{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:22:53Z","timestamp":1790342573201,"version":"4.1.0"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s00392-018-1264-9","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T07:26:35Z","timestamp":1525245995000},"page":"924-936","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Cardiac autonomic modulation impairments in advanced breast cancer patients"],"prefix":"10.1007","volume":"107","author":[{"given":"Claudia","family":"Arab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Carlos Marques","family":"Vanderlei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00e9rcio","family":"da Silva Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle Levi","family":"Fulghum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Elias","family":"Fristachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afonso Celso Pinto","family":"Nazario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Henrique","family":"Gebrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso","family":"Ferreira Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yori","family":"Gidron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,2]]},"reference":[{"key":"1264_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4419-0685-4_1","volume-title":"Breast cancer epidemiology","author":"J Ferlay","year":"2010","unstructured":"Ferlay J, H\u00e9ry C, Autier P, Sankaranarayanan R (2010) Global burden of breast cancer. In: Breast cancer epidemiology. Springer, New York, pp\u00a01\u201319. \n                    https:\/\/doi.org\/10.1007\/978-1-4419-0685-4_1"},{"key":"1264_CR2","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/S0140-6736(16)31392-7","volume":"389","author":"O Ginsburg","year":"2017","unstructured":"Ginsburg O, Bray F, Coleman MP, Vanderpuye V, Eniu A, Kotha SR, Sarker M, Huong TT, Allemani C, Dvaladze A (2017) The global burden of women\u2019s cancers: a grand challenge in global health. Lancet 389:846\u2013860. \n                    https:\/\/doi.org\/10.1016\/S0140-6736(16)31392-7","journal-title":"Lancet"},{"issue":"4","key":"1264_CR3","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s00392-018-1202-x","volume":"107","author":"Lisa M. Tilemann","year":"2018","unstructured":"Tilemann LM, Heckmann MB, Katus HA, Lehmann LH, M\u00fcller OJ (2018) Cardio-oncology: conflicting priorities of anticancer treatment and cardiovascular outcome. Clin Res Cardiol 1\u201310 \n                    https:\/\/doi.org\/10.1007\/s00392-018-1202-x","journal-title":"Clinical Research in Cardiology"},{"key":"1264_CR4","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.ahj.2015.05.014","volume":"170","author":"SG Lakoski","year":"2015","unstructured":"Lakoski SG, Jones LW, Krone RJ, Stein PK, Scott JM (2015) Autonomic dysfunction in early breast cancer: incidence, clinical importance, and underlying mechanisms. Am Heart J 170:231\u2013241. \n                    https:\/\/doi.org\/10.1016\/j.ahj.2015.05.014","journal-title":"Am Heart J"},{"key":"1264_CR5","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1200\/JCO.2010.33.5422","volume":"29","author":"TI Barron","year":"2011","unstructured":"Barron TI, Connolly RM, Sharp L, Bennett K, Visvanathan K (2011) Beta blockers and breast cancer mortality: a population-based study. J Clin Oncol 29:2635\u20132644. \n                    https:\/\/doi.org\/10.1200\/JCO.2010.33.5422","journal-title":"J Clin Oncol"},{"key":"1264_CR6","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1200\/JCO.2010.33.4441","volume":"29","author":"A Melhem-Bertrandt","year":"2011","unstructured":"Melhem-Bertrandt A, Chavez-MacGregor M, Lei X, Brown EN, Lee RT, Meric-Bernstam F, Sood AK, Conzen SD, Hortobagyi GN, Gonzalez-Angulo A-M (2011) Beta-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancer. J Clin Oncol 29:2645\u20132652. \n                    https:\/\/doi.org\/10.1200\/JCO.2010.33.4441","journal-title":"J Clin Oncol"},{"key":"1264_CR7","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s11764-015-0445-z","volume":"9","author":"C Vigo","year":"2015","unstructured":"Vigo C, Gatzemeier W, Sala R, Malacarne M, Santoro A, Pagani M, Lucini D (2015) Evidence of altered autonomic cardiac regulation in breast cancer survivors. J Cancer Surv 9:699\u2013706. \n                    https:\/\/doi.org\/10.1007\/s11764-015-0445-z","journal-title":"J Cancer Surv"},{"key":"1264_CR8","doi-asserted-by":"publisher","first-page":"4014","DOI":"10.1200\/JCO.2010.32.6462","volume":"29","author":"E Colzani","year":"2011","unstructured":"Colzani E, Liljegren A, Johansson AL, Adolfsson J, Hellborg H, Hall PF, Czene K (2011) Prognosis of patients with breast cancer: causes of death and effects of time since diagnosis, age, and tumor characteristics. J Clin Oncol 29:4014\u20134021. \n                    