{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:18:52Z","timestamp":1771510732822,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T00:00:00Z","timestamp":1630108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s00392-021-01911-1","type":"journal-article","created":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T18:04:39Z","timestamp":1630173879000},"page":"541-547","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of HAS-BLED Score on outcome after percutaneous left atrial appendage closure: insights from the German Left Atrial Appendage Occluder Registry LAARGE"],"prefix":"10.1007","volume":"111","author":[{"given":"Jakob","family":"Ledwoch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Franke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Brachmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Lewalter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Senges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Hochadel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Zeymer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Wei\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Krapivsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst","family":"Sievert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,28]]},"reference":[{"key":"1911_CR1","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1001\/jama.2014.15192","volume":"312","author":"VY Reddy","year":"2014","unstructured":"Reddy VY, Sievert H, Halperin J, Doshi SK, Buchbinder M, Neuzil P et al (2014) Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial. JAMA 312:1988\u20131998","journal-title":"JAMA"},{"issue":"4","key":"1911_CR2","first-page":"403","volume":"2","author":"J Brachmann","year":"2019","unstructured":"Brachmann J, Lewalter T, Akin I, Sievert H, Geist V, Zeymer U et al (2019) Interventional occlusion of left atrial appendage in patients with atrial fibrillation. Acute and long-term outcome of occluder implantation in the LAARGE Registry. J Interv Card Electrophysiol 2(4):403\u2013412","journal-title":"J Interv Card Electrophysiol"},{"key":"1911_CR3","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1093\/eurheartj\/ehv730","volume":"37","author":"LV Boersma","year":"2016","unstructured":"Boersma LV, Schmidt B, Betts TR, Sievert H, Tamburino C, Teiger E et al (2016) Implant success and safety of left atrial appendage closure with the WATCHMAN device: peri-procedural outcomes from the EWOLUTION registry. Eur Heart J 37:2465\u20132474","journal-title":"Eur Heart J"},{"key":"1911_CR4","doi-asserted-by":"publisher","first-page":"e590","DOI":"10.4244\/EIJ-D-18-00344","volume":"14","author":"U Landmesser","year":"2018","unstructured":"Landmesser U, Tondo C, Camm J, Diener HC, Paul V, Schmidt B et al (2018) Left atrial appendage occlusion with the AMPLATZER Amulet device: one-year follow-up from the prospective global Amulet observational registry. EuroIntervention 14:e590\u2013e597","journal-title":"EuroIntervention"},{"key":"1911_CR5","doi-asserted-by":"publisher","first-page":"103","DOI":"10.4244\/EIJV12I1A18","volume":"12","author":"A Tzikas","year":"2016","unstructured":"Tzikas A, Holmes DR Jr, Gafoor S, Ruiz CE, Blomstrom-Lundqvist C, Diener HC et al (2016) Percutaneous left atrial appendage occlusion: the Munich consensus document on definitions, endpoints and data collection requirements for clinical studies. EuroIntervention 12:103\u2013111","journal-title":"EuroIntervention"},{"key":"1911_CR6","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1016\/j.jcin.2015.08.035","volume":"8","author":"MJ Price","year":"2015","unstructured":"Price MJ, Reddy VY, Valderrabano M, Halperin JL, Gibson DN, Gordon N et al (2015) Bleeding outcomes after left atrial appendage closure compared with long-term warfarin: a pooled, patient-level analysis of the WATCHMAN randomized trial experience. JACC Cardiovasc Interv 8:1925\u20131932","journal-title":"JACC Cardiovasc Interv"},{"key":"1911_CR7","doi-asserted-by":"publisher","first-page":"867","DOI":"10.4244\/EIJ-D-17-00493","volume":"13","author":"U Landmesser","year":"2017","unstructured":"Landmesser U, Schmidt B, Nielsen-Kudsk JE, Lam SCC, Park JW, Tarantini G et al (2017) Left atrial appendage occlusion with the AMPLATZER Amulet device: periprocedural and early clinical\/echocardiographic data from a global prospective observational study. EuroIntervention 13:867\u2013876","journal-title":"EuroIntervention"},{"key":"1911_CR8","doi-asserted-by":"publisher","first-page":"B11","DOI":"10.1016\/j.jacc.2016.09.046","volume":"68","author":"V Reddy","year":"2016","unstructured":"Reddy V, Price M, Valderrabano M, Sanchez J, Doshi S, Gordon N et al (2016) TCT-26 long-term event rates for left