{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:06:13Z","timestamp":1784066773270,"version":"3.55.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Servier, the Netherlands"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s00392-020-01607-y","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T18:05:41Z","timestamp":1581012341000},"page":"1155-1164","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Medical treatment of octogenarians with chronic heart failure: data from CHECK-HF"],"prefix":"10.1007","volume":"109","author":[{"name":"for the CHECK-HF investigators","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard C. M.","family":"Linssen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse F.","family":"Veenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Kleberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel J. W.","family":"Grosfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric P.","family":"Viergever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas M.","family":"van Dalen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"de Valk-Bedijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorina","family":"Langerveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Brunner-La Rocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arno W.","family":"Hoes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper J.","family":"Brugts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,6]]},"reference":[{"issue":"10106","key":"1607_CR1","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1016\/S0140-6736(17)31071-1","volume":"390","author":"M Metra","year":"2017","unstructured":"Metra M, Teerlink JR (2017) Heart failure. Lancet 390(10106):1981\u20131995","journal-title":"Lancet"},{"issue":"1","key":"1607_CR2","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/ejhf.30","volume":"16","author":"VM van Deursen","year":"2014","unstructured":"van Deursen VM, Urso R, Laroche C, Damman K, Dahlstr\u00f6m U, Tavazzi L et al (2014) Co-morbidities in patients with heart failure: an analysis of the European Heart Failure Pilot Survey. Eur J Heart Fail 16(1):103\u2013111","journal-title":"Eur J Heart Fail"},{"issue":"12","key":"1607_CR3","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1002\/ejhf.813","volume":"19","author":"O Chioncel","year":"2017","unstructured":"Chioncel O, Lainscak M, Seferovic PM, Anker SD, Crespo-Leiro MG, Harjola VP et al (2017) Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry. Eur J Heart Fail 19(12):1574\u20131585","journal-title":"Eur J Heart Fail"},{"issue":"14","key":"1607_CR4","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","volume":"33","author":"JJ McMurray","year":"2012","unstructured":"McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, B\u00f6hm M, Dickstein K et al (2012) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J 33(14):1787\u20131847","journal-title":"Eur Heart J"},{"issue":"8","key":"1607_CR5","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1002\/ejhf.592","volume":"18","author":"P Ponikowski","year":"2016","unstructured":"Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ et al (2016) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 18(8):891\u2013975","journal-title":"Eur J Heart Fail"},{"issue":"11","key":"1607_CR6","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1002\/ejhf.887","volume":"19","author":"M Komajda","year":"2017","unstructured":"Komajda M, Cowie MR, Tavazzi L, Ponikowski P, Anker SD, Filippatos GS (2017) Physicians' guideline adherence is associated with better prognosis in outpatients with heart failure with reduced ejection fraction: the QUALIFY international registry. Eur J Heart Fail 19(11):1414\u20131423","journal-title":"Eur J Heart Fail"},{"issue":"1","key":"1607_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cger.2006.08.001","volume":"23","author":"S Thomas","year":"2007","unstructured":"Thomas S, Rich MW (2007) Epidemiology, pathophysiology, and prognosis of heart failure in the elderly. Clin Geriatr