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Combined targeting of relevant neural outflows may provide a unique therapeutic opportunity for cardiometabolic disease.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>We aimed to investigate the feasibility, safety, and performance of a novel device-based approach for multi-organ denervation in a swine model over 30 and 90\u00a0days of follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Five Yorkshire cross pigs underwent combined percutaneous denervation in the renal arteries and the common hepatic artery (CHA) with the iRF Denervation System. Control animals (<jats:italic>n<\/jats:italic>\u2009=\u20093) were also studied. Specific energy doses were administered in the renal arteries and CHA. Blood was collected at 30 and 90\u00a0days. All animals had a pre-terminal procedure angiography. Tissue samples were collected for norepinephrine (NEPI) bioanalysis. Histopathological evaluation of collateral structures and tissues near the treatment sites was performed to assess treatment safety.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All animals entered and exited the study in good health. No stenosis or vessel abnormalities were present. No significant changes in serum chemistry occurred. NEPI concentrations were significantly reduced in the liver (\u2212\u200988%, <jats:italic>p<\/jats:italic>\u2009=\u20090.005), kidneys (\u2212\u200978%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), pancreas (\u2212\u200978%, <jats:italic>p<\/jats:italic>\u2009=\u20090.018) and duodenum (\u2212\u200995%, <jats:italic>p<\/jats:italic>\u2009=\u20090.028) following multi-organ denervation treatment compared to control animals. Histologic findings were consistent with favourable tissue responses at 90\u00a0days follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Significant and sustained denervation of the treated organs was achieved at 90\u00a0days without major safety events. Our findings demonstrate the feasibility of multi-organ denervation using a novel iRF Denervation System in a single procedure.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00392-021-01814-1","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T09:03:07Z","timestamp":1614330187000},"page":"740-753","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Combined renal and common hepatic artery denervation as a novel approach to reduce cardiometabolic risk: technical approach, feasibility and safety in a pre-clinical model"],"prefix":"10.1007","volume":"110","author":[{"given":"M\u00e1rcio Galindo","family":"Kiuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavitha","family":"Ganesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Keating","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revathy","family":"Carnagarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vance B.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshini Y.","family":"Herat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Goh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-0195","authenticated-orcid":false,"given":"Markus P.","family":"Schlaich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"1814_CR1","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1097\/00004872-199816121-00019","volume":"16","author":"G Grassi","year":"1998","unstructured":"Grassi G (1998) Role of the sympathetic nervous system in human hypertension. 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KG is an employee of Metavention. JK is an employee of CBSET Inc. RC is supported by the postdoctoral fellowship from National Heart Foundation. VM and LH have no conflict of interest. GG serves on Advisory Board for Metavention. LA serves on Advisory Boards for Pfizer and Metavention. MPS is supported by an NHMRC Research Fellowship and has received consulting fees, and\/or travel and research support from Metavention, Medtronic, Abbott, Novartis, Servier, Pfizer, and Boehringer-Ingelheim and serves on Advisory Board for Medtronic and Metavention.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}