{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:18:13Z","timestamp":1792783093514,"version":"4.5.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The PEITHO-2 trial was funded by the German Federal Ministry of Education and Research, University Medical Center Mainz, and Boehringer Ingelheim.","id":[{"id":"https:\/\/ror.org\/04pz7b180","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100014584","name":"Universit\u00e4tsmedizin der Johannes Gutenberg-Universit\u00e4t Mainz","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014584","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Right ventricular (RV) function plays a critical role in the pathophysiology and acute prognosis of pulmonary embolism (PE). We analyzed the temporal changes of RV function in the cohort of a prospective multicentre study investigating if an early switch to oral anticoagulation in patients with intermediate-risk PE is effective and safe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Echocardiographic and laboratory examinations were performed at baseline (PE diagnosis), 6\u00a0days and 6\u00a0months. Echocardiographic parameters were classified into categories representing RV size, RV free wall\/tricuspid annulus motion, RV pressure overload and right atrial (RA)\/central venous pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>RV dysfunction based on any abnormal echocardiographic parameter was present in 84% of patients at baseline. RV dilatation was the most frequently abnormal finding (40.6%), followed by increased RA\/central venous pressure (34.6%), RV pressure overload (32.1%), and reduced RV free wall\/tricuspid annulus motion (20.9%). As early as day 6, RV size remained normal or improved in 260 patients (64.7%), RV free wall\/tricuspid annulus motion in 301 (74.9%), RV pressure overload in 297 (73.9%), and RA\/central venous pressure in 254 (63.2%). At day 180, the frequencies slightly increased. The median NT-proBNP level decreased from 1448\u00a0pg\/ml at baseline to 256.5 on day 6 and 127 on day 180.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the majority of patients with acute intermediate-risk PE switched early to a direct oral anticoagulant, echocardiographic parameters of RV function normalised within 6\u00a0days and remained normal throughout the first 6\u00a0months. Almost one in four patients, however, continued to have evidence of RV dysfunction over the long term.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-022-02138-4","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T22:02:30Z","timestamp":1671573750000},"page":"1372-1381","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2"],"prefix":"10.1007","volume":"112","author":[{"given":"Anna C.","family":"Mavromanoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Barco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Ageno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Bouvaist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Brodmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Cuccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Couturaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Dellas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Dimopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Duerschmied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Empen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pompilio","family":"Faggiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emile","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazzareno","family":"Gali\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Galvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Ghuysen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Giannakoulas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno V.","family":"Huisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matija","family":"Kozak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene M.