https:\/\/doi.org\/10.1200\/JCO.2010.32.6462","journal-title":"J Clin Oncol"},{"issue":"9","key":"1264_CR9","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1007\/s00392-017-1104-3","volume":"106","author":"C Eick","year":"2017","unstructured":"Eick C, Duckheim M, Groga-Bada P, Klumpp N, Mannes S, Zuern CS, Gawaz M, Rizas KD, Bauer A (2017) Point-of-care testing of cardiac autonomic function for risk assessment in patients with suspected acute coronary syndromes. Clin Res Cardiol 106(9):686\u2013694. \n                    https:\/\/doi.org\/10.1007\/s00392-017-1104-3","journal-title":"Clin Res Cardiol"},{"key":"1264_CR10","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s00392-016-1045-2","volume":"106","author":"A Romanov","year":"2017","unstructured":"Romanov A, Minin S, Breault C, Pokushalov E (2017) Visualization and ablation of the autonomic nervous system corresponding to ganglionated plexi guided by D-SPECT 123 I-mIBG imaging in patient with paroxysmal atrial fibrillation. Clin Res Cardiol 106:76\u201378. \n                    https:\/\/doi.org\/10.1007\/s00392-016-1045-2","journal-title":"Clin Res Cardiol"},{"key":"1264_CR11","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","volume":"93","author":"AJ Camm","year":"1996","unstructured":"Camm AJ, Malik M, Bigger JT, Breithardt G, Cerutti S, Cohen RJ, Coumel P, Fallen EL, Kennedy HL, Kleiger RE, Lombardi F (1996) Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93:1043\u20131065","journal-title":"Circulation"},{"key":"1264_CR12","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1161\/01.CIR.90.2.878","volume":"90","author":"H Tsuji","year":"1994","unstructured":"Tsuji H, Venditti FJ, Manders ES, Evans JC, Larson MG, Feldman CL, Levy D (1994) Reduced heart rate variability and mortality risk in an elderly cohort. Framingham Heart Study Circ 90:878\u2013883","journal-title":"Framingham Heart Study Circ"},{"key":"1264_CR13","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1161\/01.CIR.102.11.1239","volume":"102","author":"JM Dekker","year":"2000","unstructured":"Dekker JM, Crow RS, Folsom AR, Hannan PJ, Liao D, Swenne CA, Schouten EG (2000) Low heart rate variability in a 2-minute rhythm strip predicts risk of coronary heart disease and mortality from several causes. Circulation 102:1239\u20131244. \n                    https:\/\/doi.org\/10.1161\/01.CIR.102.11.1239","journal-title":"Circulation"},{"key":"1264_CR14","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1161\/01.CIR.0000117090.01718.2A","volume":"109","author":"AJ Camm","year":"2004","unstructured":"Camm AJ, Pratt CM, Schwartz PJ, Al-Khalidi HR, Spyt MJ, Holroyde MJ, Karam R, Sonnenblick EH, Brum JM (2004) Mortality in patients after a recent myocardial infarction. Circulation 109:990\u2013996. \n                    https:\/\/doi.org\/10.1161\/01.CIR.0000117090.01718.2A","journal-title":"Circulation"},{"key":"1264_CR15","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1161\/01.CIR.98.15.1510","volume":"98","author":"J Nolan","year":"1998","unstructured":"Nolan J, Batin PD, Andrews R, Lindsay SJ, Brooksby P, Mullen M, Baig W, Flapan AD, Cowley A, Prescott RJ (1998) Prospective study of heart rate variability and mortality in chronic heart failure. Circulation 98:1510\u20131516. \n                    https:\/\/doi.org\/10.1161\/01.CIR.98.15.1510","journal-title":"Circulation"},{"key":"1264_CR16","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1161\/01.CIR.0000047275.25795.17","volume":"107","author":"MT La Rovere","year":"2003","unstructured":"La Rovere MT, Pinna GD, Maestri R, Mortara A, Capomolla S, Febo O, Ferrari R, Franchini M, Gnemmi M, Opasich C (2003) Short-term heart rate variability strongly predicts sudden cardiac death in chronic heart failure patients. Circulation 107:565\u2013570. \n                    https:\/\/doi.org\/10.1161\/01.CIR.0000047275.25795.17","journal-title":"Circulation"},{"key":"1264_CR17","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1093\/europace\/eus341","volume":"15","author":"S Hillebrand","year":"2013","unstructured":"Hillebrand S, Gast KB, Mutsert R, Swenne CA, Jukema JW, Middeldorp S, Rosendaal FR, Dekkers OM (2013) Heart rate variability and first cardiovascular event in populations without known cardiovascular disease: meta-analysis and dose\u2013response meta-regression. Europace 15:742\u2013749. \n                    https:\/\/doi.org\/10.1093\/europace\/eus341","journal-title":"Europace"},{"key":"1264_CR18","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1007\/s00392-017-1120-3","volume":"106","author":"S Bleiziffer","year":"2017","unstructured":"Bleiziffer S, Bosmans J, Brecker S, Gerckens U, Wenaweser P, Tamburino C, Linke A (2017) Insights on mid-term TAVR performance: 3-year clinical and echocardiographic results from the