhj.1998.1024","volume":"19","author":"PH Johnson","year":"1998","unstructured":"Johnson PH, Cowley AJ, Kinnear WJ (1998) A randomized controlled trial of inspiratory muscle training in stable chronic heart failure. Eur Heart J 19(8):1249\u20131253","journal-title":"Eur Heart J"},{"issue":"6","key":"850_CR19","first-page":"489","volume":"11","author":"I Laoutaris","year":"2004","unstructured":"Laoutaris I, Dritsas A, Brown MD, Manginas A, Alivizatos PA, Cokkinos DV (2004) Inspiratory muscle training using an incremental endurance test alleviates dyspnea and improves functional status in patients with chronic heart failure. Euro J Cardiovasc Prev Rehabil Off J Euro Soc Cardiol Working Groups Epidemiol Prev Cardiac Rehabil Exerc Physiol 11(6):489\u2013496","journal-title":"Euro J Cardiovasc Prev Rehabil Off J Euro Soc Cardiol Working Groups Epidemiol Prev Cardiac Rehabil Exerc Physiol"},{"key":"850_CR20","doi-asserted-by":"publisher","unstructured":"Laoutaris ID, Adamopoulos S, Manginas A, Panagiotakos DB, Kallistratos MS, Doulaptsis C, Kouloubinis A, Voudris V, Pavlides G, Cokkinos DV, Dritsas A (2013) Benefits of combined aerobic\/resistance\/inspiratory training in patients with chronic heart failure. A complete exercise model? A prospective randomised study. Int J Cardiol\u00a0167(5):1967\u20131972. doi:\n                    10.1016\/j.ijcard.2012.05.019","DOI":"10.1016\/j.ijcard.2012.05.019"},{"issue":"1","key":"850_CR21","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1097\/HJR.0b013e32833c0320","volume":"18","author":"ID Laoutaris","year":"2011","unstructured":"Laoutaris ID, Dritsas A, Adamopoulos S, Manginas A, Gouziouta A, Kallistratos MS, Koulopoulou M, Voudris V, Cokkinos DV, Sfirakis P (2011) Benefits of physical training on exercise capacity, inspiratory muscle function, and quality of life in patients with ventricular assist devices long-term postimplantation. Euro J Cardiovasc Prev Rehabil Off J Euro Soc Cardiol Working Groups Epidemiol Prev Cardiac Rehabil Exerc Physiol 18(1):33\u201340. doi:\n                    10.1097\/HJR.0b013e32833c0320","journal-title":"Euro J Cardiovasc Prev Rehabil Off J Euro Soc Cardiol Working Groups Epidemiol Prev Cardiac Rehabil Exerc Physiol"},{"issue":"2","key":"850_CR22","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/01.HCR.0000314203.09676.b9","volume":"28","author":"ID Laoutaris","year":"2008","unstructured":"Laoutaris ID, Dritsas A, Brown MD, Manginas A, Kallistratos MS, Chaidaroglou A, Degiannis D, Alivizatos PA, Cokkinos DV (2008) Effects of inspiratory muscle training on autonomic activity, endothelial vasodilator function, and N-terminal pro-brain natriuretic peptide levels in chronic heart failure. J Cardiopulm Rehabil Prev 28(2):99\u2013106. doi:\n                    10.1097\/01.HCR.0000314203.09676.b9","journal-title":"J Cardiopulm Rehabil Prev"},{"issue":"2","key":"850_CR23","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1161\/01.CIR.91.2.320","volume":"91","author":"DM Mancini","year":"1995","unstructured":"Mancini DM, Henson D, La Manca J, Donchez L, Levine S (1995) Benefit of selective respiratory muscle training on exercise capacity in patients with chronic congestive heart failure. Circulation 91(2):320\u2013329","journal-title":"Circulation"},{"issue":"1","key":"850_CR24","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/00008483-200301000-00003","volume":"23","author":"TR McConnell","year":"2003","unstructured":"McConnell TR, Mandak JS, Sykes JS, Fesniak H, Dasgupta H (2003) Exercise training for heart failure patients improves respiratory muscle endurance, exercise tolerance, breathlessness, and quality of life. J Cardpulm Rehabil 23(1):10\u201316","journal-title":"J Cardpulm Rehabil"},{"issue":"6","key":"850_CR25","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1097\/HCR.0b013e3181b4cc41","volume":"29","author":"R Stein","year":"2009","unstructured":"Stein R, Chiappa GR, Guths H, Dall\u2019Ago P, Ribeiro JP (2009) Inspiratory muscle