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Meneveau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"M\u00fcnzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Palazzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoniu Octavian","family":"Petris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Piovaccari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Salvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Schellong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Helge","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Verschuren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Schmidtmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit","family":"Toenges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederikus A.","family":"Klok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6359-7279","authenticated-orcid":false,"given":"Stavros V.","family":"Konstantinides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The PEITHO-2 Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime Antonio Abelaira","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Anusic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothea","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bertoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Bettoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Carels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Di Pasquale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"D\u00fcrschmied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iolanda","family":"Enea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Ficker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Genth-Zotz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Girard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Gorbulev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Held","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Hobohm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno V","family":"Huisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros V","family":"Konstantinides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Kronfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene Marthe","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mareike","family":"Lankeit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Lehmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepcion Patricia Lopez","family":"Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Pareznik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Quitzau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irinel Raluca","family":"Parepa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purificacion Ramirez","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Righini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silviu Bogdan","family":"Todea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Torbicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Valerio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Vanassche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luminita Animarie","family":"Vida-Simiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamaria","family":"Wolf-P\u00fctz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"key":"2138_CR1","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1093\/EURHEARTJ\/EHZ405","volume":"41","author":"SV Konstantinides","year":"2020","unstructured":"Konstantinides SV, Meyer G, Bueno H et al (2020) 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS)The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Heart J 41:543\u2013603. https:\/\/doi.org\/10.1093\/EURHEARTJ\/EHZ405","journal-title":"Eur Heart J"},{"key":"2138_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/NRDP.2018.28","author":"MV Huisman","year":"2018","unstructured":"Huisman MV, Barco S, Cannegieter SC et al (2018) Pulmonary embolism. Nat Rev Dis Prim. https:\/\/doi.org\/10.1038\/NRDP.2018.28","journal-title":"Nat Rev Dis Prim"},{"key":"2138_CR3","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1002\/EJHF.478","volume":"18","author":"VP Harjola","year":"2016","unstructured":"Harjola VP, Mebazaa A, \u010celutkiene J et al (2016) Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology. Eur J Heart Fail 18:226\u2013241. https:\/\/doi.org\/10.1002\/EJHF.478","journal-title":"Eur J Heart Fail"},{"key":"2138_CR4","doi-asserted-by":"publisher","first-page":"R103","DOI":"10.1186\/CC10119","volume":"15","author":"G Coutance","year":"2011","unstructured":"Coutance G, Cauderlier E, Ehtisham J et al (2011) The prognostic value of markers of right ventricular dysfunction in pulmonary embolism: a meta-analysis. Crit Care 15:R103. https:\/\/doi.org\/10.1186\/CC10119","journal-title":"Crit Care"},{"key":"2138_CR5","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1001\/ARCHINTE.166.19.2151","volume":"166","author":"S Grifoni","year":"2006","unstructured":"Grifoni S, Vanni S, Magazzini S et al (2006) Association of persistent right ventricular dysfunction at hospital discharge after acute pulmonary embolism with recurrent thromboembolic events. Arch Intern Med 166:2151\u20132156. https:\/\/doi.org\/10.1001\/ARCHINTE.166.19.2151","journal-title":"Arch