{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T22:13:49Z","timestamp":1780697629245,"version":"3.54.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s00392-016-0984-y","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:21:53Z","timestamp":1461284513000},"page":"755-762","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Renal denervation in hypertensive patients not on blood pressure lowering drugs"],"prefix":"10.1007","volume":"105","author":[{"given":"Rosa L.","family":"De Jager","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margreet F.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel L.","family":"Bots","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin D.","family":"Lobo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Ewen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine M. A.","family":"Beeftink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Daemen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"D\u00f6rr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmara","family":"Hering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Mahfoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Nef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland E.","family":"Schmieder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus P.","family":"Schlaich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilko","family":"Spiering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim. A. L.","family":"Tonino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willemien L.","family":"Verloop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva E.","family":"Vink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evert-Jan","family":"Vonken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"Voskuil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Worthley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Blankestijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"984_CR1","doi-asserted-by":"publisher","first-page":"R245","DOI":"10.1152\/ajpregu.00647.2009","volume":"298","author":"GF DiBona","year":"2010","unstructured":"DiBona GF, Esler M (2010) Translational medicine: the antihypertensive effect of renal denervation. Am J Physiol Regul Integr Comp Physiol 298:R245\u2013R253. doi: 10.1152\/ajpregu.00647.2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"984_CR2","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(10)62039-9","volume":"376","author":"MD Esler","year":"2010","unstructured":"Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Bohm M (2010) Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 376:1903\u20131909","journal-title":"Lancet"},{"key":"984_CR3","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1056\/NEJMc0904179","volume":"361","author":"MP Schlaich","year":"2009","unstructured":"Schlaich MP, Sobotka PA, Krum H, Lambert E, Esler MD (2009) Renal sympathetic-nerve ablation for uncontrolled hypertension. N Engl J Med 361:932\u2013934","journal-title":"N Engl J Med"},{"key":"984_CR4","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0140-6736(09)60566-3","volume":"373","author":"H Krum","year":"2009","unstructured":"Krum H, Schlaich M, Whitbourn R, Sobotka PA, Sadowski J, Bartus K et al (2009) Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 373:1275\u20131281","journal-title":"Lancet"},{"key":"984_CR5","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1161\/HYPERTENSIONAHA.114.03605","volume":"64","author":"V Papademetriou","year":"2014","unstructured":"Papademetriou V, Tsioufis CP, Sinhal A, Chew DP, Meredith IT, Malaiapan Y et al (2014) Catheter-based renal denervation for resistant hypertension: 12-month results of the EnligHTN I first-in-human study using a multielectrode ablation system. Hypertension 64:565\u2013572. doi: 10.1161\/HYPERTENSIONAHA.114.03605","journal-title":"Hypertension"},{"key":"984_CR6","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1016\/S0140-6736(14)61942-5","volume":"385","author":"M Azizi","year":"2015","unstructured":"Azizi M, Sapoval M, Gosse P, Monge M, Bobrie G, Delsart P et al (2015) Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (DENERHTN): a multicentre, open-label, randomised controlled trial. Lancet 385:1957\u20131965. doi: 10.1016\/S0140-6736(14)61942-5","journal-title":"Lancet"},{"key":"984_CR7","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1056\/NEJMoa1402670","volume":"370","author":"DL Bhatt","year":"2014","unstructured":"Bhatt DL, Kandzari DE, O\u2019Neill WW, D\u2019Agostino R, Flack JM, Katzen BT et al (2014) A controlled trial of renal denervation for resistant hypertension. N Engl J Med 370:1393\u20131401. doi: 10.1056\/NEJMoa1402670","journal-title":"N Engl J Med"},{"key":"984_CR8","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1093\/eurheartj\/ehu441","volume":"36","author":"DE