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The aim of this observational study was to characterize the myocardial effects during SARS-CoV-2 infections by echocardiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and methods<\/jats:title><jats:p>An extended echocardiographic image acquisition protocol was performed in 18 patients with SARS-CoV-2 infection assessing LV longitudinal, radial, and circumferential deformation including rotation, twist, and untwisting. Furthermore, LV deformation was analyzed in an age-matched control group of healthy individuals (<jats:italic>n<\/jats:italic>\u2009=\u200920). The most prevalent finding was a reduced longitudinal strain observed predominantly in more than one basal LV segment (<jats:italic>n<\/jats:italic>\u2009=\u200910\/14 patients, 71%). This pattern reminded of a \u201creverse tako-tsubo\u201d morphology that is not typical for other viral myocarditis. Additional findings included a biphasic pattern with maximum post-systolic or negative regional radial strain predominantly basal (<jats:italic>n<\/jats:italic>\u2009=\u20095\/14 patients, 36%); the absence or dispersion of basal LV rotation (<jats:italic>n<\/jats:italic>\u2009=\u20096\/14 patients, 43%); a reduced or positive regional circumferential strain in more than one segment (<jats:italic>n<\/jats:italic>\u2009=\u20097\/14 patients, 50%); a net rotation showing late post-systolic twist or biphasic pattern (<jats:italic>n<\/jats:italic>\u2009=\u20098\/14 patients, 57%); a net rotation showing polyphasic pattern and\/or higher maximum net values during diastole (<jats:italic>n<\/jats:italic>\u2009=\u20098\/14 patients, 57%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Myocardial involvement due to SARS-CoV-2-infection was highly prevalent in the present cohort\u2014even in patients with mild symptoms. It appears to be characterized by specific speckle tracking deformation abnormalities in the basal LV segments. 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