Intern Med"},{"key":"2138_CR6","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1007\/S00392-018-1405-1","volume":"108","author":"S Barco","year":"2019","unstructured":"Barco S, Russo M, Vicaut E et al (2019) Incomplete echocardiographic recovery at 6 months predicts long-term sequelae after intermediate-risk pulmonary embolism. A post-hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial. Clin Res Cardiol 108:772. https:\/\/doi.org\/10.1007\/S00392-018-1405-1","journal-title":"Clin Res Cardiol"},{"key":"2138_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12890-020-01380-8\/FIGURES\/3","volume":"21","author":"Y Gao","year":"2021","unstructured":"Gao Y, Chen L, Jia D (2021) A predictive tool for the assessment of right ventricular dysfunction in non-high-risk patients with acute pulmonary embolism. BMC Pulm Med 21:1\u20139. https:\/\/doi.org\/10.1186\/S12890-020-01380-8\/FIGURES\/3","journal-title":"BMC Pulm Med"},{"key":"2138_CR8","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1016\/S0735-1097(02)01915-0","volume":"39","author":"II Tulevski","year":"2002","unstructured":"Tulevski II, Mulder BJM, van Veldhuisen DJ (2002) Utility of a BNP as a marker for RV dysfunction in acute pulmonary embolism. J Am Coll Cardiol 39:2080. https:\/\/doi.org\/10.1016\/S0735-1097(02)01915-0","journal-title":"J Am Coll Cardiol"},{"key":"2138_CR9","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1007\/S00134-006-0482-1","volume":"33","author":"D Logeart","year":"2007","unstructured":"Logeart D, Lecuyer L, Thabut G et al (2007) Biomarker-based strategy for screening right ventricular dysfunction in patients with non-massive pulmonary embolism. Intensive Care Med 33:286\u2013292. https:\/\/doi.org\/10.1007\/S00134-006-0482-1","journal-title":"Intensive Care Med"},{"key":"2138_CR10","doi-asserted-by":"publisher","first-page":"e627","DOI":"10.1016\/S2352-3026(21)00203-9","volume":"8","author":"FA Klok","year":"2021","unstructured":"Klok FA, Toenges G, Mavromanoli AC et al (2021) Early switch to oral anticoagulation in patients with acute intermediate-risk pulmonary embolism (PEITHO-2): a multinational, multicentre, single-arm, phase 4 trial. Lancet Haematol 8:e627\u2013e636. https:\/\/doi.org\/10.1016\/S2352-3026(21)00203-9","journal-title":"Lancet Haematol"},{"key":"2138_CR11","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1160\/TH17-06-0434","volume":"117","author":"FA Klok","year":"2017","unstructured":"Klok FA, Ageno W, Barco S et al (2017) Dabigatran after short heparin anticoagulation for acute intermediate-risk pulmonary embolism: rationale and design of the single-arm PEITHO-2 study. Thromb Haemost 117:2425\u20132434. https:\/\/doi.org\/10.1160\/TH17-06-0434","journal-title":"Thromb Haemost"},{"key":"2138_CR12","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1093\/EURHEARTJ\/EHU283","volume":"35","author":"SV Konstantinides","year":"2014","unstructured":"Konstantinides SV, Torbicki A, Agnelli G et al (2014) 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolismThe Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC)Endorsed by the European Respiratory Society (ERS). Eur Heart J 35:3033\u20133080. https:\/\/doi.org\/10.1093\/EURHEARTJ\/EHU283","journal-title":"Eur Heart J"},{"key":"2138_CR13","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/J.ECHO.2010.05.010","volume":"23","author":"LG Rudski","year":"2010","unstructured":"Rudski LG, Lai WW, Afilalo J et al (2010) Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr 23:685\u2013713. https:\/\/doi.org\/10.1016\/J.ECHO.2010.05.010","journal-title":"J Am Soc Echocardiogr"},{"key":"2138_CR14","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1183\/09031936.00211613","volume":"43","author":"M Lankeit","year":"2014","unstructured":"Lankeit M, Jim\u00e9nez D, Kostrubiec M et al (2014) Validation of N-terminal pro-brain natriuretic peptide cut-off values for risk stratification of pulmonary embolism. Eur Respir J 43:1669\u20131677. https:\/\/doi.org\/10.1183\/09031936.00211613","journal-title":"Eur Respir J"},{"key":"2138_CR15","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1164\/RCCM.200803-459OC","volume":"178","author":"FA Klok","year":"2008","unstructured":"Klok FA, Mos ICM, Huisman MV (2008) Brain-type natriuretic peptide levels in the prediction of adverse outcome in patients with pulmonary embolism: a systematic review and meta-analysis. Am J Respir Crit Care Med 178:425\u2013430. https:\/\/doi.org\/10.1164\/RCCM.200803-459OC","journal-title":"Am J Respir Crit Care