Kandzari","year":"2015","unstructured":"Kandzari DE, Bhatt DL, Brar S, Devireddy CM, Esler M, Fahy M et al (2015) Predictors of blood pressure response in the SYMPLICITY HTN-3 trial. Eur Heart J 36:219\u2013227. doi: 10.1093\/eurheartj\/ehu441","journal-title":"Eur Heart J"},{"key":"984_CR9","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1161\/CIRCULATIONAHA.113.005405","volume":"129","author":"V Papademetriou","year":"2014","unstructured":"Papademetriou V, Rashidi AA, Tsioufis C, Doumas M (2014) Renal nerve ablation for resistant hypertension: how did we get here, present status, and future directions. Circulation 129:1440\u20131451. doi: 10.1161\/CIRCULATIONAHA.113.005405","journal-title":"Circulation"},{"key":"984_CR10","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1177\/2047487314538859","volume":"22","author":"PJ Blankestijn","year":"2015","unstructured":"Blankestijn PJ, Alings M, Voskuil M, Grobbee DE (2015) The complexity after simplicity: how to proceed with renal denervation in hypertension? Eur J Prev Cardiol 22:412\u2013414","journal-title":"Eur J Prev Cardiol"},{"key":"984_CR11","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/nrcardio.2014.70-c2","volume":"11","author":"RE Schmieder","year":"2014","unstructured":"Schmieder RE (2014) Renal denervation\u2013a valid treatment option despite SYMPLICITY HTN-3. Nat Rev Cardiol 11:638. doi: 10.1038\/nrcardio.2014.70-c2","journal-title":"Nat Rev Cardiol"},{"key":"984_CR12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/00004872-200102000-00022","volume":"19","author":"M Burnier","year":"2001","unstructured":"Burnier M, Schneider MP, Chiolero A, Stubi CL, Brunner HR (2001) Electronic compliance monitoring in resistant hypertension: the basis for rational therapeutic decisions. J Hypertens 19:335\u2013341","journal-title":"J Hypertens"},{"key":"984_CR13","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/HJH.0b013e32835e2286","volume":"31","author":"O Jung","year":"2013","unstructured":"Jung O, Gechter JL, Wunder C, Paulke A, Bartel C, Geiger H et al (2013) Resistant hypertension? Assessment of adherence by toxicological urine analysis. J Hypertens 31:766\u2013774","journal-title":"J Hypertens"},{"key":"984_CR14","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1097\/HJH.0b013e3283652c61","volume":"31","author":"B Strauch","year":"2013","unstructured":"Strauch B, Petrak O, Zelinka T, Rosa J, Somloova Z, Indra T et al (2013) Precise assessment of noncompliance with the antihypertensive therapy in patients with resistant hypertension using toxicological serum analysis. J Hypertens 31:2455\u20132461. doi: 10.1097\/HJH.0b013e3283652c61","journal-title":"J Hypertens"},{"key":"984_CR15","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1161\/HYPERTENSIONAHA.114.03246","volume":"63","author":"FE Fadl Elmula","year":"2014","unstructured":"Fadl Elmula FE, Hoffmann P, Larstorp AC, Fossum E, Brekke M, Kjeldsen SE et al (2014) Adjusted drug treatment is superior to renal sympathetic denervation in patients with true treatment-resistant hypertension. Hypertension 63:991\u2013999. doi: 10.1161\/HYPERTENSIONAHA.114.03246","journal-title":"Hypertension"},{"issue":"2","key":"984_CR16","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/jch.12637","volume":"18","author":"S Antoniou","year":"2015","unstructured":"Antoniou S, Saxena M, Hamedi N, de Cates C, Moghul S, Lidder S et al (2015) Management of hypertensive patients with multiple drug intolerances: a single-center experience of a novel treatment algorithm. J Clin Hypertens (Greenwich)\u00a018(2):129\u2013138. doi: 10.1111\/jch.12637","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"984_CR17","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1097\/01.hjh.0000431740.32696.cc","volume":"31","author":"G Mancia","year":"2013","unstructured":"Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Bohm M et al (2013) 2013 ESH\/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 31:1281\u20131357. doi: 10.1097\/01.hjh.0000431740.32696.cc","journal-title":"J Hypertens"},{"key":"984_CR18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/00126097-200202000-00002","volume":"7","author":"E O\u2019Brien","year":"2002","unstructured":"O\u2019Brien E, Pickering T, Asmar R, Myers M, Parati G, Staessen J et al (2002) Working Group on Blood Pressure Monitoring of the European Society of Hypertension International Protocol for validation of blood pressure measuring devices in adults. Blood Press Monit 7:3\u201317","journal-title":"Blood Press Monit"},{"key":"984_CR19","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1161\/HYPERTENSIONAHA.114.04640","volume":"65","author":"HC Patel","year":"2015","unstructured":"Patel HC, Hayward C, Ozdemir BA, Rosen SD, Krum H, Lyon AR et al (2015) Magnitude of blood pressure reduction in the placebo arms of modern hypertension