Med 23(1):1\u201310","journal-title":"Clin Geriatr Med"},{"issue":"3","key":"1607_CR8","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1093\/eurheartj\/ehi115","volume":"26","author":"MD Flather","year":"2005","unstructured":"Flather MD, Shibata MC, Coats AJ, van Veldhuisen DJ, Parkhomenko A, Borbola J et al (2005) Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J 26(3):215\u2013225","journal-title":"Eur Heart J"},{"issue":"7","key":"1607_CR9","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1093\/eurjhf\/hft050","volume":"15","author":"AP Maggioni","year":"2013","unstructured":"Maggioni AP, Dahlstrom U, Filippatos G, Chioncel O, Crespo Leiro M, Drozdz J et al (2013) EURObservational Research Programme: regional differences and 1-year follow-up results of the Heart Failure Pilot Survey (ESC-HF Pilot). Eur J Heart Fail 15(7):808\u2013817","journal-title":"Eur J Heart Fail"},{"issue":"11","key":"1607_CR10","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1001\/jama.297.11.1233","volume":"297","author":"HG Van Spall","year":"2007","unstructured":"Van Spall HG, Toren A, Kiss A, Fowler RA (2007) Eligibility criteria of randomized controlled trials published in high-impact general medical journals: a systematic sampling review. JAMA 297(11):1233\u20131240","journal-title":"JAMA"},{"issue":"11","key":"1607_CR11","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1093\/eurheartj\/ehl443","volume":"28","author":"M Komajda","year":"2007","unstructured":"Komajda M, Hanon O, Hochadel M, Follath F, Swedberg K, Gitt A et al (2007) Management of octogenarians hospitalized for heart failure in Euro Heart Failure Survey I. Eur Heart J 28(11):1310\u20131318","journal-title":"Eur Heart J"},{"issue":"4","key":"1607_CR12","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1093\/eurheartj\/ehn539","volume":"30","author":"M Komajda","year":"2009","unstructured":"Komajda M, Hanon O, Hochadel M, Lopez-Sendon JL, Follath F, Ponikowski P et al (2009) Contemporary management of octogenarians hospitalized for heart failure in Europe: Euro Heart Failure Survey II. Eur Heart J 30(4):478\u2013486","journal-title":"Eur Heart J"},{"issue":"4","key":"1607_CR13","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1177\/2047487312444235","volume":"20","author":"G Moubarak","year":"2013","unstructured":"Moubarak G, Ernande L, Godin M, Cazeau S, Vicaut E, Hanon O et al (2013) Impact of comorbidity on medication use in elderly patients with cardiovascular diseases: the OCTOCARDIO study. Eur J Prev Cardiol 20(4):524\u2013530","journal-title":"Eur J Prev Cardiol"},{"issue":"2","key":"1607_CR14","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00228-014-1794-7","volume":"71","author":"C Vorilhon","year":"2015","unstructured":"Vorilhon C, Chenaf C, Mulliez A, Pereira B, Clerfond G, Authier N et al (2015) Heart failure prognosis and management in over-80-year-old patients: data from a French national observational retrospective cohort. Eur J Clin Pharmacol 71(2):251\u2013260","journal-title":"Eur J Clin Pharmacol"},{"issue":"1","key":"1607_CR15","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.ejim.2015.08.015","volume":"27","author":"M Mizuno","year":"2016","unstructured":"Mizuno M, Kajimoto K, Sato N, Yumino D, Minami Y, Murai K et al (2016) Clinical profile, management, and mortality in very-elderly patients hospitalized with acute decompensated heart failure: an analysis from the ATTEND registry. Eur J Intern Med 27(1):80\u201385","journal-title":"Eur J Intern Med"},{"issue":"48","key":"1607_CR16","doi-asserted-by":"publisher","first-page":"4257","DOI":"10.1093\/eurheartj\/ehy621","volume":"39","author":"G Savarese","year":"2018","unstructured":"Savarese G, Dahlstr\u00f6m U, Vasko P, Pitt B, Lund LH (2018) Association between renin-angiotensin system inhibitor use and mortality\/morbidity in elderly patients with heart failure with reduced ejection fraction: a prospective propensity score-matched cohort study. Eur Heart J 39(48):4257\u20134265","journal-title":"Eur Heart