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Predictors of POD in percutaneous mitral or tricuspid valve procedures are unclear.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In a prospective single-center study, patients were screened for POD using the Confusion Assessment Method on the first and second postprocedural days, and up until 7\u00a0days in patients with clinical suspicion of delirium. Associations of POD with baseline characteristics, periprocedural outcome and mid-term mortality were examined.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>One hundred and seventy-seven patients were included (median age 78\u00a0years [72\u201382], 41.8% female) and median (IQR) follow-up was 489 (293\u2013704) days. Patients developing POD (<jats:italic>n<\/jats:italic>\u2009=\u200916, 9%) did not differ in baseline and procedural characteristics but more often received postinterventional blood transfusions (37.5% vs. 9.9%, <jats:italic>p<\/jats:italic> value\u2009=\u20090.007) and suffered from infections (43.8% vs. 9.9%, <jats:italic>p<\/jats:italic> value\u2009=\u20090.001). Patients with POD showed worse survival (HR: 2.71 [1.27\u20135.78]; <jats:italic>p<\/jats:italic>\u2009=\u20090.01), with an estimated 1-year survival of 46\u2009\u00b1\u200913% compared to 80\u2009\u00b1\u20093% in patients without POD (log-rank <jats:italic>p<\/jats:italic> value 0.007). In multivariate Cox regression, POD remained a significant predictor of mid-term mortality (HR 4.75 [1.97\u201311.5]; <jats:italic>p<\/jats:italic>\u2009=\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>After percutaneous mitral or tricuspid valve repair, POD was independently associated with worse mid-term survival. Procedure- rather than patient-associated characteristics such as blood transfusions and infections emerged as important risk factors for development of POD. Considering the substantial prognostic impact of POD, further studies on its prevention are warranted to improve patient outcome.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00392-021-01886-z","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T16:32:50Z","timestamp":1622565170000},"page":"1921-1929","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Periinterventional inflammation and blood transfusions predict postprocedural delirium after percutaneous repair of mitral and tricuspid valves"],"prefix":"10.1007","volume":"110","author":[{"given":"Maria I.","family":"K\u00f6rber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakave","family":"Vimalathasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Mauri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Iliadis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens","family":"Metze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik ten","family":"Freyhaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"issue":"10","key":"1886_CR1","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1176\/appi.ajp.2018.18070893","volume":"176","author":"RP Thom","year":"2019","unstructured":"Thom RP, Levy-Carrick NC, Bui M et al (2019) Delirium. 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RP has received honorary by Abbot Cardiovascular (Abbott Park, North Chicago, US). The other authors declare that they have no relationship with industry.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. The study was approved by the local ethics committee of the University of Cologne (14-116).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Patients signed informed consent regarding publishing their data.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}