CoreValve ADVANCE study. Clin Res Cardiol 106:784\u2013795. \n                    https:\/\/doi.org\/10.1007\/s00392-017-1120-3","journal-title":"Clin Res Cardiol"},{"key":"1264_CR19","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.ijcard.2016.09.053","volume":"224","author":"MR Palma","year":"2016","unstructured":"Palma MR, Vanderlei LCM, Ribeiro FE, Mantovani AM, Christofaro DGD, Fregonesi CEPT. (2016) The relationship between post-operative time and cardiac autonomic modulation in breast cancer survivors. Intern J Cardiol 224:360\u2013365. \n                    https:\/\/doi.org\/10.1016\/j.ijcard.2016.09.053","journal-title":"Intern J Cardiol"},{"key":"1264_CR20","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s10549-013-2631-x","volume":"140","author":"MV Hansen","year":"2013","unstructured":"Hansen MV, Rosenberg J, G\u00f6genur I (2013) Lack of circadian variation and reduction of heart rate variability in women with breast cancer undergoing lumpectomy: a descriptive study. Breast Cancer Res Treat 140:317\u2013322. \n                    https:\/\/doi.org\/10.1007\/s10549-013-2631-x","journal-title":"Breast Cancer Res Treat"},{"key":"1264_CR21","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1136\/hrt.81.4.419","volume":"81","author":"G Tjeerdsma","year":"1999","unstructured":"Tjeerdsma G, Meinardi M, Van der Graaf W, van Den Berg M, Mulder N, Crijns H, De Vries E, Van Veldhuisen D (1999) Early detection of anthracycline induced cardiotoxicity in asymptomatic patients with normal left ventricular systolic function: autonomic versus echocardiographic variables. Heart 81:419\u2013423","journal-title":"Heart"},{"key":"1264_CR22","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/anec.12108","volume":"19","author":"M Por\u0119ba","year":"2014","unstructured":"Por\u0119ba M, Por\u0119ba R, Ga\u0107 P, Usnarska-Zubkiewicz L, Pilecki W, Piotrowicz E, Piotrowicz R, Rusiecki L, Kuliczkowski K, Mazur G (2014) Heart rate variability and heart rate turbulence in patients with hematologic malignancies subjected to high-dose chemotherapy in the course of hematopoietic stem cell transplantation. Ann Noninvasive Electrocardiol 19:157\u2013165. \n                    https:\/\/doi.org\/10.1111\/anec.12108","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"1264_CR23","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1002\/(SICI)1097-0142(20000501)88:9<2149::AID-CNCR22>3.0.CO;2-Z","volume":"88","author":"EM Ekholm","year":"2000","unstructured":"Ekholm EM, Salminen EK, Huikuri HV, Jalonen J, Antila KJ, Salmi TA, Rantanen VT (2000) Impairment of heart rate variability during paclitaxel therapy. Cancer 88:2149\u20132153. https:\/\/doi.org\/10.1002\/(SICI)1097-0142(20000501)88:9<2149::AID-CNCR22>3.0.CO;2-Z","journal-title":"Cancer"},{"key":"1264_CR24","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.jpainsymman.2009.06.014","volume":"39","author":"N Fadul","year":"2010","unstructured":"Fadul N, Strasser F, Palmer JL, Yusuf SW, Guo Y, Li Z, Allo J, Bruera E (2010) The association between autonomic dysfunction and survival in male patients with advanced cancer: a preliminary report. J Pain Symptom Manage 39:283\u2013290. \n                    https:\/\/doi.org\/10.1016\/j.jpainsymman.2009.06.014","journal-title":"J Pain Symptom Manage"},{"key":"1264_CR25","doi-asserted-by":"publisher","first-page":"503421","DOI":"10.1155\/2013\/503421","volume":"2013","author":"Y-M Wang","year":"2013","unstructured":"Wang Y-M, Wu H-T, Huang E-Y, Kou YR, Hseu S-S (2013) Heart rate variability is associated with survival in patients with brain metastasis: a preliminary report. BioMed Res Int 2013:503421. \n                    https:\/\/doi.org\/10.1155\/2013\/503421","journal-title":"BioMed Res Int"},{"key":"1264_CR26","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.3346\/jkms.2010.25.8.1140","volume":"25","author":"DH Kim","year":"2010","unstructured":"Kim DH, Kim JA, Choi YS, Kim SH, Lee JY, Kim YE (2010) Heart rate variability and length of survival in hospice cancer patients. J Korean Med Sci 25:1140\u20131145. \n                    https:\/\/doi.org\/10.3346\/jkms.2010.25.8.1140","journal-title":"J Korean Med Sci"},{"key":"1264_CR27","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.canep.2015.11.007","volume":"40","author":"M De Couck","year":"2016","unstructured":"De Couck M, Mar\u00e9chal R, Moorthamers S, Van Laethem J-L, Gidron Y (2016) Vagal nerve activity predicts overall survival in metastatic pancreatic cancer, mediated by inflammation. Cancer Epidemiol 40:47\u201351. \n                    https:\/\/doi.org\/10.1016\/j.canep.2015.11.007","journal-title":"Cancer Epidemiol"},{"key":"1264_CR28","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1097\/WNP.0000000000000210","volume":"32","author":"Y Guo","year":"2015","unstructured":"Guo