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The aim of the current study was to identify non-invasive predictors for infranodal conduction delay in patients with LBBB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed consecutive patients undergoing TAVR with pre-existing or new-onset LBBB between August 2014 and August 2020. His ventricular (HV) interval measurement was performed on day 1 after TAVR. Baseline, procedural, as well as surface and intracardiac electrocardiographic parameters were included. Infranodal conduction delay was defined as HV interval\u2009&gt;\u200955\u00a0ms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 825 patients screened after TAVR, 151 patients (82\u2009\u00b1\u20096\u00a0years, 39% male) with LBBB were included. Among these, infranodal conduction delay was observed in 25%. \u0394PR (difference in PR interval after and before TAVR), PR and QRS duration after TAVR were significantly longer in the group with HV prolongation. In a multivariate analysis in patients with sinus rhythm (<jats:italic>n<\/jats:italic>\u2009=\u2009123), \u0394PR (OR per 10\u00a0ms increase: 1.52; 95%CI: 1.19\u20132.01;<jats:italic>p<\/jats:italic>\u2009=\u20090.002) was the only independent factor associated with infranodal conduction delay. A change in PR interval by 20\u00a0ms yielded a specificity of 83% and a sensitivity of 46%, with a negative predictive value of 84% and a positive predictive value of 45% to predict HV prolongation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Simple analysis of surface ECG and a calculated \u0394PR\u2009&lt;\u200920\u00a0ms can be used as predictor for the absence of infranodal conduction delay in post-TAVR patients with LBBB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Graphical abstract<\/jats:title><\/jats:sec>","DOI":"10.1007\/s00392-021-01924-w","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:25:58Z","timestamp":1630023958000},"page":"1967-1976","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Non-invasive predictors for infranodal conduction delay in patients with left bundle branch block after TAVR"],"prefix":"10.1007","volume":"110","author":[{"given":"Chlo\u00e9","family":"Auberson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9751-0557","authenticated-orcid":false,"given":"Patrick","family":"Badertscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8364-3279","authenticated-orcid":false,"given":"Antonio","family":"Madaffari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriton","family":"Malushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Bourquin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8974-9541","authenticated-orcid":false,"given":"Florian","family":"Spies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8134-2421","authenticated-orcid":false,"given":"Stefanie","family":"Aeschbacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Fahrni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1290-5491","authenticated-orcid":false,"given":"Raban","family":"Jeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9240-6731","authenticated-orcid":false,"given":"Stefan","family":"Osswald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8428-7050","authenticated-orcid":false,"given":"Christian","family":"Sticherling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7122-021X","authenticated-orcid":false,"given":"Sven","family":"Knecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2937-3711","authenticated-orcid":false,"given":"Michael","family":"K\u00fchne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,26]]},"reference":[{"key":"1924_CR1","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1016\/j.jacc.2019.07.014","volume":"74","author":"J Rod\u00e9s-Cabau","year":"2019","unstructured":"Rod\u00e9s-Cabau J, Ellenbogen KA, Krahn AD et al (2019) Management of conduction disturbances associated with transcatheter aortic valve replacement: JACC Scientific Expert Panel. 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Michael K\u00fchne: reports grants from the Swiss National Science Foundation, Swiss Heart Foundation, Bayer, Pfizer BMS, Boston Scientific, personal fees from Bayer, B\u00f6hringer Ingelheim, Pfizer BMS, Daiichi Sankyo, Medtronic, Biotronik, Boston Scientific, Johnson & Johnson all outside the submitted work. Sven Knecht: reports grant from the Freiwillige Akademische Gesellschaft (FAG) Basel and the Stiftung Kardiovaskul\u00e4re Forschung. Others: none.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"This study was ethics approved and performed in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All patients provided written informed consent to participate in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors read and consented to the final manuscript version for publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}