Med"},{"key":"2138_CR16","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1161\/01.CIR.99.10.1325","volume":"99","author":"A Ribeiro","year":"1999","unstructured":"Ribeiro A, Lindmarker P, Johnsson H et al (1999) Pulmonary embolism: one-year follow-up with echocardiography doppler and five-year survival analysis. Circulation 99:462\u2013466. https:\/\/doi.org\/10.1161\/01.CIR.99.10.1325","journal-title":"Circulation"},{"key":"2138_CR17","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1093\/EURHEARTJ\/EHM295","volume":"28","author":"BG Stevinson","year":"2007","unstructured":"Stevinson BG, Hernandez-Nino J, Rose G, Kline JA (2007) Echocardiographic and functional cardiopulmonary problems 6 months after first-time pulmonary embolism in previously healthy patients. Eur Heart J 28:2517\u20132524. https:\/\/doi.org\/10.1093\/EURHEARTJ\/EHM295","journal-title":"Eur Heart J"},{"key":"2138_CR18","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1016\/J.JACC.2016.12.039","volume":"69","author":"SV Konstantinides","year":"2017","unstructured":"Konstantinides SV, Vicaut E, Danays T et al (2017) Impact of thrombolytic therapy on the long-term outcome of intermediate-risk pulmonary embolism. J Am Coll Cardiol 69:1536\u20131544. https:\/\/doi.org\/10.1016\/J.JACC.2016.12.039","journal-title":"J Am Coll Cardiol"},{"key":"2138_CR19","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1093\/EURHEARTJ\/EHAB816","volume":"43","author":"FA Klok","year":"2022","unstructured":"Klok FA, Ageno W, Ay C et al (2022) Optimal follow-up after acute pulmonary embolism: a position paper of the European Society of Cardiology Working Group on Pulmonary Circulation and Right Ventricular Function, in collaboration with the European Society of Cardiology Working Group on Atherosclerosis and Vascular Biology, endorsed by the European Respiratory Society. Eur Heart J 43:183\u2013189. https:\/\/doi.org\/10.1093\/EURHEARTJ\/EHAB816","journal-title":"Eur Heart J"},{"key":"2138_CR20","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1378\/CHEST.08-2988","volume":"136","author":"JA Kline","year":"2009","unstructured":"Kline JA, Steuerwald MT, Marchick MR et al (2009) Prospective evaluation of right ventricular function and functional status 6 months after acute submassive pulmonary embolism: frequency of persistent or subsequent elevation in estimated pulmonary artery pressure. Chest 136:1202. https:\/\/doi.org\/10.1378\/CHEST.08-2988","journal-title":"Chest"},{"key":"2138_CR21","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1160\/TH13-07-0538","volume":"112","author":"L Gu\u00e9rin","year":"2014","unstructured":"Gu\u00e9rin L, Couturaud F, Parent F et al (2014) Prevalence of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Prevalence of CTEPH after pulmonary embolism. Thromb Haemost 112:598\u2013605. https:\/\/doi.org\/10.1160\/TH13-07-0538","journal-title":"Thromb Haemost"},{"key":"2138_CR22","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1161\/CIRCULATIONAHA.106.171016","volume":"113","author":"P Poirier","year":"2006","unstructured":"Poirier P, Giles TD, Bray GA et al (2006) Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 113:898\u2013918. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.106.171016","journal-title":"Circulation"},{"key":"2138_CR23","doi-asserted-by":"publisher","first-page":"160","DOI":"10.5935\/ABC.20130142","volume":"101","author":"A Sokmen","year":"2013","unstructured":"Sokmen A, Sokmen G, Acar G et al (2013) The impact of isolated obesity on right ventricular function in young adults. Arq Bras Cardiol 101:160. https:\/\/doi.org\/10.5935\/ABC.20130142","journal-title":"Arq Bras Cardiol"},{"key":"2138_CR24","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/J.JCMG.2009.10.012","volume":"3","author":"EB Turkbey","year":"2010","unstructured":"Turkbey EB, McClelland RL, Kronmal RA et al (2010) The impact of obesity on the left ventricle: the Multi-Ethnic Study of Atherosclerosis (MESA). JACC Cardiovasc Imaging 3:266. https:\/\/doi.org\/10.1016\/J.JCMG.2009.10.012","journal-title":"JACC Cardiovasc Imaging"},{"key":"2138_CR25","doi-asserted-by":"publisher","first-page":"00163","DOI":"10.1183\/23120541.00163-2019","volume":"6","author":"LFM Beenen","year":"2020","unstructured":"Beenen LFM, Scheres LJJ, Stoker J, Middeldorp S (2020) Prognostic characteristics and body mass index in patients with pulmonary embolism: does size matter? ERJ Open Res 6:00163\u201302019. https:\/\/doi.org\/10.1183\/23120541.00163-2019","journal-title":"ERJ Open Res"},{"key":"2138_CR26","doi-asserted-by":"publisher","DOI":"10.1093\/EURHEARTJ\/EHAC206","author":"L