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This study investigated the 5-year results of heart rate control with ivabradine or metoprolol succinate in patients after HTX.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This registry study analyzed 104 patients receiving either ivabradine (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200950) or metoprolol succinate (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200954) within 5\u00a0years after HTX. Analysis included patient characteristics, medication, echocardiographic features, cardiac catheterization data, cardiac biomarkers, heart rates, and post-transplant survival including causes of death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Demographics and post-transplant medication revealed no significant differences except for ivabradine and metoprolol succinate use. At 5-year follow-up, patients with ivabradine had a significantly lower heart rate (73.3\u00a0bpm) compared to baseline (88.6\u00a0bpm;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) and to metoprolol succinate (80.4\u00a0bpm;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), a reduced left ventricular mass (154.8\u00a0g) compared to baseline (179.5\u00a0g;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) and to metoprolol succinate (177.3\u00a0g;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), a lower left ventricular end-diastolic pressure (LVEDP; 12.0\u00a0mmHg) compared to baseline (15.5\u00a0mmHg;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) and to metoprolol succinate (17.1\u00a0mmHg;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), and a reduced NT-proBNP level (525.4\u00a0pg\/ml) compared to baseline (3826.3\u00a0pg\/ml;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) and to metoprolol succinate (1038.9\u00a0pg\/ml;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Five-year post-transplant survival was significantly better in patients with ivabradine (90.0%) versus metoprolol succinate (68.5%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients receiving ivabradine showed a superior heart rate reduction and a better left ventricular diastolic function along with an improved 5-year survival after HTX.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-020-01692-z","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T15:03:51Z","timestamp":1592838231000},"page":"141-153","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Five-year results of heart rate control with ivabradine or metoprolol succinate in patients after heart transplantation"],"prefix":"10.1007","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1146-6319","authenticated-orcid":false,"given":"Rasmus","family":"Rivinius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Helmschrott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Kathrin","family":"Rahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice F.","family":"Darche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dierk","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Bruckner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas O.","family":"Doesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo A.","family":"Katus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Ehlermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"issue":"9744","key":"1692_CR1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0140-6736(10)61259-7","volume":"376","author":"M B\u00f6hm","year":"2010","unstructured":"B\u00f6hm M, Swedberg K, Komajda M et al (2010) Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial. 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