Y, Koshy S, Hui D, Palmer JL, Shin K, Bozkurt M, Yusuf SW (2015) Prognostic value of heart rate variability in patients with cancer. J Clin Neurophysiol 32:516\u2013520. \n                    https:\/\/doi.org\/10.1097\/WNP.0000000000000210","journal-title":"J Clin Neurophysiol"},{"key":"1264_CR29","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1097\/PSY.0000000000000167","volume":"77","author":"J Giese-Davis","year":"2015","unstructured":"Giese-Davis J, Wilhelm FH, Tamagawa R, Palesh O, Neri E, Taylor CB, Kraemer HC, Spiegel D (2015) Higher vagal activity as related to survival in patients with advanced breast cancer: an analysis of autonomic dysregulation. Psychosom Med 77:346\u2013355. \n                    https:\/\/doi.org\/10.1097\/PSY.0000000000000167","journal-title":"Psychosom Med"},{"key":"1264_CR30","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.psyneuen.2016.02.018","volume":"68","author":"C Arab","year":"2016","unstructured":"Arab C, Dias DPM, de Almeida Barbosa RT, de Carvalho TD, Valenti VE, Crocetta TB, Ferreira M, de Abreu LC, Ferreira C (2016) Heart rate variability measure in breast cancer patients and survivors: a systematic review. Psychoneuroendocrinology 68:57\u201368. \n                    https:\/\/doi.org\/10.1016\/j.psyneuen.2016.02.018","journal-title":"Psychoneuroendocrinology"},{"key":"1264_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphys.2011.00095","volume":"2","author":"F Lombardi","year":"2011","unstructured":"Lombardi F, Stein PK (2011) Origin of heart rate variability and turbulence: an appraisal of autonomic modulation of cardiovascular function. Front Physiol 2:1\u20137. \n                    https:\/\/doi.org\/10.3389\/fphys.2011.00095","journal-title":"Front Physiol"},{"key":"1264_CR32","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1046\/j.1365-2281.2001.00342.x","volume":"21","author":"H Bettermann","year":"2001","unstructured":"Bettermann H, Kr\u00f6z M, Girke M, Heckmann C (2001) Heart rate dynamics and cardiorespiratory coordination in diabetic and breast cancer patients. Clin Physiol 21:411\u2013420. \n                    https:\/\/doi.org\/10.1046\/j.1365-2281.2001.00342.x","journal-title":"Clin Physiol"},{"key":"1264_CR33","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1245\/s10434-010-0985-4","volume":"17","author":"SB Edge","year":"2010","unstructured":"Edge SB, Compton CC (2010) The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17:1471\u20131474. \n                    https:\/\/doi.org\/10.1245\/s10434-010-0985-4","journal-title":"Ann Surg Oncol"},{"key":"1264_CR34","doi-asserted-by":"publisher","first-page":"vi7vi23","DOI":"10.1093\/annonc\/mdt284","volume":"24","author":"E Senkus","year":"2013","unstructured":"Senkus E, Kyriakides S, Penault-Llorca F, Poortmans P, Thompson A, Zackrisson S, Cardoso F, ESMO Guidelines Working Group (2013) Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 24:vi7\u2013vi23. \n                    https:\/\/doi.org\/10.1093\/annonc\/mdt284","journal-title":"Ann Oncol"},{"key":"1264_CR35","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S1470-2045(05)70096-6","volume":"6","author":"Y Gidron","year":"2005","unstructured":"Gidron Y, Perry H, Glennie M (2005) Does the vagus nerve inform the brain about preclinical tumours and modulate them? Lancet Oncol 6:245\u2013248. \n                    https:\/\/doi.org\/10.1016\/S1470-2045(05)70096-6","journal-title":"Lancet Oncol"},{"key":"1264_CR36","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/S1470-2045(04)01431-7","volume":"5","author":"F Entschladen","year":"2004","unstructured":"Entschladen F, Drell TL, Lang K, Joseph J, Zaenker KS (2004) Tumour-cell migration, invasion, and metastasis: navigation by neurotransmitters. Lancet Oncol 5:254\u2013258. \n                    https:\/\/doi.org\/10.1016\/S1470-2045(04)01431-7","journal-title":"Lancet Oncol"},{"key":"1264_CR37","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1161\/hc4201.097834","volume":"104","author":"RM Carney","year":"2001","unstructured":"Carney RM, Blumenthal JA, Stein PK, Watkins L, Catellier D, Berkman LF, Czajkowski SM, O\u2019connor C, Stone PH, Freedland KE (2001) Depression, heart rate variability, and acute myocardial infarction. Circulation 104:2024\u20132028. \n                    https:\/\/doi.org\/10.1161\/hc4201.097834","journal-title":"Circulation"},{"key":"1264_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.archger.2015.11.011","volume":"63","author":"MA Almeida-Santos","year":"2016","unstructured":"Almeida-Santos MA, Barreto-Filho JA, Oliveira JLM, Reis FP, da Cunha Oliveira CC, Sousa ACS (2016) Aging, heart rate variability and patterns of autonomic regulation of the heart. Arch Gerontol Geriatr 63:1\u20138. \n                    https:\/\/doi.org\/10.1016\/j.archger.2015.11.011","journal-title":"Arch