{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:41:22Z","timestamp":1789965682807,"version":"4.0.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,6,18]],"date-time":"2016-06-18T00:00:00Z","timestamp":1466208000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1007\/s00392-016-1003-z","type":"journal-article","created":{"date-parts":[[2016,6,18]],"date-time":"2016-06-18T09:54:01Z","timestamp":1466243641000},"page":"944-952","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Sustained clinical benefit of cardiac resynchronization therapy in non-LBBB patients with prolonged PR-interval: MADIT-CRT long-term follow-up"],"prefix":"10.1007","volume":"105","author":[{"given":"Martin","family":"Stockburger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur J.","family":"Moss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut U.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Zareba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Goldenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitschak","family":"Biton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"McNitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Kutyifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,18]]},"reference":[{"issue":"14","key":"1003_CR1","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa0906431","volume":"361","author":"AJ Moss","year":"2009","unstructured":"Moss AJ, Hall WJ, Cannom DS, Klein H, Brown MW, Daubert JP, Estes NA 3rd, Foster E, Greenberg H, Higgins SL, Pfeffer MA, Solomon SD, Wilber D, Zareba W, Trial Investigators MADIT-CRT (2009) Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med 361(14):1329\u20131338","journal-title":"N Engl J Med"},{"issue":"10","key":"1003_CR2","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1161\/CIRCULATIONAHA.110.960898","volume":"123","author":"W Zareba","year":"2011","unstructured":"Zareba W, Klein H, Cygankiewicz I, Hall WJ, McNitt S, Brown M, Cannom D, Daubert JP, Eldar M, Gold MR, Goldberger JJ, Goldenberg I, Lichstein E, Pitschner H, Rashtian M, Solomon S, Viskin S, Wang P, Moss AJ, Investigators MADIT-CRT (2011) Effectiveness of cardiac resynchronization therapy by QRS morphology in the multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT). Circulation 123(10):1061\u20131072","journal-title":"Circulation"},{"issue":"18","key":"1003_CR3","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1056\/NEJMoa1401426","volume":"370","author":"I Goldenberg","year":"2014","unstructured":"Goldenberg I, Kutyifa V, Klein HU, Cannom DS, Brown MW, Dan A, Daubert JP, Estes NA 3rd, Foster E, Greenberg H, Kautzner J, Klempfner R, Kuniss M, Merkely B, Pfeffer MA, Quesada A, Viskin S, McNitt S, Polonsky B, Ghanem A, Solomon SD, Wilber D, Zareba W, Moss AJ (2014) Survival with cardiac-resynchronization therapy in mild heart failure. N Engl J Med 370(18):1694\u20131701","journal-title":"N Engl J Med"},{"issue":"4","key":"1003_CR4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/CIRCEP.113.001299","volume":"7","author":"V Kutyifa","year":"2014","unstructured":"Kutyifa V, Stockburger M, Daubert JP, Holmqvist F, Olshansky B, Schuger C, Klein H, Goldenberg I, Brenyo A, McNitt S, Merkely B, Zareba W, Moss AJ (2014) PR-interval identifies clinical response in patients with non-left bundle branch block: a multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy substudy. Circ Arrhythm Electrophysiol 7(4):645\u2013651","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"1003_CR5","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1093\/eurheartj\/eht150","volume":"34","author":"M Brignole","year":"2013","unstructured":"Brignole M, Auricchio A, Baron-Esquivias G, Bordachar P, Boriani G, Breithardt OA, Cleland J, Deharo JC, Delgado V, Elliott PM, Gorenek B, Israel CW, Leclercq C, Linde C, Mont L, Padeletti L, Sutton R, Vardas PE, ESC Committee for Practice Guidelines (CPG), Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Document