training improves oxygen uptake efficiency slope in patients with chronic heart failure. J Cardiopulm Rehabil Prev 29(6):392\u2013395. doi:\n                    10.1097\/HCR.0b013e3181b4cc41","journal-title":"J Cardiopulm Rehabil Prev"},{"issue":"10","key":"850_CR26","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.acvd.2009.05.011","volume":"102","author":"JY Tabet","year":"2009","unstructured":"Tabet JY, Meurin P, Driss AB, Weber H, Renaud N, Grosdemouge A, Beauvais F, Cohen-Solal A (2009) Benefits of exercise training in chronic heart failure. Arch Cardiovasc Dis 102(10):721\u2013730. doi:\n                    10.1016\/j.acvd.2009.05.011","journal-title":"Arch Cardiovasc Dis"},{"issue":"11","key":"850_CR27","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1002\/clc.4960221110","volume":"22","author":"P Weiner","year":"1999","unstructured":"Weiner P, Waizman J, Magadle R, Berar-Yanay N, Pelled B (1999) The effect of specific inspiratory muscle training on the sensation of dyspnea and exercise tolerance in patients with congestive heart failure. Clin Cardiol 22(11):727\u2013732","journal-title":"Clin Cardiol"},{"key":"850_CR28","doi-asserted-by":"publisher","unstructured":"Winkelmann ER, Chiappa GR, Lima CO, Viecili PR, Stein R, Ribeiro JP (2009) Addition of inspiratory muscle training to aerobic training improves cardiorespiratory responses to exercise in patients with heart failure and inspiratory muscle weakness. Am Heart J 158 (5):768e761\u2013768e767. doi:\n                    10.1016\/j.ahj.2009.09.005","DOI":"10.1016\/j.ahj.2009.09.005"},{"issue":"6","key":"850_CR29","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jacc.2005.08.022","volume":"46","author":"SA Hunt","year":"2005","unstructured":"Hunt SA, American College of C, American Heart Association Task Force on Practice G (2005) ACC\/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). J Am Coll Cardiol 46(6):e1\u2013e82. doi:\n                    10.1016\/j.jacc.2005.08.022","journal-title":"J Am Coll Cardiol"},{"key":"850_CR30","doi-asserted-by":"publisher","unstructured":"McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Bohm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez MA, Jaarsma T, Kober L, Lip GY, Maggioni AP, Parkhomenko A, Pieske BM, Popescu BA, Ronnevik PK, Rutten FH, Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA, Zannad F, Zeiher A, Guidelines ESCCfP (2012) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Euro Heart J 33(14):1787\u20131847. doi:\n                    10.1093\/eurheartj\/ehs104","DOI":"10.1093\/eurheartj\/ehs104"},{"issue":"3","key":"850_CR31","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1378\/chest.111.3.802","volume":"111","author":"AS Wen","year":"1997","unstructured":"Wen AS, Woo MS, Keens TG (1997) How many maneuvers are required to measure maximal inspiratory pressure accurately. Chest 111(3):802\u2013807","journal-title":"Chest"},{"key":"850_CR32","doi-asserted-by":"publisher","unstructured":"Harik-Khan RI, Wise RA, Fozard JL (1998) Determinants of maximal inspiratory pressure. The Baltimore longitudinal study of aging. Am J Respir Crit Care Med 158(5 Pt 1):1459\u20131464. doi:\n                    10.1164\/ajrccm.158.5.9712006","DOI":"10.1164\/ajrccm.158.5.9712006"},{"issue":"5","key":"850_CR33","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3109\/10408368909106595","volume":"27","author":"CG Fraser","year":"1989","unstructured":"Fraser CG, Harris EK (1989) Generation and application of data on biological variation in clinical chemistry. Crit Rev Clin Lab Sci 27(5):409\u2013437. doi:\n                    10.3109\/10408368909106595","journal-title":"Crit Rev Clin Lab Sci"},{"issue":"4","key":"850_CR34","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1515\/CCLM.2005.078","volume":"43","author":"N Iglesias","year":"2005","unstructured":"Iglesias N, Petersen PH, Ricos C (2005) Power function of the reference change value in relation to cut-off points, reference intervals and