{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:21:03Z","timestamp":1790716863313,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005722","name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005722","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The study objective was to characterize different groups of low-flow low-gradient (LFLG) aortic stenosis (AS) and determine short-term outcomes and long-term mortality according to Valve Academic Research Consortium-3 (VARC-3) endpoint definitions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Characteristics and outcomes of patients with LFLG AS undergoing transcatheter aortic valve implantation (TAVI) are poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      All patients undergoing TAVI at our center between 2013 and 2019 were screened. Patients were divided into three groups according to mean pressure gradient (dPmean), ejection fraction (LVEF), and stroke volume index (SVi): high gradient (HG) AS (dPmean\u2009\u2265\u200940\u00a0mmHg), classical LFLG (cLFLG) AS (dPmean\u2009&lt;\u200940\u00a0mmHg, LVEF\u2009&lt;\u200950%), and paradoxical LFLG (pLFLG) AS (dPmean\u2009&lt;\u200940\u00a0mmHg, LVEF\u2009\u2265\u200950%, SVi\u2009\u2264\u200935\u00a0ml\/m\n                      <jats:sup>2<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 1776 patients (956 HG, 447 cLFLG, and 373 pLFLG patients). Most baseline characteristics differed significantly. Median Society of Thoracic Surgeons (STS) score was highest in cLFLG, followed by pLFLG and HG patients (5.0, 3.9 and 3.0, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Compared to HG patients, odds ratios for the short-term VARC-3 composite endpoints, technical failure (cLFLG, 0.76 [95% confidence interval, 0.40\u20131.36], pLFLG, 1.37 [0.79\u20132.31]) and device failure (cLFLG, 1.06 [0.74\u20131.49], pLFLG, 0.97 [0.66\u20131.41]) were similar, without relevant differences within LFLG patients. NYHA classes improved equally in all groups. Compared to HG, LFLG patients had a higher 3-year all-cause mortality (STS score-adjusted hazard ratios, cLFLG 2.16 [1.77\u20132.64], pLFLG 1.53 [1.22\u2013193]), as well as cardiovascular mortality (cLFLG, 2.88 [2.15\u20133.84], pLFLG, 2.08 [1.50\u20132.87]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While 3-year mortality remains high after TAVI in LFLG compared to HG patients, symptoms improve in all subsets after TAVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-022-02011-4","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T12:06:05Z","timestamp":1648037165000},"page":"1325-1335","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["TAVI in patients with low-flow low-gradient aortic stenosis\u2013short-term and long-term outcomes"],"prefix":"10.1007","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8807-7365","authenticated-orcid":false,"given":"Julius","family":"Steffen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolas","family":"Rei\u00dfig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Andreae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Haum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Theiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Orban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Rizas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Sadoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"N\u00e4bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Peterss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Hausleiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Massberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8768-1184","authenticated-orcid":false,"given":"Simon","family":"Deseive","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"2011_CR1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab395","author":"A Vahanian","year":"2021","unstructured":"Vahanian A, Beyersdorf F, Praz F, Milojevic M, Baldus S, Bauersachs J, Capodanno