Reviewers, Kirchhof P, Blomstrom-Lundqvist C, Badano LP, Aliyev F, B\u00e4nsch D, Baumgartner H, Bsata W, Buser P, Charron P, Daubert JC, Dobreanu D, Faerestrand S, Hasdai D, Hoes AW, Le Heuzey JY, Mavrakis H, McDonagh T, Merino JL, Nawar MM, Nielsen JC, Pieske B, Poposka L, Ruschitzka F, Tendera M, Van Gelder IC, Wilson CM (2013) 2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: the Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). Eur Heart J 34:2281\u20132329","journal-title":"Eur Heart J"},{"issue":"25","key":"1003_CR6","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1056\/NEJMoa1009540","volume":"363","author":"AS Tang","year":"2010","unstructured":"Tang AS, Wells GA, Talajic M, Arnold MO, Sheldon R, Connolly S, Hohnloser SH, Nichol G, Birnie DH, Sapp JL, Yee R, Healey JS, Rouleau JL (2010) Resynchronization-Defibrillation for Ambulatory Heart Failure Trial Investigators. Cardiac-resynchronization therapy for mild-to-moderate heart failure. N Engl J Med 363(25):2385\u20132395","journal-title":"N Engl J Med"},{"issue":"7","key":"1003_CR7","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1161\/CIRCULATIONAHA.112.097709","volume":"126","author":"MR Gold","year":"2012","unstructured":"Gold MR, Th\u00e9bault C, Linde C, Abraham WT, Gerritse B, Ghio S, St John Sutton M, Daubert JC (2012) Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure: results from the Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) study. Circulation 126(7):822\u2013829","journal-title":"Circulation"},{"issue":"6","key":"1003_CR8","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1161\/CIRCHEARTFAILURE.113.000380","volume":"6","author":"DH Birnie","year":"2013","unstructured":"Birnie DH, Ha A, Higginson L, Sidhu K, Green M, Philippon F, Thibault B, Wells G, Tang A (2013) Impact of QRS morphology and duration on outcomes after cardiac resynchronization therapy: results from the Resynchronization-Defibrillation for Ambulatory Heart Failure Trial (RAFT). Circ Heart Fail 6(6):1190\u20131198","journal-title":"Circ Heart Fail"},{"issue":"4 Suppl","key":"1003_CR9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1542-474X.2005.00073.x","volume":"10","author":"AJ Moss","year":"2005","unstructured":"Moss AJ, Brown MW, Cannom DS, Daubert JP, Estes M, Foster E, Greenberg HM, Hall WJ, Higgins SL, Klein H, Pfeffer M, Wilber D, Zareba W (2005) Multicenter automatic defibrillator implantation trial-cardiac resynchronization therapy (MADIT-CRT): design and clinical protocol. Ann Noninvasive Electrocardiol 10(4 Suppl):34\u201343","journal-title":"Ann Noninvasive Electrocardiol"},{"issue":"6","key":"1003_CR10","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0735-1097(85)80335-1","volume":"5","author":"JL Willems","year":"1985","unstructured":"Willems JL, Robles de Medina EO, Bernard R, Coumel P, Fisch C, Krikler D, Mazur NA, Meijler FL, Mogensen L, Moret P, Pisa Z, Rautaharju PM, Surawicz B, Watanabe Y, Wellens HJJ (1985) Criteria for intraventricular conduction disturbances and pre-excitation. World Health Organizational\/International Society and Federation for Cardiology Task Force Ad Hoc. J Am Coll Cardiol 5(6):1261\u20131275","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"1003_CR11","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/0002-9149(93)91017-C","volume":"71","author":"R Schoeller","year":"1993","unstructured":"Schoeller R, Andresen D, Buttner P, Oezcelik K, Vey G, Schroder R (1993) First- or second-degree atrioventricular block as a risk factor in idiopathic dilated cardiomyopathy. Am J Cardiol 71(8):720\u2013726","journal-title":"Am J Cardiol"},{"issue":"1","key":"1003_CR12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.hrthm.2011.07.038","volume":"9","author":"B Olshansky","year":"2012","unstructured":"Olshansky B, Day JD, Sullivan RM, Yong P, Galle E, Steinberg JS (2012) Does cardiac resynchronization therapy provide unrecognized