atrial appendage closure with WATCHMAN: PROTECT AF 5 Year and PREVAIL 3 year follow-up. J Am Coll Cardiol 68:B11","journal-title":"J Am Coll Cardiol"},{"key":"1911_CR9","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1016\/j.hrthm.2017.05.038","volume":"14","author":"LV Boersma","year":"2017","unstructured":"Boersma LV, Ince H, Kische S, Pokushalov E, Schmitz T, Schmidt B et al (2017) Efficacy and safety of left atrial appendage closure with WATCHMAN in patients with or without contraindication to oral anticoagulation: 1-year follow-up outcome data of the EWOLUTION trial. Heart Rhythm 14:1302\u20131308","journal-title":"Heart Rhythm"},{"key":"1911_CR10","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.4244\/EIJY15M01_06","volume":"11","author":"A Tzikas","year":"2016","unstructured":"Tzikas A, Shakir S, Gafoor S, Omran H, Berti S, Santoro G et al (2016) Left atrial appendage occlusion for stroke prevention in atrial fibrillation: multicentre experience with the AMPLATZER cardiac Plug. EuroIntervention 11:1170\u20131179","journal-title":"EuroIntervention"},{"key":"1911_CR11","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1093\/europace\/euaa074","volume":"22","author":"J Ledwoch","year":"2020","unstructured":"Ledwoch J, Sievert K, Boersma LVA, Bergmann MW, Ince H, Kische S et al (2020) Initial and long-term antithrombotic therapy after left atrial appendage closure with the WATCHMAN. Europace 22:1036\u20131043","journal-title":"Europace"},{"key":"1911_CR12","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1378\/chest.10-0134","volume":"138","author":"R Pisters","year":"2010","unstructured":"Pisters R, Lane DA, Nieuwlaat R, de Vos CB, Crijns HJ, Lip GY (2010) A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro heart survey. Chest 138:1093\u20131100","journal-title":"Chest"},{"key":"1911_CR13","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1212\/WNL.56.6.773","volume":"56","author":"RD Bailey","year":"2001","unstructured":"Bailey RD, Hart RG, Benavente O, Pearce LA (2001) Recurrent brain hemorrhage is more frequent than ischemic stroke after intracranial hemorrhage. Neurology 56:773\u2013777","journal-title":"Neurology"},{"key":"1911_CR14","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1212\/WNL.59.2.205","volume":"59","author":"SE Vermeer","year":"2002","unstructured":"Vermeer SE, Algra A, Franke CL, Koudstaal PJ, Rinkel GJ (2002) Long-term prognosis after recovery from primary intracerebral hemorrhage. Neurology 59:205\u2013209","journal-title":"Neurology"},{"key":"1911_CR15","doi-asserted-by":"publisher","first-page":"2614","DOI":"10.1016\/j.jacc.2015.04.025","volume":"65","author":"DR Holmes Jr","year":"2015","unstructured":"Holmes DR Jr, Doshi SK, Kar S, Price MJ, Sanchez JM, Sievert H et al (2015) Left atrial appendage closure as an alternative to warfarin for stroke prevention in atrial fibrillation: a patient-level meta-analysis. J Am Coll Cardiol 65:2614\u20132623","journal-title":"J Am Coll Cardiol"}],"container-title":["Clinical Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-021-01911-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00392-021-01911-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-021-01911-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T08:10:31Z","timestamp":1651219831000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00392-021-01911-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,28]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["1911"],"URL":"https:\/\/doi.org\/10.1007\/s00392-021-01911-1","relation":{},"ISSN":["1861-0684","1861-0692"],"issn-type":[{"value":"1861-0684","type":"print"},{"value":"1861-0692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,28]]},"assertion":[{"value":"9 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Jakob Ledwoch: none.Jennifer Franke: none.Johannes Brachmann: none.Thorsten Lewalter: Speaker honorary from St. Jude Medical\/Abbott Vascular and Boston Scientific.Ibrahim Akin: none.Jochen Senges: none.Matthias Hochadel: none.Christian Wei\u00df: none.Alexander Krapivsky: none.Horst Sievert: Study honorary, travel expenses, consulting fees from Access Closure, AGA, Angiomed, Ardian, Arstasis, Atritech, Atrium, Avinger, Bard, Boston Scientific, Bridgepoint, CardioKinetix, CardioMEMS, Coherex, Contego, CSI, EndoCross, EndoTex, Epitek, Evalve, ev3, FlowCardia, Gore, Guidant, Lumen Biomedical, HLT, Kensey Nash, Kyoto Medical, Lifetech, Lutonix, Medinol, Medtronic, NDC, NMT, OAS, Occlutech, Osprey, Ovalis, Pathway, PendraCare, Percardia, pfm Medical, Recor, Rox Medical, Sadra, Sorin, Spectranetics, SquareOne, Trireme, Trivascular, Viacor, Velocimed, Veryan.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}