D, Conradi L, De Bonis M, De Paulis R, Delgado V, Freemantle N, Gilard M, Haugaa KH, Jeppsson A, J\u00fcni P, Pierard L, Prendergast BD, S\u00e1daba JR, Tribouilloy C, Wojakowski W, Neumann F-J, Myers P, Abdelhamid M, Achenbach S, Asteggiano R, Barili F, Borger MA, Carrel T, Collet J-P, Foldager D, Habib G, Hassager C, Irs A, Iung B, Jahangiri M, Katus HA, Koskinas KC, Massberg S, Mueller CE, Nielsen JC, Pibarot P, Rakisheva A, Roffi M, Rubboli A, Shlyakhto E, Siepe M, Sitges M, Sondergaard L, Sousa-Uva M, Tarantini G, Zamorano JL, Praz F, Milojevic M, Baldus S, Bauersachs J, Capodanno D, Conradi L, De Bonis M, De Paulis R, Delgado V, Freemantle N, Gilard M, Haugaa KH, Jeppsson A, J\u00fcni P, Pierard L, Prendergast BD, S\u00e1daba JR, Tribouilloy C, Wojakowski W (2021) 2021 ESC\/EACTS guidelines for the management of valvular heart disease. Eur Heart J. https:\/\/doi.org\/10.1093\/eurheartj\/ehab395","journal-title":"Eur Heart J"},{"issue":"18","key":"2011_CR2","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","volume":"380","author":"JJ Popma","year":"2019","unstructured":"Popma JJ, Deeb GM, Yakubov SJ, Mumtaz M, Gada H, O\u2019Hair D, Bajwa T, Heiser JC, Merhi W, Kleiman NS, Askew J, Sorajja P, Rovin J, Chetcuti SJ, Adams DH, Teirstein PS, Zorn GL 3rd, Forrest JK, Tchetche D, Resar J, Walton A, Piazza N, Ramlawi B, Robinson N, Petrossian G, Gleason TG, Oh JK, Boulware MJ, Qiao H, Mugglin AS, Reardon MJ, Evolut Low Risk Trial I (2019) Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients. N Engl J Med 380(18):1706\u20131715. https:\/\/doi.org\/10.1056\/NEJMoa1816885","journal-title":"N Engl J Med"},{"issue":"18","key":"2011_CR3","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","volume":"380","author":"MJ Mack","year":"2019","unstructured":"Mack MJ, Leon MB, Thourani VH, Makkar R, Kodali SK, Russo M, Kapadia SR, Malaisrie SC, Cohen DJ, Pibarot P, Leipsic J, Hahn RT, Blanke P, Williams MR, McCabe JM, Brown DL, Babaliaros V, Goldman S, Szeto WY, Genereux P, Pershad A, Pocock SJ, Alu MC, Webb JG, Smith CR, Investigators P (2019) Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients. N Engl J Med 380(18):1695\u20131705. https:\/\/doi.org\/10.1056\/NEJMoa1814052","journal-title":"N Engl J Med"},{"issue":"3","key":"2011_CR4","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1093\/ehjci\/jew335","volume":"18","author":"HC Baumgartner","year":"2017","unstructured":"Baumgartner HC, Hung JC-C, Bermejo J, Chambers JB, Edvardsen T, Goldstein S, Lancellotti P, LeFevre M, Miller F Jr, Otto CM (2017) Recommendations on the echocardiographic assessment of aortic valve stenosis: a focused update from the European association of cardiovascular imaging and the American society of echocardiography. Eur Heart J Cardiovasc Imaging 18(3):254\u2013275. https:\/\/doi.org\/10.1093\/ehjci\/jew335","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"34","key":"2011_CR5","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1093\/eurheartj\/ehw096","volume":"37","author":"M-A Clavel","year":"2016","unstructured":"Clavel M-A, Magne J, Pibarot P (2016) Low-gradient aortic stenosis. Eur Heart J 37(34):2645\u20132657. https:\/\/doi.org\/10.1093\/eurheartj\/ehw096","journal-title":"Eur Heart J"},{"issue":"22","key":"2011_CR6","doi-asserted-by":"publisher","first-page":"2856","DOI":"10.1161\/CIRCULATIONAHA.106.668681","volume":"115","author":"Z Hachicha","year":"2007","unstructured":"Hachicha Z, Dumesnil JG, Bogaty P, Pibarot P (2007) Paradoxical low-flow, low-gradient severe aortic stenosis despite preserved ejection fraction is associated with higher afterload and reduced survival. Circulation 115(22):2856\u20132864. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.106.668681","journal-title":"Circulation"},{"issue":"2","key":"2011_CR7","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jcmg.2017.01.002","volume":"10","author":"M-A Clavel","year":"2017","unstructured":"Clavel M-A, Burwash IG, Pibarot P (2017) Cardiac imaging for assessing low-gradient severe aortic stenosis. JACC: Cardiovascular Imaging 10(2):185\u2013202. https:\/\/doi.org\/10.1016\/j.jcmg.2017.01.002","journal-title":"JACC: Cardiovascular Imaging"},{"key":"2011_CR8","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.119.008792","author":"E Salaun","year":"2020","unstructured":"Salaun E, Clavel M-A, Hahn RT, Jaber WA, Asch FM, Rodriguez L, Weissman NJ, Gertz ZM, Herrmann HC, Dahou A, Annabi M-S, Toubal O, Bernier M, Beaudoin J, Leipsic J, Blanke P, Ridard C, Ong G, Rod\u00e9s-Cabau J, Webb JG, Zhang Y, Alu MC, Douglas PS, Makkar R, Miller DC, Lindman BR, Thourani VH, Leon MB, Pibarot P (2020) Outcome of flow-gradient patterns of aortic stenosis after aortic valve replacement. Circ: Cardiovascular Interv. https:\/\/doi.org\/10.1161\/circinterventions.119.008792","journal-title":"Circ: Cardiovascular Interv"},{"issue":"23","key":"2011_CR9","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1161\/circulationaha.112.001290","volume":"127","author":"HC Herrmann","year":"2013","unstructured":"Herrmann HC, Pibarot P, Hueter I, Gertz ZM, Stewart WJ, Kapadia S, Tuzcu EM, Babaliaros V, Thourani V, Szeto WY, Bavaria JE, Kodali S, Hahn RT, Williams M, Miller DC, Douglas PS, Leon MB (2013) Predictors of mortality and outcomes of therapy in low-flow severe aortic stenosis. Circulation 127(23):2316\u20132326. https:\/\/doi.org\/10.1161\/circulationaha.112.001290","journal-title":"Circulation"},{"issue":"8","key":"2011_CR10","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.jcin.2019.01.233","volume":"12","author":"U Fischer-Rasokat","year":"2019","unstructured":"Fischer-Rasokat U, Renker M, Liebetrau C, van Linden A, Arsalan M, Weferling M, Rolf A, Doss M, Mollmann H, Walther T, Hamm CW, Kim WK (2019) 1-year survival after TAVR of patients with low-flow, low-gradient and high-gradient aortic valve stenosis in matched study populations. JACC Cardiovasc Interv 12(8):752\u2013763. https:\/\/doi.org\/10.1016\/j.jcin.2019.01.233","journal-title":"JACC Cardiovasc Interv"},{"issue":"19","key":"2011_CR11","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1093\/eurheartj\/ehaa799","volume":"42","author":"P G\u00e9n\u00e9reux","year":"2021","unstructured":"G\u00e9n\u00e9reux P, Piazza N, Alu MC, Nazif T, Hahn RT, Pibarot P, Bax JJ, Leipsic JA, Blanke P, Blackstone EH, Finn MT, Kapadia S, Linke A, Mack MJ, Makkar R, Mehran R, Popma JJ, Reardon M, Rodes-Cabau J, Van Mieghem NM, Webb JG, Cohen DJ, Leon MB (2021) Valve academic research consortium 3: updated endpoint definitions for aortic valve clinical research. Eur Heart J 42(19):1825\u20131857. https:\/\/doi.org\/10.1093\/eurheartj\/ehaa799","journal-title":"Eur Heart J"},{"key":"2011_CR12","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.ijcard.2017.03.003","volume":"244","author":"D Jochheim","year":"2017","unstructured":"Jochheim D, Zadrozny M, Ricard I, Sadry TM, Theiss H, Baquet M, Schwarz F, Bauer A, Khandoga A, Sadoni S, Pichlmaier M, Hausleiter J, Hagl C, Massberg S, Mehilli J (2017) Predictors of cerebrovascular events at mid-term after transcatheter aortic valve implantation\u2014results from EVERY-TAVI registry. Int J Cardiol 244:106\u2013111. https:\/\/doi.org\/10.1016\/j.ijcard.2017.03.003","journal-title":"Int J Cardiol"},{"issue":"3","key":"2011_CR13","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1093\/eurheartj\/ehx419","volume":"39","author":"M Valgimigli","year":"2017","unstructured":"Valgimigli M, Bueno H, Byrne RA, Collet JP, Costa F, Jeppsson A, Juni P, Kastrati A, Kolh P, Mauri L, Montalescot G, Neumann FJ, Petricevic M, Roffi M, Steg PG, Windecker S, Zamorano JL, Levine GN, Guidelines ESCCfP, Societies ESCNC (2018) (2017) 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: the task force for dual antiplatelet therapy in coronary artery disease of the European society of cardiology (ESC) and of the European association for cardio-thoracic