J"},{"key":"1607_CR17","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1615","author":"D Stolfo","year":"2019","unstructured":"Stolfo D, Uijl A, Benson L, Schrage B, Fudim M, Asselbergs FW et al. (2019) Association between beta-blocker use and mortality\/morbidity in older patients with heart failure with reduced ejection fraction. A propensity score-matched analysis from the Swedish Heart Failure Registry. Eur J Heart Fail Sep. https:\/\/doi.org\/10.1002\/ejhf.1615","journal-title":"Eur J Heart Fail Sep"},{"issue":"4","key":"1607_CR18","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.jacc.2018.04.070","volume":"72","author":"SJ Greene","year":"2018","unstructured":"Greene SJ, Butler J, Albert NM, DeVore AD, Sharma PP, Duffy CI et al (2018) Medical therapy for heart failure with reduced ejection fraction: the CHAMP-HF Registry. J Am Coll Cardiol 72(4):351\u2013366","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"1607_CR19","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1007\/s12471-018-1103-7","volume":"26","author":"JJ Brugts","year":"2018","unstructured":"Brugts JJ, Linssen GCM, Hoes AW, Brunner-La Rocca HP, Investigators of CHECK-HF (2018) Real-world heart failure management in 10,910 patients with chronic heart failure in the Netherlands: design and rationale of the Chronic Heart failure ESC guideline-based Cardiology practice Quality project (CHECK-HF) registry. Neth Heart J 26(5):272\u2013279","journal-title":"Neth Heart J"},{"issue":"1","key":"1607_CR20","first-page":"13","volume":"7","author":"HP Brunner-La Rocca","year":"2019","unstructured":"Brunner-La Rocca HP, Linssen GC, Smeele FJ, van Drimmelen AA, Schaafsma HJ, Westendorp PH et al (2019) Contemporary drug treatment of chronic heart failure with reduced ejection fraction. The CHECK-HF registry. J Am Coll Cardiol HF 7(1):13\u201321","journal-title":"J Am Coll Cardiol HF"},{"key":"1607_CR21","unstructured":"National Cardiac Audit Programme (2018) National Heart Failure Audit 2016\/17 Summary Report. https:\/\/www.nicor.org.uk\/wp-content\/uploads\/2018\/11\/Heart-Failure-Summary-Report-2016-17.pdf"},{"issue":"10205","key":"1607_CR22","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/S0140-6736(19)31792-1","volume":"394","author":"BT Santema","year":"2019","unstructured":"Santema BT, Ouwerkerk W, Tromp J, Sama IE, Ravera A, Regitz-Zagrosek V et al (2019) Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study. Lancet 394(10205):1254\u20131263","journal-title":"Lancet"},{"issue":"9","key":"1607_CR23","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1002\/ejhf.1182","volume":"20","author":"G Savarese","year":"2018","unstructured":"Savarese G, Carrero JJ, Pitt B, Anker SD, Rosano GMC, Dahlstr\u00f6m U et al (2018) Factors associated with underuse of mineralocorticoid receptor antagonists in heart failure with reduced ejection fraction: an analysis of 11 215 patients from the Swedish Heart Failure Registry. Eur J Heart Fail 20(9):1326\u20131334","journal-title":"Eur J Heart Fail"},{"issue":"6","key":"1607_CR24","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.ahj.2009.03.010","volume":"157","author":"DE Forman","year":"2009","unstructured":"Forman DE, Cannon CP, Hernandez AF, Liang L, Yancy C, Fonarow GC (2009) Influence of age on the management of heart failure: findings from Get With the Guidelines-Heart Failure (GWTG-HF). Am Heart J 157(6):1010\u20131017","journal-title":"Am Heart J"},{"issue":"4","key":"1607_CR25","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1001\/jama.2009.2","volume":"301","author":"M Pfisterer","year":"2009","unstructured":"Pfisterer M, Buser P, Rickli H, Gutmann M, Erne P, Rickenbacher P et al (2009) BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial. JAMA 301(4):383\u2013392","journal-title":"JAMA"},{"issue":"12","key":"1607_CR26","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1002\/ejhf.401","volume":"17","author":"HP Brunner-La Rocca","year":"2015","unstructured":"Brunner-La Rocca HP, Eurlings L, Richards AM, Januzzi