{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:34:44Z","timestamp":1787160884142,"version":"build-2736575974"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T00:00:00Z","timestamp":1632182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Freiburg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The effect of valve type on outcomes in transfemoral transcatheter aortic valve replacement (TF-TAVR) has recently been subject of debate. We investigate outcomes of patients treated with balloon-expanding (BE) vs. self-expanding (SE) valves in in a cohort of all these procedures performed in Germany in 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      All patients receiving TF-TAVR with either BE (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20099,882) or SE (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20097,413) valves in Germany in 2018 were identified. In-hospital outcomes were analyzed for the endpoints in-hospital mortality, major bleeding, stroke, acute kidney injury, postoperative delirium, permanent pacemaker implantation, mechanical ventilation\u2009&gt;\u200948\u00a0h, length of hospital stay, and reimbursement. Since patients were not randomized to the two treatment options, logistic or linear regression models were used with 22 baseline patient characteristics and center-specific variables as potential confounders. As a sensitivity analysis, the same confounding factors were taken into account using the propensity score methods (inverse probability of treatment weighting).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline characteristics differed substantially, with higher EuroSCORE (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and rate of female sex (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in SE treated patients. After risk adjustment, no marked differences in outcomes were found for in-hospital mortality [risk adjusted odds ratio (aOR) for SE instead of BE 0.94 (96% CI 0.76;1.17),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.617] major bleeding [aOR 0.91 (0.73;1.14),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.400], stroke [aOR 1.13 (0.88;1.46),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.347], acute kidney injury [OR 0.97 (0.85;1.10),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.621], postoperative delirium [aOR 1.09 (0.96;1.24),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.184], mechanical ventilation\u2009&gt;\u200948\u00a0h [aOR 0.98 (0.77;1.25),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.893], length of hospital stay (risk adjusted difference in days of hospitalization (SE instead of BE): \u2212\u00a00.05 [\u2212\u00a00.34;0.25],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.762) and reimbursement [risk adjusted difference in reimbursement (SE instead of BE): \u2212\u00a0\u20ac72 (\u2212\u00a0\u20ac291;\u20ac147),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.519)] There is, however, an increased risk of PPI for SE valves (aOR 1.27 [1.15;1.41],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Similar results were found after application of propensity score adjustment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We find broadly equivalent outcomes in contemporary TF-TAVR procedures, regardless of the valve type used. Incidence of major complications is very low for both types of valve.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-021-01928-6","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T09:16:40Z","timestamp":1632215800000},"page":"1977-1982","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["In-hospital outcomes of self-expanding and balloon-expandable transcatheter heart valves in Germany"],"prefix":"10.1007","volume":"110","author":[{"given":"Peter","family":"Stachon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Hehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Heidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Oettinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Zehender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Bode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"von zur M\u00fchlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-6945","authenticated-orcid":false,"given":"Klaus","family":"Kaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,21]]},"reference":[{"issue":"24","key":"1928_CR1","doi-asserted-by":"publisher","first-page":"3006","DOI":"10.1161\/01.CIR.0000047200.36165.B8","volume":"106","author":"A Cribier","year":"2002","unstructured":"Cribier A, Eltchaninoff H, Bash A et al (2002) Percutaneous transcatheter implantation of an aortic valve prosthesis for calcific aortic stenosis: first human case description. 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