trials: implications for trials of renal denervation. Hypertension 65:401\u2013406. doi: 10.1161\/HYPERTENSIONAHA.114.04640","journal-title":"Hypertension"},{"key":"984_CR20","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","volume":"130","author":"AS Levey","year":"1999","unstructured":"Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130:461\u2013470","journal-title":"Ann Intern Med"},{"key":"984_CR21","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","volume":"150","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF III, Feldman HI et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150:604\u2013612","journal-title":"Ann Intern Med"},{"key":"984_CR22","doi-asserted-by":"publisher","first-page":"2976","DOI":"10.1161\/CIRCULATIONAHA.112.130880","volume":"126","author":"MD Esler","year":"2012","unstructured":"Esler MD, Krum H, Schlaich M, Schmieder RE, Bohm M, Sobotka PA (2012) Renal sympathetic denervation for treatment of drug-resistant hypertension: one-year results from the Symplicity HTN-2 randomized, controlled trial. Circulation 126:2976\u20132982. doi: 10.1161\/CIRCULATIONAHA.112.130880","journal-title":"Circulation"},{"key":"984_CR23","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1097\/HJH.0b013e328362152e","volume":"31","author":"WL Verloop","year":"2013","unstructured":"Verloop WL, Vink EE, Voskuil M, Vonken EJ, Rookmaaker MB, Bots ML et al (2013) Eligibility for percutaneous renal denervation: the importance of a systematic screening. J Hypertens 31:1662\u20131668","journal-title":"J Hypertens"},{"key":"984_CR24","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1097\/HJH.0000000000000282","volume":"32","author":"EE Vink","year":"2014","unstructured":"Vink EE, Verloop WL, Bost RB, Voskuil M, Spiering W, Vonken EJ et al (2014) The blood pressure-lowering effect of renal denervation is inversely related to kidney function. J Hypertens 32:2045\u20132053. doi: 10.1097\/HJH.0000000000000282","journal-title":"J Hypertens"},{"key":"984_CR25","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.jacc.2014.07.937","volume":"64","author":"AR Tzafriri","year":"2014","unstructured":"Tzafriri AR, Mahfoud F, Keating JH, Markham PM, Spognardi A, Wong G et al (2014) Innervation patterns may limit response to endovascular renal denervation. J Am Coll Cardiol 64:1079\u20131087. doi: 10.1016\/j.jacc.2014.07.937","journal-title":"J Am Coll Cardiol"},{"key":"984_CR26","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1093\/ndt\/gfu192","volume":"29","author":"EE Vink","year":"2014","unstructured":"Vink EE, Goldschmeding R, Vink A, Weggemans C, Bleijs RL, Blankestijn PJ (2014) Limited destruction of renal nerves after catheter-based renal denervation: results of a human case study. Nephrol Dial Transplant 29:1608\u20131610","journal-title":"Nephrol Dial Transplant"},{"key":"984_CR27","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/clc.22008","volume":"35","author":"DE Kandzari","year":"2012","unstructured":"Kandzari DE, Bhatt DL, Sobotka PA, O\u2019Neill WW, Esler M, Flack JM et al (2012) Catheter-based renal denervation for resistant hypertension: rationale and design of the SYMPLICITY HTN-3 Trial. Clin Cardiol 35:528\u2013535","journal-title":"Clin Cardiol"},{"key":"984_CR28","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s00392-013-0627-5","volume":"103","author":"B Vogel","year":"2014","unstructured":"Vogel B, Kirchberger M, Zeier M, Stoll F, Meder B, Saure D et al (2014) Renal sympathetic denervation therapy in the real world: results from the Heidelberg registry. Clin Res Cardiol 103:117\u2013124. doi: 10.1007\/s00392-013-0627-5","journal-title":"Clin Res Cardiol"},{"key":"984_CR29","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0167-5273(92)90238-X","volume":"35","author":"TY Chan","year":"1992","unstructured":"Chan TY, Woo KS, Nicholls MG (1992) The application of nebivolol in essential hypertension: a double-blind, randomized, placebo-controlled study. Int J Cardiol 35:387\u2013395","journal-title":"Int J Cardiol"},{"key":"984_CR30","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.amjhyper.2003.11.003","volume":"17","author":"SG Chrysant","year":"2004","unstructured":"Chrysant SG, Weber MA, Wang AC, Hinman DJ (2004) Evaluation of antihypertensive therapy with the combination of olmesartan medoxomil and hydrochlorothiazide. Am J Hypertens 17:252\u2013259. doi: 10.1016\/j.amjhyper.2003.11.003","journal-title":"Am J Hypertens"},{"key":"984_CR31","unstructured":"U.S. Food and Drug Administration (2002) http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2002\/21-437_Inspra_Medr_P3.pdf . Accessed 1 July 2015"},{"key":"984_CR32","unstructured":"U.S. Food and Drug Administration (2011) http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2011\/200796Orig1s000MedR.pdf . Accessed 1 July 2015"},{"key":"984_CR33","unstructured":"U.S. Food