JL, Pfisterer ME, Dahlstr\u00f6m U et al (2015) Which heart failure patients profit from natriuretic peptide guided therapy? A meta-analysis from individual patient data of randomized trials. Eur J Heart Fail 17(12):1252\u20131261","journal-title":"Eur J Heart Fail"},{"issue":"24","key":"1607_CR27","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1093\/eurheartj\/ehx026","volume":"38","author":"W Ouwerkerk","year":"2017","unstructured":"Ouwerkerk W, Voors AA, Anker SD, Cleland JG, Dickstein K, Filippatos G et al (2017) Determinants and clinical outcome of uptitration of ACE-inhibitors and beta-blockers in patients with heart failure: a prospective European study. Eur Heart J 38(24):1883\u20131890","journal-title":"Eur Heart J"},{"issue":"7","key":"1607_CR28","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1002\/ejhf.518","volume":"18","author":"MT Vidan","year":"2016","unstructured":"Vidan MT, Blaya-Novakova V, Sanchez E, Ortiz J, Serra-Rexach JA, Bueno H (2016) Prevalence and prognostic impact of frailty and its components in non-dependent elderly patients with heart failure. Eur J Heart Fail 18(7):869\u2013875","journal-title":"Eur J Heart Fail"},{"issue":"6","key":"1607_CR29","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1093\/ageing\/afu138","volume":"43","author":"G Turner","year":"2014","unstructured":"Turner G, Clegg A (2014) Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report. Age Ageing 43(6):744\u2013748","journal-title":"Age Ageing"},{"issue":"6","key":"1607_CR30","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1093\/eurheartj\/ehr404","volume":"33","author":"HP Brunner-La Rocca","year":"2012","unstructured":"Brunner-La Rocca HP, Rickenbacher P, Muzzarelli S, Schindler R, Maeder MT, Jeker U et al (2012) End-of-life preferences of elderly patients with chronic heart failure. Eur Heart J 33(6):752\u2013759","journal-title":"Eur Heart J"},{"issue":"20","key":"1607_CR31","doi-asserted-by":"publisher","first-page":"2108","DOI":"10.1001\/jama.2012.14785","volume":"308","author":"LH Lund","year":"2012","unstructured":"Lund LH, Benson L, Dahlstr\u00f6m U, Edner M (2012) Association between use of renin-angiotensin system antagonists and mortality in patients with heart failure and preserved ejection fraction. JAMA 308(20):2108\u20132117","journal-title":"JAMA"},{"issue":"19","key":"1607_CR32","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1001\/jama.2014.15241","volume":"312","author":"LH Lund","year":"2014","unstructured":"Lund LH, Benson L, Dahlstr\u00f6m U, Edner M, Friberg L (2014) Association between use of \u03b2-blockers and outcomes in patients with heart failure and preserved ejection fraction. JAMA 312(19):2008\u20132018","journal-title":"JAMA"},{"issue":"37","key":"1607_CR33","doi-asserted-by":"publisher","first-page":"3417","DOI":"10.1093\/eurheartj\/ehy407","volume":"39","author":"CJ Rush","year":"2018","unstructured":"Rush CJ, Campbell RT, Jhund PS, Petrie MC, McMurray JJV (2018) Association is not causation: treatment effects cannot be estimated from observational data in heart failure. Eur Heart J 39(37):3417\u20133438","journal-title":"Eur Heart J"}],"container-title":["Clinical Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-020-01607-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00392-020-01607-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-020-01607-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T02:01:36Z","timestamp":1612490496000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00392-020-01607-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,6]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["1607"],"URL":"https:\/\/doi.org\/10.1007\/s00392-020-01607-y","relation":{},"ISSN":["1861-0684","1861-0692"],"issn-type":[{"value":"1861-0684","type":"print"},{"value":"1861-0692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,6]]},"assertion":[{"value":"4 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing financial interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}