Gerontol Geriatr"},{"key":"1264_CR39","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1176\/appi.ajp.2014.13121605","volume":"171","author":"AH Kemp","year":"2014","unstructured":"Kemp AH, Brunoni AR, Santos IS, Nunes MA, Dantas EM, Carvalho de Figueiredo R, Pereira AC, Ribeiro AL, Mill JG, Andre\u00e3o RV (2014) Effects of depression, anxiety, comorbidity, and antidepressants on resting-state heart rate and its variability: an ELSA-Brasil cohort baseline study. Am J Psychiatry 171:1328\u20131334. \n                    https:\/\/doi.org\/10.1176\/appi.ajp.2014.13121605","journal-title":"Am J Psychiatry"},{"key":"1264_CR40","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1017\/S0033291714001767","volume":"45","author":"C O\u2019Regan","year":"2015","unstructured":"O\u2019Regan C, Kenny R, Cronin H, Finucane C, Kearney P (2015) Antidepressants strongly influence the relationship between depression and heart rate variability: findings from The Irish Longitudinal Study on Ageing (TILDA). Psychol Med 45:623\u2013636. \n                    https:\/\/doi.org\/10.1017\/S0033291714001767","journal-title":"Psychol Med"},{"key":"1264_CR41","doi-asserted-by":"publisher","first-page":"5","DOI":"10.12820\/RBAFS.V.6N2P5-18","volume":"6","author":"S Matsudo","year":"2012","unstructured":"Matsudo S, Ara\u00fajo T, Matsudo V, Andrade D, Andrade E, Oliveira LC, Braggion G (2012) Question\u00e1rio Internacional De Atividade F\u00edsica (Ipaq): Estupo De Validade E Reprodutibilidade No Brasil. Rev Bras Ativ F\u00eds Sa\u00fade 6:5\u201318. \n                    https:\/\/doi.org\/10.12820\/RBAFS.V.6N2P5-18","journal-title":"Rev Bras Ativ F\u00eds Sa\u00fade"},{"key":"1264_CR42","unstructured":"Committee IR (2005) Guidelines for data processing and analysis of the International Physical Activity Questionnaire (IPAQ)\u2014short and long forms. 1\u201315. \n                    http:\/\/www.ipaq.ki.se\/dloads\/IPAQ%20LS%20Scoring%20Protocols_Nov05.pdf\n                    \n                  . Accessed Dec 2015"},{"key":"1264_CR43","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1590\/S0034-70942007000100006","volume":"57","author":"J\u00c1M Marcolino","year":"2007","unstructured":"Marcolino J\u00c1M, Mathias L, Piccinini Filho L, Guaratini A, Suzuki FM, Alli LAC (2007) Escala hospitalar de ansiedade e depress\u00e3o: estudo da validade de crit\u00e9rio e da confiabilidade com pacientes no pr\u00e9-operat\u00f3rio. Rev Bras Anestesiol 57:52\u201362. \n                    https:\/\/doi.org\/10.1590\/S0034-70942007000100006","journal-title":"Rev Bras Anestesiol"},{"key":"1264_CR44","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","volume":"67","author":"AS Zigmond","year":"1983","unstructured":"Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361\u2013370","journal-title":"Acta Psychiatr Scand"},{"key":"1264_CR45","unstructured":"World Health Organization. Body mass index\u2014BMI. \n                    http:\/\/www.euro.who.int\/en\/health-topics\/disease-prevention\/nutrition\/a-healthy-lifestyle\/body-mass-index-bmi\n                    \n                  . Accessed Mar 2016"},{"key":"1264_CR46","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1249\/MSS.0b013e318184a4b1","volume":"41","author":"D Nunan","year":"2009","unstructured":"Nunan D, Donovan G, Jakovljevic D, Hodges L, Sandercock G, Brodie D (2009) Validity and reliability of short-term heart-rate variability from the Polar S810. Med Sci Sports Exerc 41:243. \n                    https:\/\/doi.org\/10.1249\/MSS.0b013e318184a4b1","journal-title":"Med Sci Sports Exerc"},{"key":"1264_CR47","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1249\/01.mss.0000218135.79476.9c","volume":"38","author":"FX Gamelin","year":"2006","unstructured":"Gamelin FX, Berthoin S, Bosquet L (2006) Validity of the polar S810 heart rate monitor to measure RR intervals at rest. Med Sci Sports Exerc 38:887\u2013893. \n                    https:\/\/doi.org\/10.1249\/01.mss.0000218135.79476.9c","journal-title":"Med Sci Sports Exerc"},{"key":"1264_CR48","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.cmpb.2004.03.004","volume":"76","author":"J-P Niskanen","year":"2004","unstructured":"Niskanen J-P, Tarvainen MP, Ranta-Aho PO, Karjalainen PA (2004) Software for advanced HRV analysis. Comput Methods Progr Biomed 76:73\u201381. \n                    https:\/\/doi.org\/10.1016\/j.cmpb.2004.03.004","journal-title":"Comput Methods Progr Biomed"},{"key":"1264_CR49","unstructured":"Laboratorio deE. Estat\u00edstica-Lee. S\u00e3o Paulo: C\u00e1lculo do tamanho amostral. \n                    http:\/\/www.lee.dante.br\/pesquisa\/amostragem\/qua_2_medias\n                    \n                   Accessed Dec 2015"},{"key":"1264_CR50","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.semcancer.2007.12.002","volume":"18","author":"B