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Morphological echo analysis was performed to determine predictors of MR improvement.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>15.2% of patients presented with baseline MR\u2009\u2265\u20093\u2009+, which was associated with a significantly decreased 2-year survival (57.7% vs. 74.4%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). MR improved in 50% of patients following TAVR, with 44% regressing to MR\u2009\u2264\u20092\u2009+. MR improvement to\u2009\u2264\u20092\u2009+\u2009was associated with significantly better survival compared to patients with persistent MR\u2009\u2265\u20093\u2009+. Baseline parameters including non-severe baseline MR, the extent of mitral annular calcification and large annular dimension (\u2265\u200932\u00a0mm) predicted the likelihood of an improvement to MR\u2009\u2264\u20092\u2009+. A score based on these parameters selected groups with differing probability of MR\u2009\u2264\u20092\u2009+\u2009post TAVR ranging from 10.5 to 94.4% (AUC 0.816; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and was predictive for 2-year mortality.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Unresolved severe MR is a critical determinant of long term mortality following TAVR. Persistence of severe MR following TAVR can be predicted using selected parameters derived from TTE-imaging. These data call for close follow up and additional mitral valve treatment in this subgroup.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Graphic abstract<\/jats:title>\n<jats:p>Factors associated with MR persistence or regression after TAVR\n<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00392-020-01618-9","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T14:03:04Z","timestamp":1582034584000},"page":"1261-1270","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Prognosis of persistent mitral regurgitation in patients undergoing transcatheter aortic valve replacement"],"prefix":"10.1007","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2678-3501","authenticated-orcid":false,"given":"Victor","family":"Mauri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"K\u00f6rber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Frerker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Wahlers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja K.","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"ten Freyhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"1618_CR1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001822","author":"F Bedogni","year":"2013","unstructured":"Bedogni F, Latib A, De Marco F et al (2013) Interplay between mitral regurgitation and transcatheter aortic valve replacement with the corevalve revalving system: a multicenter registry. 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CF received speakers\u2019 honoraria and travel support from Medtronic, Abbott Vascular, Edwards Lifesciences and Boston Scientific. TR received speakers\u2019 honoraria from Edwards Lifesciences, Medtronic and Boston Scientific. SB received research funding from Abbot and speakers\u2019 honoraria from Abbott Vascular and Edwards Lifesciences. MA received speakers\u2019 honoraria from Medtronic. All other authors declare no potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}