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We aimed\u00a0to evaluate the incidence and outcome of PMI diagnosed using hs-cTnI, and compare it to PMI diagnosed using hs-cTnT.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We prospectively included 2455 patients at high cardiovascular risk undergoing 3111 non-cardiac surgeries, for whom hs-cTnI and hs-cTnT concentrations were measured before surgery and on postoperative days 1 and 2. PMI was defined as a composite of perioperative myocardial infarction (PMI<jats:sub>Infarct<\/jats:sub>) and perioperative myocardial injury (PMI<jats:sub>Injury<\/jats:sub>), according to the Fourth Universal Definition of Myocardial Infarction. All-cause mortality was the primary endpoint.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Using hs-cTnI, the incidence of overall PMI was 9% (95% confidence interval [CI] 8\u201310%), including PMI<jats:sub>Infarct<\/jats:sub> 2.6% (95% CI 2.0\u20133.2) and PMI<jats:sub>Injury<\/jats:sub> 6.1% (95% CI 5.3\u20136.9%), which was lower versus using hs-cTnT: overall PMI 15% (95% CI 14\u201316%), PMI<jats:sub>Infarct<\/jats:sub> 3.7% (95% CI 3.0\u20134.4) and PMI<jats:sub>Injury<\/jats:sub> 11.3% (95% CI 10.2\u201312.4%). All-cause mortality occurred in 52 (2%) patients within 30\u00a0days and 217 (9%) within 1\u00a0year. Using hs-cTnI, both PMI<jats:sub>Infarct<\/jats:sub> and PMI<jats:sub>Injury<\/jats:sub> were independent predictors of 30-day all-cause mortality (adjusted hazard ratio [aHR] 2.5 [95% CI 1.1\u20136.0], and aHR 2.8 [95% CI 1.4\u20135.5], respectively) and, 1-year all-cause mortality (aHR 2.0 [95% CI 1.2\u20133.3], and aHR 1.8 [95% CI 1.2\u20132.7], respectively). Overall, the prognostic impact of PMI diagnosed by hs-cTnI was comparable to the prognostic impact of PMI using hs-cTnT.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Using hs-cTnI, PMI is less common versus using hs-cTnT. Using hs-cTnI, both PMI<jats:sub>Infarct<\/jats:sub> and PMI<jats:sub>Injury<\/jats:sub> remain independent predictors of 30-day and 1-year mortality.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphic abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00392-021-01827-w","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T23:10:28Z","timestamp":1616713828000},"page":"1450-1463","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Incidence and outcomes of perioperative myocardial infarction\/injury diagnosed by high-sensitivity cardiac troponin I"],"prefix":"10.1007","volume":"110","author":[{"given":"Danielle M.","family":"Gualandro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Puelacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Lurati Buse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Glarner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco A.","family":"Cardozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronja","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reka","family":"Hidvegi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Strunz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bolliger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Gueckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pai C.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Liffert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketina","family":"Arslani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Prepoudis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Calderaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Hammerer-Lercher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Lampart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luzius A.","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Sch\u00e4ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kindler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Guerke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Osswald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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They do accept honorariums\/payments from industry to support research endeavours and costs to participate in meetings. Based on study questions he has originated and grants he has written; he has received grants from Abbott Diagnostics; AstraZeneca; Bayer; Boehringer Ingelheim; Bristol-Myers-Squibb; Coviden; Octapharma; Philips Healthcare; Roche Diagnostics and Stryker. Dr. Mueller has received research support\/grants from the Swiss National Science Foundation, the Swiss Heart Foundation, the Cardiovascular Research Foundation Basel, the University Hospital Basel, the University of Basel, Abbott, Beckman Coulter, BRAHMS, Ortho Clinical, Quidel, Roche, Siemens, and Sphingotec, as well as speaker\/consulting honoraria from Acon, Amgen, Astra Zeneca, Bayer, Boehringer Ingelheim, Osler, Novartis, Roche, and Sanofi. All other authors have no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The local ethics committees approved the protocol (NCT02573532\/CAPPESQ 610608), and all patients provided written consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}