Mravec","year":"2008","unstructured":"Mravec B, Gidron Y, Hulin I (2008) Neurobiology of cancer: interactions between nervous, endocrine and immune systems as a base for monitoring and modulating the tumorigenesis by the brain. Semin Cancer Biol 18:150\u2013163. \n                    https:\/\/doi.org\/10.1016\/j.semcancer.2007.12.002","journal-title":"Semin Cancer Biol"},{"key":"1264_CR51","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/S1470-2045(09)70337-7","volume":"11","author":"K Ondicova","year":"2010","unstructured":"Ondicova K, Mravec B (2010) Role of nervous system in cancer aetiopathogenesis. Lancet Oncol 11:596\u2013601. \n                    https:\/\/doi.org\/10.1016\/S1470-2045(09)70337-7","journal-title":"Lancet Oncol"},{"key":"1264_CR52","doi-asserted-by":"publisher","first-page":"1236361","DOI":"10.1126\/science.1236361","volume":"341","author":"C Magnon","year":"2013","unstructured":"Magnon C, Hall SJ, Lin J, Xue X, Gerber L, Freedland SJ, Frenette PS (2013) Autonomic nerve development contributes to prostate cancer progression. Science 341:1236361. \n                    https:\/\/doi.org\/10.1126\/science.1236361","journal-title":"Science"},{"key":"1264_CR53","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nrc3978","volume":"15","author":"SW Cole","year":"2015","unstructured":"Cole SW, Nagaraja AS, Lutgendorf SK, Green PA, Sood AK (2015) Sympathetic nervous system regulation of the tumour microenvironment. Nat Rev Cancer 15:563\u2013572. \n                    https:\/\/doi.org\/10.1038\/nrc3978","journal-title":"Nat Rev Cancer"},{"key":"1264_CR54","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1245\/s10434-006-9049-1","volume":"14","author":"A Maki","year":"2007","unstructured":"Maki A, Kono H, Gupta M, Asakawa M, Suzuki T, Matsuda M, Fujii H, Rusyn I (2007) Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma. Ann Surg Oncol 14:1182\u20131190","journal-title":"Ann Surg Oncol"},{"key":"1264_CR55","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","volume":"454","author":"A Mantovani","year":"2008","unstructured":"Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454:436\u2013444. \n                    https:\/\/doi.org\/10.1038\/nature07205","journal-title":"Nature"},{"key":"1264_CR56","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1073\/pnas.0437939100","volume":"100","author":"E Voronov","year":"2003","unstructured":"Voronov E, Shouval DS, Krelin Y, Cagnano E, Benharroch D, Iwakura Y, Dinarello CA, Apte RN (2003) IL-1 is required for tumor invasiveness and angiogenesis. Proc Natl Acad Sci USA 100:2645\u20132650","journal-title":"Proc Natl Acad Sci USA"},{"key":"1264_CR57","doi-asserted-by":"publisher","first-page":"9471","DOI":"10.1523\/JNEUROSCI.18-22-09471.1998","volume":"18","author":"M Ek","year":"1998","unstructured":"Ek M, Kurosawa M, Lundeberg T, Ericsson A (1998) Activation of vagal afferents after intravenous injection of interleukin-1\u03b2: role of endogenous prostaglandins. J Neurosci 18:9471\u20139479","journal-title":"J Neurosci"},{"key":"1264_CR58","unstructured":"Gidron Y, De Leeuw I, De Couck M, Blase K, Vanacker L (2017) The effects of heart rate variability biofeedback on levels of the tumor marker CEA in metastatic colon cancer: a pilot controlled pilot study. In: The international society for behavior medicine conference, Seville, Spain"},{"key":"1264_CR59","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1002\/ejhf.670","volume":"18","author":"MS Anker","year":"2016","unstructured":"Anker MS, Ebner N, Hildebrandt B, Springer J, Sinn M, Riess H, Anker SD, Landmesser U, Haverkamp W, von Haehling S (2016) Resting heart rate is an independent predictor of death in patients with colorectal, pancreatic, and non-small cell lung cancer: results of a prospective cardiovascular long-term study. Eur J Heart Fail 18:1524\u20131534. \n                    https:\/\/doi.org\/10.1002\/ejhf.670","journal-title":"Eur J Heart Fail"},{"key":"1264_CR60","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s10549-016-3938-1","volume":"159","author":"DH Lee","year":"2016","unstructured":"Lee DH, Park S, Lim SM, Lee MK, Giovannucci EL, Kim JH, Kim SI, Jeon JY (2016) Resting heart rate as a prognostic factor for mortality in patients with breast cancer. Breast Cancer Res Treat 159:375\u2013384. \n                    https:\/\/doi.org\/10.1007\/s10549-016-3938-1","journal-title":"Breast Cancer Res Treat"},{"key":"1264_CR61","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1177\/1099800414568100","volume":"18","author":"E Caro-Mor\u00e1n","year":"2016","unstructured":"Caro-Mor\u00e1n E, Fern\u00e1ndez-Lao C, Galiano-Castillo N, Cantarero-Villanueva I, Arroyo-Morales M, D\u00edaz-Rodr\u00edguez L (2016) Heart rate variability in breast