{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T01:17:49Z","timestamp":1793582269861,"version":"4.5.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Bonn"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Clinical data regarding the association between the left atrial function index (LAFI) and outcome in patients undergoing transcatheter aortic valve replacement (TAVR) are limited.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>We aimed to investigate the association between the left atrial function index (LAFI) and outcome in patients undergoing TAVR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this retrospective multicenter study, we assessed baseline LAFI in 733 patients undergoing TAVR for severe aortic stenosis in two German high-volume centers between 2008 and 2019. Based on receiver operating characteristic curves, patients were stratified according to their baseline LAFI into two groups (LAFI\u2009\u2264\u200913.5 vs. LAFI\u2009&gt;\u200913.5) and assessed for post-procedural outcome. The primary endpoint of our study was the 1-year all-cause mortality.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Patients with a LAFI\u2009\u2264\u200913.5 had significantly more often atrial fibrillation (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), lower LVEF (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and higher levels of NT-proBNP (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). After TAVR, a significant improvement in the LAFI as compared to baseline was observed at 12\u00a0months after the procedure (28.4 vs. 32.9; <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Compared to patients with a LAFI\u2009&gt;\u200913.5, those with a LAFI\u2009\u2264\u200913.5 showed significantly higher rate of 1-year mortality (7.9% vs. 4.0%; <jats:italic>p<\/jats:italic>\u2009=\u20090.03). A lower LAFI has been identified as independent predictor of mortality in multivariate analysis (HR (95% CI) 2.0 (1.1\u20133.9); <jats:italic>p<\/jats:italic>\u2009=\u20090.03).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>A reduced LAFI is associated with adverse outcome and an independent predictor of mortality in TAVR patients. TAVR improves LAFI within 12\u00a0months after the procedure.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                <jats:p>Left Atrial Function Index (LAFI) in Patients undergoing Transcatheter Aortic Valve Implantation. <jats:bold>A<\/jats:bold> Kaplan\u2013Meier survival analysis of 1-year all-cause mortality in patients with LAFI\u2009\u2264\u200913.5 compared with patients with LAFI\u2009&gt;\u200913.5. Comparing rates of 1-year all-cause mortality between the different LAFI groups, we found a significant association between left atrial function and mortality. <jats:italic>LAFI<\/jats:italic> Left atrial function index. <jats:bold>B<\/jats:bold> Comparison of the mean LAFI before and after TAVR. After long-term follow-up the LAFI improved significantly. <jats:italic>LAFI<\/jats:italic> Left atrial function index; <jats:italic>FU<\/jats:italic> follow-up. <jats:bold>C<\/jats:bold> Assessment of the left atrial function index using the pre-procedural transthoracic echocardiography. <jats:bold>A<\/jats:bold> Measurement of the minimal left atrial volume (LAEDV). <jats:bold>B<\/jats:bold> Assessment of the maximal left atrial volume (LAESV).<\/jats:p>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00392-022-02010-5","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T12:06:00Z","timestamp":1648037160000},"page":"944-954","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Left atrial function index (LAFI) and outcome in patients undergoing transcatheter aortic valve replacement"],"prefix":"10.1007","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5724-9814","authenticated-orcid":false,"given":"Jasmin","family":"Shamekhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Quynh Anh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Sigel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Piayda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Zeus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baravan","family":"Al-Kassou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal","family":"Wilde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Kelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Nickenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Veulemans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Sedaghat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"2010_CR1","doi-asserted-by":"crossref","first-page":"E341","DOI":"10.1002\/ccd.28542","volume":"96","author":"R De Rosa","year":"2020","unstructured":"De Rosa R, Murray MI, Schranz D et al (2020) Short-term decrease of left atrial size predicts clinical outcome in patients with severe aortic stenosis undergoing TAVR. 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Tobias Zeus and Verena Veulemans have received consulting fees, travel expenses, or study honoraria from Medtronic and Edwards Lifesciences. The other authors report no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}