{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:09:51Z","timestamp":1792192191049,"version":"4.4.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum des Saarlandes und Medizinische Fakult\u00e4t der Universit\u00e4t des Saarlandes"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Right ventricular pacing (RVP) may cause electrical and mechanical desynchrony leading to impaired left ventricular ejection fraction (LVEF). We investigated the outcomes of RVP with His bundle pacing (HBP) and left bundle branch pacing (LBBP) for patients requiring a de novo permanent pacemaker (PPM) for bradyarrhythmia.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods and results<\/jats:title>\n                <jats:p>Systematic review of randomized clinical trials and observational studies comparing HBP or LBP with RVP for de novo PPM implantation between 01 January 2013 and 17 November 2020 was performed. Random and fixed effects meta-analyses of the effect of pacing technology on outcomes were performed. Study outcomes included all-cause mortality, heart failure hospitalization (HFH), LVEF, QRS duration, lead revision, atrial fibrillation, procedure parameters, and pacing metrics. Overall, 9 studies were included (6 observational, 3 randomised). HBP compared with RVP was associated with decreased HFH (risk ratio [RR] 0.68, 95% confidence interval [CI] 0.49\u20130.94), preservation of LVEF (mean difference [MD] 0.81, 95% CI \u2212\u00a01.23 to 2.85 vs. \u2212\u00a05.72, 95% CI \u2212\u00a07.64 to -3.79), increased procedure duration (MD 15.17\u00a0min, 95% CI 11.30\u201319.04), and increased lead revisions (RR 5.83, 95% CI 2.17\u201315.70, <jats:italic>p<\/jats:italic>\u2009=\u20090.0005). LBBP compared with RVP was associated with shorter paced QRS durations (MD 5.6\u00a0ms, 95% CI \u2212\u00a06.4 to 17.6) vs. (51.0\u00a0ms, 95% CI 39.2\u201362.9) and increased procedure duration (MD 37.78\u00a0min, 95% CI 20.04\u201355.51).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Of the limited studies published, this meta-analysis found that HBP and LBBP were superior to RVP in maintaining physiological ventricular activation as an initial pacing strategy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00392-021-01927-7","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T07:03:20Z","timestamp":1629356600000},"page":"1198-1209","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Outcomes of conduction system pacing compared to right ventricular pacing as a primary strategy for treating bradyarrhythmia: systematic review and meta-analysis"],"prefix":"10.1007","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0847-1694","authenticated-orcid":false,"given":"Amr","family":"Abdin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleman","family":"Aktaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davor","family":"Vukadinovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Arbelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harran","family":"Burri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Glikson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Munyombwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Cosedis","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ukena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Vernooy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris P.","family":"Gale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"key":"1927_CR1","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1093\/eurheartj\/eht150","volume":"34","author":"M Brignole","year":"2013","unstructured":"Brignole M, Auricchio A, Baron-Esquivias G, Bordachar P, Boriani G, Breithardt OA et al (2013) ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: The Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). Eur Heart J 34:2281\u20132329","journal-title":"Eur Heart J"},{"key":"1927_CR2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jelectrocard.2019.08.016","volume":"57","author":"A Abdin","year":"2019","unstructured":"Abdin A, Yalin K, Zink MD, Napp A, Gramlich M, Marx N, Schuett K (2019) Incidence and predictors of pacemaker induced cardiomyopathy: a single-center experience. J Electrocardiol 57:31\u201334","journal-title":"J Electrocardiol"},{"issue":"8","key":"1927_CR3","doi-asserted-by":"publisher","first-page":"e010972","DOI":"10.1161\/JAHA.118.010972","volume":"19","author":"AJM Lewis","year":"2019","unstructured":"Lewis AJM, Foley P, Whinnett Z, Keene D, Chandrasekaran B (2019) His bundle pacing: a new strategy for physiological ventricular activation. 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MG is supported by grants from Biotronik, Pfizer and Philips and received honoraria for Boston Scientific. JC Nielsen is supported by grants from the Novo Nordisk Foundation (NNF16OC0018658 and NNF17OC0029148). CU has received honoraria for lectures and scientific advice from Bayer, Boehringer-Ingelheim, Medtronic, Pfizer, ReCor Medical. KV is supported by grants from the Abbott and Medtronic and received honoraria for lectures and scientific advice from Abbott, Boston Scientific and Medtronic. CPG is supported by grants from the Abbott and BMS and received honoraria for lectures and scientific advice from Amgen and AstraZeneca. AA, SA, DV, EA, CM and TM: none declared.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}