cancer survivors after the first year of treatments a case-controlled study. Biol Res Nurs 18:43\u201349. \n                    https:\/\/doi.org\/10.1177\/1099800414568100","journal-title":"Biol Res Nurs"},{"key":"1264_CR62","doi-asserted-by":"publisher","first-page":"46","DOI":"10.7453\/gahmj.2014.073","volume":"4","author":"R McCraty","year":"2015","unstructured":"McCraty R, Shaffer F (2015) Heart rate variability: new perspectives on physiological mechanisms, assessment of self-regulatory capacity, and health risk. Glob Adv Health Med 4:46\u201361. \n                    https:\/\/doi.org\/10.7453\/gahmj.2014.073","journal-title":"Glob Adv Health Med"},{"key":"1264_CR63","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.neubiorev.2011.11.009","volume":"36","author":"JF Thayer","year":"2012","unstructured":"Thayer JF, \u00c5hs F, Fredrikson M, Sollers JJ, Wager TD (2012) A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health. Neurosci Biobehav Rev 36:747\u2013756. \n                    https:\/\/doi.org\/10.1016\/j.neubiorev.2011.11.009","journal-title":"Neurosci Biobehav Rev"},{"key":"1264_CR64","doi-asserted-by":"publisher","first-page":"e0118308","DOI":"10.1371\/journal.pone.0118308","volume":"10","author":"A Voss","year":"2015","unstructured":"Voss A, Schroeder R, Heitmann A, Peters A, Perz S (2015) Short-term heart rate variability\u2014influence of gender and age in healthy subjects. PloS One 10:e0118308. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0118308","journal-title":"PloS One"},{"key":"1264_CR65","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.amjcard.2003.09.065","volume":"93","author":"I Antelmi","year":"2004","unstructured":"Antelmi I, De Paula RS, Shinzato AR, Peres CA, Mansur AJ, Grupi CJ (2004) Influence of age, gender, body mass index, and functional capacity on heart rate variability in a cohort of subjects without heart disease. Am J Cardiol 93:381\u2013385. \n                    https:\/\/doi.org\/10.1016\/j.amjcard.2003.09.065","journal-title":"Am J Cardiol"},{"key":"1264_CR66","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.psyneuen.2014.03.011","volume":"45","author":"AD Crosswell","year":"2014","unstructured":"Crosswell AD, Lockwood KG, Ganz PA, Bower JE (2014) Low heart rate variability and cancer-related fatigue in breast cancer survivors. Psychoneuroendocrinology 45:58\u201366. \n                    https:\/\/doi.org\/10.1016\/j.psyneuen.2014.03.011","journal-title":"Psychoneuroendocrinology"},{"key":"1264_CR67","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.ijcard.2009.09.543","volume":"141","author":"JF Thayer","year":"2010","unstructured":"Thayer JF, Yamamoto SS, Brosschot JF (2010) The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. Int J Cardiol 141:122\u2013131. \n                    https:\/\/doi.org\/10.1016\/j.ijcard.2009.09.543","journal-title":"Int J Cardiol"},{"key":"1264_CR68","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/s12603-014-0022-6","volume":"18","author":"J Koenig","year":"2014","unstructured":"Koenig J, Jarczok M, Warth M, Ellis R, Bach C, Hillecke T, Thayer JF (2014) Body mass index is related to autonomic nervous system activity as measured by heart rate variability\u2014a replication using short term measurements. J Nutr Health Aging 18:300\u2013302. \n                    https:\/\/doi.org\/10.1007\/s12603-014-0022-6","journal-title":"J Nutr Health Aging"},{"key":"1264_CR69","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1038\/ejcn.2009.35","volume":"63","author":"A Molfino","year":"2009","unstructured":"Molfino A, Fiorentini A, Tubani L, Martuscelli M, Fanelli FR, Laviano A (2009) Body mass index is related to autonomic nervous system activity as measured by heart rate variability. Eur J Clin Nutr 63:1263\u20131265. \n                    https:\/\/doi.org\/10.1038\/ejcn.2009.35","journal-title":"Eur J Clin Nutr"},{"key":"1264_CR70","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/anec.12189","volume":"20","author":"R Zhao","year":"2015","unstructured":"Zhao R, Li D, Zuo P, Bai R, Zhou Q, Fan J, Li C, Wang L, Yang X (2015) Influences of age, gender, and circadian rhythm on deceleration capacity in subjects without evident heart diseases. Ann Noninvasive Electrocardiol 20:158\u2013166. \n                    https:\/\/doi.org\/10.1111\/anec.12189","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"1264_CR71","doi-asserted-by":"publisher","first-page":"H2188-H2193","DOI":"10.1152\/ajpheart.00256.2003","volume":"285","author":"C Liu","year":"2003","unstructured":"Liu C, Kuo TB, Yang CC (2003) Effects of estrogen on gender-related autonomic differences in humans. Am J Physiol Heart Circ Physiol 285:H2188-H2193. \n                    