{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:33:30Z","timestamp":1790429610711,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1007\/s00392-019-01461-7","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T14:04:29Z","timestamp":1556805869000},"page":"1258-1265","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["One year VARC-2-defined clinical outcomes after transcatheter aortic valve implantation with the SAPIEN 3"],"prefix":"10.1007","volume":"108","author":[{"given":"Costanza","family":"Pellegrini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Rheude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Trenkwalder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Patrick","family":"Mayr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Joner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Kastrati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heribert","family":"Schunkert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Husser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hengstenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,2]]},"reference":[{"key":"1461_CR1","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1056\/NEJMoa1103510","volume":"364","author":"CR Smith","year":"2011","unstructured":"Smith CR, Leon MB, Mack MJ et al (2011) Transcatheter versus surgical aortic-valve replacement in high-risk patients. N Engl J Med 364:2187\u20132198","journal-title":"N Engl J Med"},{"key":"1461_CR2","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","volume":"374","author":"MB Leon","year":"2016","unstructured":"Leon MB, Smith CR, Mack MJ et al (2016) Transcatheter or surgical aortic-valve replacement in intermediate-risk patients. N Engl J Med 374:1609\u20131620","journal-title":"N Engl J Med"},{"key":"1461_CR3","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1001\/jama.2015.1474","volume":"313","author":"DR Holmes Jr","year":"2015","unstructured":"Holmes DR Jr, Brennan JM, Rumsfeld JS et al (2015) Clinical outcomes at 1\u00a0year following transcatheter aortic valve replacement. JAMA 313:1019\u20131028","journal-title":"JAMA"},{"key":"1461_CR4","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/j.jcin.2015.08.014","volume":"8","author":"O Husser","year":"2015","unstructured":"Husser O, Pellegrini C, Kessler T et al (2015) Outcomes after transcatheter aortic valve replacement using a novel balloon-expandable transcatheter heart valve: a single-center experience. JACC Cardiovasc Interv 8:1809\u20131816","journal-title":"JACC Cardiovasc Interv"},{"key":"1461_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/24748706.2017.1358832","volume":"1","author":"AH Frangieh","year":"2017","unstructured":"Frangieh AH, Ott I, Michel J et al. (2017) Standardized minimalistic transfemoral transcatheter aortic valve replacement (TAVR) using the SAPIEN 3 device: stepwise description, feasibility, and safety from a large consecutive single-center single-operator cohort. Struct Heart 1:1\u201310","journal-title":"Struct Heart"},{"key":"1461_CR6","doi-asserted-by":"publisher","first-page":"2252","DOI":"10.1093\/eurheartj\/ehw112","volume":"37","author":"S Kodali","year":"2016","unstructured":"Kodali S, Thourani VH, White J et al (2016) Early clinical and echocardiographic outcomes after SAPIEN 3 transcatheter aortic valve replacement in inoperable, high-risk and intermediate-risk patients with aortic stenosis. Eur Heart J 37:2252\u20132262","journal-title":"Eur Heart J"},{"key":"1461_CR7","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1161\/CIRCULATIONAHA.116.022797","volume":"134","author":"HC Herrmann","year":"2016","unstructured":"Herrmann HC, Thourani VH, Kodali SK et al (2016) One-year clinical outcomes with SAPIEN 3 transcatheter aortic valve replacement in high-risk and inoperable patients with severe aortic stenosisclinical perspective. Circulation 134:130\u2013140","journal-title":"Circulation"},{"key":"1461_CR8","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1161\/CIRCULATIONAHA.116.025103","volume":"135","author":"O Wendler","year":"2017","unstructured":"Wendler O, Schymik G, Treede H et al (2017) SOURCE 3 registry: design and 30-day results of the European postapproval registry of the latest generation of the SAPIEN 3 transcatheter heart valve. Circulation 135:1123\u20131132","journal-title":"Circulation"},{"key":"1461_CR9","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1016\/j.jacc.2012.09.001","volume":"60","author":"AP Kappetein","year":"2012","unstructured":"Kappetein AP, Head SJ, G\u00e9n\u00e9reux P et al (2012) Updated standardized endpoint definitions for transcatheter aortic valve implantation: the valve academic research consortium-2 consensus document. J Am Coll Cardiol 60:1438\u20131454","journal-title":"J Am Coll Cardiol"},{"key":"1461_CR10","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.jcin.2015.09.036","volume":"9","author":"O Husser","year":"2016","unstructured":"Husser O, Pellegrini C, Kessler T et al (2016) Predictors of permanent pacemaker implantations and new-onset conduction abnormalities with the SAPIEN 3 balloon-expandable transcatheter heart valve. JACC Cardiovasc Interv 9:244\u2013254","journal-title":"JACC Cardiovasc Interv"},{"key":"1461_CR11","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.jcin.2012.09.019","volume":"6","author":"RK