index of individuality. Clin Chem Lab Med CCLM\/FESCC 43(4):441\u2013448. doi:\n                    10.1515\/CCLM.2005.078","journal-title":"Clin Chem Lab Med CCLM\/FESCC"},{"issue":"5","key":"850_CR35","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1097\/00005650-199905000-00006","volume":"37","author":"KW Wyrwich","year":"1999","unstructured":"Wyrwich KW, Nienaber NA, Tierney WM, Wolinsky FD (1999) Linking clinical relevance and statistical significance in evaluating intra-individual changes in health-related quality of life. Med Care 37(5):469\u2013478","journal-title":"Med Care"},{"issue":"9","key":"850_CR36","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/S0895-4356(99)00071-2","volume":"52","author":"KW Wyrwich","year":"1999","unstructured":"Wyrwich KW, Tierney WM, Wolinsky FD (1999) Further evidence supporting an SEM-based criterion for identifying meaningful intra-individual changes in health-related quality of life. J Clin Epidemiol 52(9):861\u2013873","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"850_CR37","first-page":"406","volume":"28","author":"G Wells","year":"2001","unstructured":"Wells G, Beaton D, Shea B, Boers M, Simon L, Strand V, Brooks P, Tugwell P (2001) Minimal clinically important differences: review of methods. J Rheumatol 28(2):406\u2013412","journal-title":"J Rheumatol"},{"issue":"8476","key":"850_CR38","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","volume":"1","author":"JM Bland","year":"1986","unstructured":"Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1(8476):307\u2013310","journal-title":"Lancet"},{"key":"850_CR39","first-page":"67","volume-title":"Biological variation: from principles to practice","author":"CG Fraser","year":"2001","unstructured":"Fraser CG (2001) Changes in serial results. In: Fraser CG (ed) Biological variation: from principles to practice. AACC Press, Washington, pp 67\u201390"},{"key":"850_CR40","doi-asserted-by":"publisher","unstructured":"Ric\u00f3s C, Perich C, Minchinela J, \u00c1lvarez V, Sim\u00f3n M, Biosca C, Dom\u00e9nech M, Fern\u00e1ndez P, Jim\u00e9nez CV, Garcia-Lario JV, Cava F (2009) Application of biological variation\u2014a review. Biochem Med 19(3):250\u2013259. doi:\n                    10.11613\/BM.2009.023","DOI":"10.11613\/BM.2009.023"},{"issue":"2","key":"850_CR41","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1111\/j.1475-6773.2005.0k375.x","volume":"40","author":"HJ Schunemann","year":"2005","unstructured":"Schunemann HJ, Guyatt GH (2005) Commentary\u2013goodbye M(C)ID! Hello MID, where do you come from? Health Serv Res 40(2):593\u2013597. doi:\n                    10.1111\/j.1475-6773.2005.00374.x","journal-title":"Health Serv Res"},{"issue":"2","key":"850_CR42","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1097\/00002281-200203000-00006","volume":"14","author":"DE Beaton","year":"2002","unstructured":"Beaton DE, Boers M, Wells GA (2002) Many faces of the minimal clinically important difference (MCID): a literature review and directions for future research. Curr Opin Rheumatol 14(2):109\u2013114","journal-title":"Curr Opin Rheumatol"}],"container-title":["Clinical Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-015-0850-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00392-015-0850-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-015-0850-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-015-0850-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T01:08:28Z","timestamp":1581988108000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00392-015-0850-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,18]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["850"],"URL":"https:\/\/doi.org\/10.1007\/s00392-015-0850-3","relation":{},"ISSN":["1861-0684","1861-0692"],"issn-type":[{"value":"1861-0684","type":"print"},{"value":"1861-0692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,18]]},"assertion":[{"value":"6 August 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}