benefit in patients with prolonged PR-intervals? The impact of restoring atrioventricular synchrony: an analysis from the COMPANION Trial. Heart Rhythm 9(1):34\u201339","journal-title":"Heart Rhythm"},{"issue":"24","key":"1003_CR13","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1001\/jama.2009.888","volume":"301","author":"S Cheng","year":"2009","unstructured":"Cheng S, Keyes MJ, Larson MG, McCabe EL, Newton-Cheh C, Levy D, Benjamin EJ, Vasan RS, Wang TJ (2009) Long-term outcomes in individuals with prolonged PR-interval or first-degree atrioventricular block. JAMA 301(24):2571\u20132577","journal-title":"JAMA"},{"key":"1003_CR14","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0002-9149(90)90588-R","volume":"66","author":"M Hochleitner","year":"1990","unstructured":"Hochleitner M, H\u00f6rtnagl H, Ng CK, H\u00f6rtnagl H, Gschnitzer F, Zechmann W (1990) Usefulness of physiologic dual-chamber pacing in drug-resistant idiopathic dilated cardiomyopathy. Am J Cardiol 66:198\u2013202","journal-title":"Am J Cardiol"},{"issue":"15","key":"1003_CR15","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/0002-9149(92)90769-U","volume":"70","author":"M Hochleitner","year":"1992","unstructured":"Hochleitner M, H\u00f6rtnagl H, H\u00f6rtnagl H, Fridrich L, Gschnitzer F (1992) Long-term efficacy of physiologic dual-chamber pacing in the treatment of end-stage idiopathic dilated cardiomyopathy. Am J Cardiol 70(15):1320\u20131325","journal-title":"Am J Cardiol"},{"key":"1003_CR16","doi-asserted-by":"crossref","unstructured":"Kloosterman M, Rienstra M, Mulder BA, Van Gelder IC, Maass AH (2015) Atrial reverse remodelling is associated with outcome of cardiac resynchronization therapy. Europace (Epub ahead of print)","DOI":"10.1093\/europace\/euv382"},{"issue":"15","key":"1003_CR17","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1306687","volume":"369","author":"F Ruschitzka","year":"2013","unstructured":"Ruschitzka F, Abraham WT, Singh JP, Bax JJ, Borer JS, Brugada J, Dickstein K, Ford I, Gorcsan J 3rd, Gras D, Krum H, Sogaard P, Holzmeister J, EchoCRT Study Group (2013) Cardiac-resynchronization therapy in heart failure with a narrow QRS complex. N Engl J Med 369(15):1395\u20131405","journal-title":"N Engl J Med"},{"issue":"2","key":"1003_CR18","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s00392-014-0763-6","volume":"104","author":"D H\u00fcrlimann","year":"2015","unstructured":"H\u00fcrlimann D, Schmidt S, Seifert B, Saguner AM, Hindricks G, L\u00fcscher TF, Ruschitzka F, Steffel J (2015) Outcome of super-responders to cardiac resynchronization therapy defined by endpoint-derived parameters of left ventricular remodeling: a two-center retrospective study. Clin Res Cardiol. 104(2):136\u2013144","journal-title":"Clin Res Cardiol."},{"issue":"4","key":"1003_CR19","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00392-015-0926-0","volume":"105","author":"J Franke","year":"2016","unstructured":"Franke J, Keppler J, Abadei AK, Bajrovic A, Meme L, Zugck C, Raake PW, Zitron E, Katus HA, Frankenstein L (2016) Long-term outcome of patients with and without super-response to CRT-D. Clin Res Cardiol 105(4):341\u2013348","journal-title":"Clin Res Cardiol"}],"container-title":["Clinical Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-016-1003-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00392-016-1003-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-016-1003-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T18:54:47Z","timestamp":1568055287000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00392-016-1003-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,18]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["1003"],"URL":"https:\/\/doi.org\/10.1007\/s00392-016-1003-z","relation":{},"ISSN":["1861-0684","1861-0692"],"issn-type":[{"value":"1861-0684","type":"print"},{"value":"1861-0692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,18]]}}}