Binder","year":"2013","unstructured":"Binder RK, Rod\u00e9s-Cabau J, Wood DA et al (2013) Transcatheter aortic valve replacement with the SAPIEN 3: a new balloon-expandable transcatheter heart valve. JACC Cardiovasc Interv 6:293\u2013300","journal-title":"JACC Cardiovasc Interv"},{"key":"1461_CR12","first-page":"375","volume":"12","author":"M Erlebach","year":"2016","unstructured":"Erlebach M, Head SJ, Mylotte D et al (2016) VARC endpoint definition compliance rates in contemporary transcatheter aortic valve implantation studies. Euro Interv 12:375\u2013380","journal-title":"Euro Interv"},{"key":"1461_CR13","doi-asserted-by":"publisher","first-page":"e0180815","DOI":"10.1371\/journal.pone.0180815","volume":"12","author":"S Zhang","year":"2017","unstructured":"Zhang S, Kolominsky-Rabas PL (2017) How TAVI registries report clinical outcomes-a systematic review of endpoints based on VARC-2 definitions. PLoS One 12:e0180815","journal-title":"PLoS One"},{"key":"1461_CR14","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1016\/S0140-6736(16)30073-3","volume":"387","author":"VH Thourani","year":"2016","unstructured":"Thourani VH, Kodali S, Makkar RR et al (2016) Transcatheter aortic valve replacement versus surgical valve replacement in intermediate-risk patients: a propensity score analysis. Lancet 387:2218\u20132225","journal-title":"Lancet"},{"key":"1461_CR15","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.1093\/eurheartj\/ehx294","volume":"38","author":"O Wendler","year":"2017","unstructured":"Wendler O, Schymik G, Treede H et al (2017) SOURCE 3: 1-year outcomes post-transcatheter aortic valve implantation using the latest generation of the balloon-expandable transcatheter heart valve. Eur Heart J 38:2717\u20132726","journal-title":"Eur Heart J"},{"key":"1461_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-018-1372-6","author":"A Finkelstein","year":"2018","unstructured":"Finkelstein A, Steinvil A, Rozenbaum Z et al (2018) Efficacy and safety of new-generation transcatheter aortic valves: insights from the Israeli transcatheter aortic valve replacement registry. Clin Res Cardiol. \n                    https:\/\/doi.org\/10.1007\/s00392-018-1372-6","journal-title":"Clin Res Cardiol"},{"key":"1461_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-018-1404-2","author":"D Frank","year":"2018","unstructured":"Frank D, Abdel-Wahab M, Gilard M et al (2018) Characteristics and outcomes of patients \u2264\u200975\u00a0years who underwent transcatheter aortic valve implantation: insights from the SOURCE 3 Registry. Clin Res Cardiol. \n                    https:\/\/doi.org\/10.1007\/s00392-018-1404-2","journal-title":"Clin Res Cardiol"},{"key":"1461_CR18","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s00392-017-1183-1","volume":"107","author":"S Eichler","year":"2018","unstructured":"Eichler S, Salzwedel A, Harnath A et al (2018) Nutrition and mobility predict all-cause mortality in patients 12 months after transcatheter aortic valve implantation. Clin Res Cardiol 107:304\u2013311","journal-title":"Clin Res Cardiol"},{"key":"1461_CR19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885","author":"JJ Popma","year":"2019","unstructured":"Popma JJ, Deeb GM, Yakubov SJ et al (2019) Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients. N Engl J Med. \n                    https:\/\/doi.org\/10.1056\/NEJMoa1816885","journal-title":"N Engl J Med"},{"key":"1461_CR20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052","author":"MJ Mack","year":"2019","unstructured":"Mack MJ, Leon MB, Thourani VH et al (2019) Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients. N Engl J Med. \n                    https:\/\/doi.org\/10.1056\/NEJMoa1814052","journal-title":"N Engl J Med"},{"key":"1461_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28144","author":"C Pellegrini","year":"2019","unstructured":"Pellegrini C, Rheude T, Trenkwalder T et al (2019) One-year clinical outcome with a novel self-expanding transcatheter heart valve. Catheter. Cardiovasc Interv. \n                    https:\/\/doi.org\/10.1002\/ccd.28144","journal-title":"Cardiovasc Interv"},{"key":"1461_CR22","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004088","author":"T Pilgrim","year":"2016","unstructured":"Pilgrim T, Stortecky S, Nietlispach F et al. (2016) Repositionable versus balloon-expandable devices for transcatheter aortic valve implantation in patients with aortic stenosis. J Am Heart Assoc. \n                    https:\/\/doi.org\/10.1161\/JAHA.116.004088","journal-title":"J Am Heart Assoc"},{"key":"1461_CR23","first-page":"30","volume":"2","author":"HA Vohra","year":"2013","unstructured":"Vohra HA, Whistance RN, de Kerchove L, Glineur D, Noirhomme P, El Khoury G (2013) Influence of higher valve gradient on long-term outcome after aortic valve repair. Ann Cardiothorac Surg 2:30\u201339","journal-title":"Ann Cardiothorac Surg"},{"key":"1461_CR24","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-019-01429-7","author":"M Hein","year":"2019","unstructured":"Hein M, Minners J, Jander N et al (2019) Haemodynamic prosthetic valve performance in patients with early leaflet thrombosis after transcatheter aortic valve implantation. Clin Res