{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:01:26Z","timestamp":1792803686725,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Johann Wolfgang Goethe-Universit\u00e4t, Frankfurt am Main"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Cerebral oxygen saturation (ScO<jats:sub>2<\/jats:sub>) can be measured non-invasively by near-infrared spectroscopy (NIRS) and correlates with cerebral perfusion. We investigated cerebral saturation during transfemoral transcatheter aortic valve implantation (TAVI) and its impact on outcome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods and results<\/jats:title>\n                <jats:p>Cerebral oxygenation was measured continuously by NIRS in 173 analgo-sedated patients during transfemoral TAVI (female 47%, mean age 81\u00a0years) with self-expanding (39%) and balloon-expanding valves (61%). We investigated the periprocedural dynamics of cerebral oxygenation. Mean ScO<jats:sub>2<\/jats:sub> at baseline without oxygen supply was 60%. During rapid ventricular pacing, ScO<jats:sub>2<\/jats:sub> dropped significantly (before 64% vs. after 55%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). ScO<jats:sub>2<\/jats:sub> at baseline correlated positively with baseline left-ventricular ejection fraction (0.230, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.006) and hemoglobin (0.327, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and inversely with EuroSCORE-II (\u2009\u2212\u20090.285, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and length of in-hospital stay (\u2009\u2212\u20090.229, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Patients with ScO2\u2009&lt;\u200956% despite oxygen supply at baseline had impaired 1\u00a0year survival (log-rank test <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and prolonged in-hospital stay (<jats:italic>p<\/jats:italic>\u2009=\u20090.03). Furthermore, baseline ScO<jats:sub>2<\/jats:sub> was found to be a predictor for 1\u00a0year survival independent of age and sex (multivariable adjusted Cox regression, <jats:italic>p<\/jats:italic>\u2009=\u20090.020, hazard ratio (HR 0.94, 95% CI 0.90\u20130.99) and independent of overall perioperative risk estimated by EuroSCORE-II and hemoglobin (<jats:italic>p<\/jats:italic>\u2009=\u20090.03, HR 0.95, 95% CI 0.91\u20130.99).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Low baseline ScO<jats:sub>2<\/jats:sub> not responding to oxygen supply might act as a surrogate for impaired cardiopulmonary function and is associated with worse 1\u00a0year survival and prolonged in-hospital stay after transfemoral TAVI. ScO<jats:sub>2<\/jats:sub> monitoring is an easy to implement diagnostic tool to screen patients at risk with a potential preserved recovery and worse outcome after TAVI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00392-022-02019-w","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T03:57:48Z","timestamp":1651636668000},"page":"955-965","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cerebral oxygen saturation as outcome predictor after transfemoral transcatheter aortic valve implantation"],"prefix":"10.1007","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4743-6920","authenticated-orcid":false,"given":"Philipp C.","family":"Seppelt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Mas-Peiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Van Linden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Iken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zacharowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Walther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Fichtlscherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariuca","family":"Vasa-Nicotera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,4]]},"reference":[{"key":"2019_CR1","doi-asserted-by":"publisher","DOI":"10.1093\/EJCTS\/EZAB389","author":"A Vahanian","year":"2021","unstructured":"Vahanian A, Beyersdorf F, Praz F et al (2021) 2021 ESC\/EACTS guidelines for the management of valvular heart disease. 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