https:\/\/doi.org\/10.1152\/ajpheart.00256.2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1264_CR72","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nrclinonc.2011.110","volume":"8","author":"SA Narod","year":"2011","unstructured":"Narod SA (2011) Hormone replacement therapy and the risk of breast cancer. Nat Rev Clin Oncol 8:669\u2013676","journal-title":"Nat Rev Clin Oncol"},{"key":"1264_CR73","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/S0140-6736(03)14065-2","volume":"362","author":"Million Women Study Collaborators","year":"2003","unstructured":"Million Women Study Collaborators (2003) Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 362:419\u2013427 \n                    https:\/\/doi.org\/10.1016\/S0140-6736(03)14065-2","journal-title":"Lancet"},{"key":"1264_CR74","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1093\/jnci\/djq345","volume":"102","author":"P De","year":"2010","unstructured":"De P, Neutel CI, Olivotto I, Morrison H (2010) Breast cancer incidence and hormone replacement therapy in Canada. J Natl Cancer Inst 102:1489\u20131495. \n                    https:\/\/doi.org\/10.1093\/jnci\/djq345","journal-title":"J Natl Cancer Inst"},{"key":"1264_CR75","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.maturitas.2009.11.005","volume":"65","author":"M Dietel","year":"2010","unstructured":"Dietel M (2010) Hormone replacement therapy (HRT), breast cancer and tumor pathology. Maturitas 65:183\u2013189. \n                    https:\/\/doi.org\/10.1016\/j.maturitas.2009.11.005","journal-title":"Maturitas"},{"issue":"11","key":"1264_CR76","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1007\/s00392-016-0999-4","volume":"105","author":"M Proietti","year":"2016","unstructured":"Proietti M, Nobili A, Raparelli V, Napoleone L, Mannucci PM, Lip GY (2016) Adherence to antithrombotic therapy guidelines improves mortality among elderly patients with atrial fibrillation: insights from the REPOSI study. Clin Res Cardiol 105(11):912\u2013920. \n                    https:\/\/doi.org\/10.1007\/s00392-016-0999-4","journal-title":"Clin Res Cardiol"},{"key":"1264_CR77","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s12890-015-0118-8","volume":"20","author":"YS Tsai","year":"2011","unstructured":"Tsai YS, Lai FC, Chen SR, Jeng C (2011) The influence of physical activity level on heart rate variability among asthmatic adults. J Clin Nurs 20:111\u2013118. \n                    https:\/\/doi.org\/10.1186\/s12890-015-0118-8","journal-title":"J Clin Nurs"},{"key":"1264_CR78","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.1111\/j.1365-2702.2012.04070.x","volume":"21","author":"FC Lai","year":"2012","unstructured":"Lai FC, Chang WL, Jeng C (2012) The relationship between physical activity and heart rate variability in orthotopic heart transplant recipients. J Clin Nurs 21:3235\u20133243. \n                    https:\/\/doi.org\/10.1111\/j.1365-2702.2012.04070.x","journal-title":"J Clin Nurs"},{"key":"1264_CR79","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1089\/jwh.2011.2932","volume":"107","author":"S Reland","year":"2004","unstructured":"Reland S, Ville NS, Sara W, Senhadji L, Carr\u00e9 F (2004) Does the level of chronic physical activity alter heart rate variability in healthy older women? Clin Sci 107:29\u201335. \n                    https:\/\/doi.org\/10.1089\/jwh.2011.2932","journal-title":"Clin Sci"},{"key":"1264_CR80","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1519\/JSC.0000000000000769","volume":"29","author":"TR Gon\u00e7alves","year":"2015","unstructured":"Gon\u00e7alves TR, Farinatti PdTV, Gurgel JL, da Silva Soares PP (2015) Correlation between cardiac autonomic modulation in response to orthostatic stress and indicators of quality of life, physical capacity, and physical activity in healthy individuals. J Strength Cond Res 29:1415\u20131421. \n                    https:\/\/doi.org\/10.1519\/JSC.0000000000000769","journal-title":"J Strength Cond Res"}],"container-title":["Clinical Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00392-018-1264-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-018-1264-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-018-1264-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T19:38:18Z","timestamp":1600285098000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00392-018-1264-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,2]]},"references-count":80,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["1264"],"URL":"https:\/\/doi.org\/10.1007\/s00392-018-1264-9","relation":{},"ISSN":["1861-0684","1861-0692"],"issn-type":[{"value":"1861-0684","type":"print"},{"value":"1861-0692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,2]]},"assertion":[{"value":"12 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The author declares that there is no competing interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}