Cardiol. \n                    https:\/\/doi.org\/10.1007\/s00392-019-01429-7","journal-title":"Clin Res Cardiol"},{"key":"1461_CR25","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1056\/NEJMoa1509233","volume":"373","author":"RR Makkar","year":"2015","unstructured":"Makkar RR, Fontana G, Jilaihawi H et al (2015) Possible subclinical leaflet thrombosis in bioprosthetic aortic valves. N Engl J Med 373:2015\u20132024","journal-title":"N Engl J Med"},{"key":"1461_CR26","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.jacc.2012.03.054","volume":"60","author":"L Buellesfeld","year":"2012","unstructured":"Buellesfeld L, Stortecky S, Heg D et al (2012) Impact of permanent pacemaker implantation on clinical outcome among patients undergoing transcatheter aortic valve implantation. J Am Coll Cardiol 60:493\u2013501","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"1461_CR27","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jcin.2014.07.022","volume":"1","author":"TM Nazif","year":"2015","unstructured":"Nazif TM, Dizon JM, Hahn RT et al (2015) Predictors and clinical outcomes of permanent pacemaker implantation after transcatheter aortic valve replacement: The PARTNER (Placement of AoRtic TraNscathetER Valves) trial and registry. JACC Cardiovasc Interv 1 (8):60\u201369","journal-title":"JACC Cardiovasc Interv"},{"key":"1461_CR28","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1016\/j.jacc.2014.09.026","volume":"64","author":"J Webb","year":"2014","unstructured":"Webb J, Gerosa G, Lef\u00e8vre T et al (2014) Multicenter evaluation of a next-generation balloon-expandable transcatheter aortic valve. J Am Coll Cardiol 64:2235\u20132243","journal-title":"J Am Coll Cardiol"},{"key":"1461_CR29","first-page":"343","volume":"11","author":"G Tarantini","year":"2015","unstructured":"Tarantini G, Mojoli M, Purita P et al (2015) Unravelling the (arte)fact of increased pacemaker rate with the Edwards SAPIEN 3 valve. Euro Interv 11:343\u2013350","journal-title":"Euro Interv"},{"key":"1461_CR30","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/joic.12182","volume":"28","author":"M-I Murray","year":"2015","unstructured":"Murray M-I, Geis N, Pleger ST et al (2015) First experience with the new generation Edwards Sapien 3 aortic bioprosthesis: procedural results and short term outcome. J Interv Cardiol 28:109\u2013116","journal-title":"J Interv Cardiol"},{"key":"1461_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2018.01.011","author":"C Pellegrini","year":"2018","unstructured":"Pellegrini C, Husser O, Kim W-K et al (2018) Predictors of need for permanent pacemaker implantation and conduction abnormalities with a novel self-expanding transcatheter heart valve. Rev Esp Cardiol. \n                    https:\/\/doi.org\/10.1016\/j.rec.2018.01.011","journal-title":"Rev Esp Cardiol"},{"key":"1461_CR32","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s00392-017-1158-2","volume":"107","author":"L Gaede","year":"2018","unstructured":"Gaede L, Kim W-K, Liebetrau C et al (2018) Pacemaker implantation after TAVI: predictors of AV block persistence. Clin Res Cardiol 107:60\u201369","journal-title":"Clin Res Cardiol"},{"key":"1461_CR33","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1007\/s00392-017-1093-2","volume":"106","author":"B Gonska","year":"2017","unstructured":"Gonska B, Seeger J, Ke\u00dfler M, von Keil A, Rottbauer W, W\u00f6hrle J (2017) Predictors for permanent pacemaker implantation in patients undergoing transfemoral aortic valve implantation with the Edwards Sapien 3 valve. Clin Res Cardiol 106:590\u2013597","journal-title":"Clin Res Cardiol"},{"key":"1461_CR34","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jacc.2014.04.033","volume":"64","author":"GCM Siontis","year":"2014","unstructured":"Siontis GCM, J\u00fcni P, Pilgrim T et al (2014) Predictors of permanent pacemaker implantation in patients with severe aortic stenosis undergoing TAVR: a meta-analysis. J Am Coll Cardiol 64:129\u2013140","journal-title":"J Am Coll Cardiol"}],"container-title":["Clinical Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-019-01461-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00392-019-01461-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-019-01461-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,30]],"date-time":"2020-04-30T23:10:16Z","timestamp":1588288216000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00392-019-01461-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,2]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["1461"],"URL":"https:\/\/doi.org\/10.1007\/s00392-019-01461-7","relation":{},"ISSN":["1861-0684","1861-0692"],"issn-type":[{"value":"1861-0684","type":"print"},{"value":"1861-0692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,2]]},"assertion":[{"value":"14 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Dr. Hengstenberg received Proctor fees and speaker honoraria from Edwards Lifesciences. Drs. Husser and Pellegrini received minor travel grants from Edwards Lifesciences. All the other authors have nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All the procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. All patients gave their informed consent prior to the inclusion in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}