surgery (EACTS). Eur Heart J 39(3):213\u2013260. https:\/\/doi.org\/10.1093\/eurheartj\/ehx419","journal-title":"Eur Heart J"},{"issue":"23","key":"2011_CR14","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1161\/circulationaha.110.009449","volume":"123","author":"R Mehran","year":"2011","unstructured":"Mehran R, Rao SV, Bhatt DL, Gibson CM, Caixeta A, Eikelboom J, Kaul S, Wiviott SD, Menon V, Nikolsky E, Serebruany V, Valgimigli M, Vranckx P, Taggart D, Sabik JF, Cutlip DE, Krucoff MW, Ohman EM, Steg PG, White H (2011) Standardized bleeding definitions for cardiovascular clinical trials. Circulation 123(23):2736\u20132747. https:\/\/doi.org\/10.1161\/circulationaha.110.009449","journal-title":"Circulation"},{"issue":"3","key":"2011_CR15","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.jcmg.2015.01.008","volume":"8","author":"P Pibarot","year":"2015","unstructured":"Pibarot P, Hahn RT, Weissman NJ, Monaghan MJ (2015) Assessment of paravalvular regurgitation following TAVR: a proposal of unifying grading scheme. JACC Cardiovasc Imaging 8(3):340\u2013360. https:\/\/doi.org\/10.1016\/j.jcmg.2015.01.008","journal-title":"JACC Cardiovasc Imaging"},{"issue":"9","key":"2011_CR16","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1038\/bmt.2009.359","volume":"45","author":"L Scrucca","year":"2010","unstructured":"Scrucca L, Santucci A, Aversa F (2010) Regression modeling of competing risk using R: an in depth guide for clinicians. Bone Marrow Transpl 45(9):1388\u20131395. https:\/\/doi.org\/10.1038\/bmt.2009.359","journal-title":"Bone Marrow Transpl"},{"issue":"3","key":"2011_CR17","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s00392-020-01752-4","volume":"110","author":"N Wilde","year":"2021","unstructured":"Wilde N, Sugiura A, Sedaghat A, Becher MU, Kelm M, Baldus S, Nickenig G, Veulemans V, Tiyerili V (2021) Risk of mortality following transcatheter aortic valve replacement for low-flow low-gradient aortic stenosis. Clin Res Cardiol 110(3):391\u2013398. https:\/\/doi.org\/10.1007\/s00392-020-01752-4","journal-title":"Clin Res Cardiol"},{"issue":"7","key":"2011_CR18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008792","volume":"13","author":"E Salaun","year":"2020","unstructured":"Salaun E, Clavel MA, Hahn RT, Jaber WA, Asch FM, Rodriguez L, Weissman NJ, Gertz ZM, Herrmann HC, Dahou A, Annabi MS, Toubal O, Bernier M, Beaudoin J, Leipsic J, Blanke P, Ridard C, Ong G, Rodes-Cabau J, Webb JG, Zhang Y, Alu MC, Douglas PS, Makkar R, Miller DC, Lindman BR, Thourani VH, Leon MB, Pibarot P (2020) Outcome of flow-gradient patterns of aortic stenosis after aortic valve replacement: an analysis of the PARTNER 2 trial and registry. Circ Cardiovasc Interv 13(7):e008792. https:\/\/doi.org\/10.1161\/CIRCINTERVENTIONS.119.008792","journal-title":"Circ Cardiovasc Interv"},{"issue":"9","key":"2011_CR19","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1093\/ehjci\/jeaa106","volume":"22","author":"MP Winter","year":"2021","unstructured":"Winter MP, Bartko PE, Krickl A, Gatterer C, Dona C, Nitsche C, Koschutnik M, Spinka G, Siller-Matula JM, Lang IM, Mascherbauer J, Hengstenberg C, Goliasch G (2021) Adaptive development of concomitant secondary mitral and tricuspid regurgitation after transcatheter aortic valve replacement. Eur Heart J Cardiovasc Imaging 22(9):1045\u20131053. https:\/\/doi.org\/10.1093\/ehjci\/jeaa106","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"3","key":"2011_CR20","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.amjcard.2019.05.006","volume":"124","author":"M Osman","year":"2019","unstructured":"Osman M, Ghaffar YA, Foster T, Osman K, Alqahtani F, Shah K, Kheiri B, Alkhouli M (2019) Meta-analysis of outcomes of transcatheter aortic valve implantation among patients with low gradient severe aortic stenosis. Am J Cardiol 124(3):423\u2013429. https:\/\/doi.org\/10.1016\/j.amjcard.2019.05.006","journal-title":"Am J Cardiol"},{"key":"2011_CR21","unstructured":"Global