and Drug Adminstration (2002) http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2002\/21-286_Benicar_medr_P2.pdf . Accessed 1 July 2015"},{"key":"984_CR34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1524-6175.2004.03146.x","volume":"6","author":"T Saruta","year":"2004","unstructured":"Saruta T, Kageyama S, Ogihara T, Hiwada K, Ogawa M, Tawara K et al (2004) Efficacy and safety of the selective aldosterone blocker eplerenone in Japanese patients with hypertension: a randomized, double-blind, placebo-controlled, dose-ranging study. J Clin Hypertens (Greenwich) 6:175\u2013183","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"984_CR35","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/j.1524-6175.2007.07548.x","volume":"9","author":"E Saunders","year":"2007","unstructured":"Saunders E, Smith WB, DeSalvo KB, Sullivan WA (2007) The efficacy and tolerability of nebivolol in hypertensive African American patients. J Clin Hypertens (Greenwich) 9:866\u2013875","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"984_CR36","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0895-7061(02)02957-6","volume":"15","author":"MH Weinberger","year":"2002","unstructured":"Weinberger MH, Roniker B, Krause SL, Weiss RJ (2002) Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension. Am J Hypertens 15:709\u2013716","journal-title":"Am J Hypertens"},{"key":"984_CR37","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1161\/HYPERTENSIONAHA.110.163402","volume":"57","author":"WB White","year":"2011","unstructured":"White WB, Weber MA, Sica D, Bakris GL, Perez A, Cao C et al (2011) Effects of the angiotensin receptor blocker azilsartan medoxomil versus olmesartan and valsartan on ambulatory and clinic blood pressure in patients with stages 1 and 2 hypertension. Hypertension 57:413\u2013420. doi: 10.1161\/HYPERTENSIONAHA.110.163402","journal-title":"Hypertension"},{"key":"984_CR38","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0002-9149(03)00461-2","volume":"92","author":"WB White","year":"2003","unstructured":"White WB, Carr AA, Krause S, Jordan R, Roniker B, Oigman W (2003) Assessment of the novel selective aldosterone blocker eplerenone using ambulatory and clinical blood pressure in patients with systemic hypertension. Am J Cardiol 92:38\u201342","journal-title":"Am J Cardiol"},{"key":"984_CR39","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1161\/HYPERTENSIONAHA.114.04019","volume":"65","author":"J Rosa","year":"2015","unstructured":"Rosa J, Widimsky P, Tousek P, Petrak O, Curila K, Waldauf P et al (2015) Randomized comparison of renal denervation versus intensified pharmacotherapy including spironolactone in true-resistant hypertension: six-month results from the Prague-15 study. Hypertension 65:407\u2013413. doi: 10.1161\/HYPERTENSIONAHA.114.04019","journal-title":"Hypertension"},{"key":"984_CR40","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1093\/eurheartj\/ehv192","volume":"36","author":"F Mahfoud","year":"2015","unstructured":"Mahfoud F, Bohm M, Azizi M, Pathak A, Durand ZI, Ewen S et al (2015) Proceedings from the European clinical consensus conference for renal denervation: considerations on future clinical trial design. Eur Heart J 36:2219\u20132227. doi: 10.1093\/eurheartj\/ehv192","journal-title":"Eur Heart J"},{"key":"984_CR41","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1111\/jch.12590","volume":"17","author":"MA Weber","year":"2015","unstructured":"Weber MA, Kirtane A, Mauri L, Townsend RR, Kandzari DE, Leon MB (2015) Renal denervation for the treatment of hypertension: making a new start, getting it right. J Clin Hypertens (Greenwich) 17:743\u2013750. doi: 10.1111\/jch.12590","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"984_CR42","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2307\/2529876","volume":"38","author":"NM Laird","year":"1982","unstructured":"Laird NM, Ware JH (1982) Random-effects models for longitudinal data. Biometrics 38:963\u2013974","journal-title":"Biometrics"}],"container-title":["Clinical Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-016-0984-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00392-016-0984-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-016-0984-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T15:16:38Z","timestamp":1553613398000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00392-016-0984-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,22]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["984"],"URL":"https:\/\/doi.org\/10.1007\/s00392-016-0984-y","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726309516.793517376","asserted-by":"object"}]},"ISSN":["1861-0684","1861-0692"],"issn-type":[{"value":"1861-0684","type":"print"},{"value":"1861-0692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,22]]}}}