health data exchange GHDx (2021) Institute for health metrics and evaluation. http:\/\/ghdx.healthdata.org\/gbd-results-tool. Accessed 14.09.2021"},{"issue":"21","key":"2011_CR22","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1093\/eurheartj\/ehy123","volume":"39","author":"D Rusinaru","year":"2018","unstructured":"Rusinaru D, Bohbot Y, Ringle A, Mar\u00e9chaux S, Diouf M, Tribouilloy C (2018) Impact of low stroke volume on mortality in patients with severe aortic stenosis and preserved left ventricular ejection fraction. Eur Heart J 39(21):1992\u20131999. https:\/\/doi.org\/10.1093\/eurheartj\/ehy123","journal-title":"Eur Heart J"},{"key":"2011_CR23","doi-asserted-by":"publisher","DOI":"10.1161\/circinterventions.120.010042","author":"W Mosleh","year":"2021","unstructured":"Mosleh W, Amer MR, Ding Y, Megaly M, Mather JF, McMahon S, Pershad A, McKay RG, Arora B (2021) Benefit of transcatheter aortic valve replacement in patients with paradoxical low-flow low-gradient versus high-gradient aortic stenosis and preserved left ventricular function. Circ Cardiovascular Interv. https:\/\/doi.org\/10.1161\/circinterventions.120.010042","journal-title":"Circ Cardiovascular Interv"},{"issue":"13","key":"2011_CR24","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1016\/j.jacc.2019.01.034","volume":"73","author":"MF Eleid","year":"2019","unstructured":"Eleid MF, Padang R, Al-Hijji M, Pislaru SV, Greason KL, Maltais S, Pibarot P, Pellikka PA, Sandhu GS, Rihal CS, Nishimura RA, Borlaug BA (2019) Hemodynamic response in low-flow low-gradient aortic stenosis with preserved ejection fraction after TAVR. J Am Coll Cardiol 73(13):1731\u20131732. https:\/\/doi.org\/10.1016\/j.jacc.2019.01.034","journal-title":"J Am Coll Cardiol"},{"key":"2011_CR25","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.120.017870","author":"MS Annabi","year":"2020","unstructured":"Annabi MS, C\u00f4t\u00e9 N, Dahou A, Bartko PE, Bergler-Klein J, Burwash IG, Orwat S, Baumgartner H, Mascherbauer J, Mundigler G, Fukui M, Cavalcante J, Ribeiro HB, Rod\u00e8s-Cabau J, Clavel MA, Pibarot P (2020) Comparison of early surgical or transcatheter aortic valve replacement versus conservative management in low-flow, low-gradient aortic stenosis using inverse probability of treatment weighting: results from the TOPAS prospective observational cohort study. J Am Heart Assoc. https:\/\/doi.org\/10.1161\/jaha.120.017870","journal-title":"J Am Heart Assoc"}],"container-title":["Clinical Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-022-02011-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00392-022-02011-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-022-02011-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T17:07:34Z","timestamp":1669136854000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00392-022-02011-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,23]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["2011"],"URL":"https:\/\/doi.org\/10.1007\/s00392-022-02011-4","relation":{},"ISSN":["1861-0684","1861-0692"],"issn-type":[{"value":"1861-0684","type":"print"},{"value":"1861-0692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,23]]},"assertion":[{"value":"5 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"JS received speaker honoraria from AstraZeneca. DB received speaker honoraria from Abbott Vascular. MO received speaker honoraria and travel compensations from Abbott Medical, AstraZeneca, Abiomed, Bayer vital, BIOTRONIK, Bristol-Myers Squibb, CytoSorbents, Daiichi Sankyo Germany, Edwards Lifesciences Services, and Sedana Medical. JH received research support Abbott Vascular and Edwards Lifesciences. SD received speaker honoraria from AstraZeneca. All other authors report to have no conflicts of interests to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study has been approved by the local ethics committee and has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}