Valerio","year":"2022","unstructured":"Valerio L, Mavromanoli AC, Barco S et al (2022) Chronic thromboembolic pulmonary hypertension and impairment after pulmonary embolism: the FOCUS study. Eur Heart J. https:\/\/doi.org\/10.1093\/EURHEARTJ\/EHAC206","journal-title":"Eur Heart J"}],"container-title":["Clinical Research in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-022-02138-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00392-022-02138-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00392-022-02138-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T05:03:07Z","timestamp":1696827787000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00392-022-02138-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,21]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["2138"],"URL":"https:\/\/doi.org\/10.1007\/s00392-022-02138-4","relation":{},"ISSN":["1861-0684","1861-0692"],"issn-type":[{"value":"1861-0684","type":"print"},{"value":"1861-0692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,21]]},"assertion":[{"value":"18 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"SB reports grants or contracts from Bayer, INARI, Boston Scientific, Medtronic, Bard, SANOFI, and Concept Medical; consulting fees from INARI; payment or honoraria from INARI, Boston Scientific, and Concept Medical; and support for attending meetings and\/or travel from Bayer and Daiichi Sankyo. WA reports grants or contracts from Bayer; payment or honoraria from Bayer, Daiichi Sankyo, Pfizer-BMS, Werfen, Aspen, and Leo Pharma; and participation on a Data Safety Monitoring Board or Advisory Board for Bayer, BMS-Pfizer, Sanofi, Viatris, Norgine, and Leo Pharma. FC reports grants or contracts from Bayer and BMS Pfizer; consulting fees from Bayer, BMS, Pfizer, and Astra; and support for attending meetings and\/or travel from Bayer, BMS\/Pfizer, Leo Pharma, and Actelion. KD reports unrestricted research support and speaker\/consultant fees from Janssen. DD reports consulting fees from Boston Scientific; payment or honoraria from Bayer Healthcare, Daiichi Sankyo, BMS\/Pfizer, and Leo Pharma; support for attending meetings and\/or travel from Bayer Healthcare, Daiichi Sankyo, and BMS\/Pfizer; and participation on a Data Safety Monitoring Board or Advisory Board for Bayer Healthcare and Daiichi Sankyo. KE reports consulting fees from Bayer Vital. GG reports consulting fees, payment or honoraria from Bayer, Boehringer Ingelheim, Leo, and Pfizer. MVH reports grants from ZonMW Dutch Healthcare Fund, Boehringer Ingelheim, Bristol-Myers Squibb\/Pfizer, Bayer Health Care, Aspen, and Daiichi-Sankyo. DJ reports grants or contracts from Daiichi Sankyo, Sanofi, and ROVI; and consulting fees, payment or honoraria from Bayer HealthCare Pharmaceuticals, Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo, Leo Pharma, Pfizer, ROVI, and Sanofi. MK reports payment or honoraria from Pfizer, Boehringer Ingelheim, and Bayer AG. IML reports grants or contracts and consulting fees from Janssen and AOPHealth; payment or honoraria from MSD, Ferrer, Janssen, and AOPHealth; and support for attending meetings and\/or travel from Novomed. NM reports grants or contracts from BMS\/Pfizer, Bayer Healthcare, Medtronic, and Abbott; consulting fees from INARI, Boston Scientific, Terumo, and Abbott; payment or honoraria and support for attending meetings and\/or travel from BMS-Pfizer, Bayer Healthcare, and Abbott; and participation on a Data Safety Monitoring Board or Advisory Board for INARI, Boston Scientific, Terumo, and Abbott. AOP reports payment or honoraria from AlfaSigma Romania SRL, Terapia SA Romania, Servier Pharma SRL, Pfizer Romania SRL, Boehringer Ingelheim, SC Bayer SRL, Egis Pharmaceuticals RLC, Novartis Pharma Services Romania SRL, S\u2009>\u2009C\u2009>\u2009Berlin-Chemie Menarini SRL, Zentiva SRL, and Sanofi Romania RL. SS reports consulting fees and speaker fees from Aspen and Boehringer Ingelheim, speaker fees from Bayer AG and Daiichi-Sankyo, and project funding and speaker fees from Pfizer\/Bristol-Myers Squibb. FV reports research grants from Daiichi-Sanyo, Boehringer Ingelheim, Radiometer, and Biomerieux. IS reports stock or stock options from Dr\u00e4ger. FAK reports grants or contracts from Bayer, BMS, Boehringer Ingelheim, MSD, Daiichi Sankyo, and Actelion. SVK reports grants or contracts from Bayer AG; consulting fees from Bayer AG, Daiichi Sankyo, and Boston Scientific; and payment or honoraria from Bayer AG, Boston Scientific, MSD, Pfizer, and Bristol-Myers Squibb. All other authors (ACM, HB, MB, CC, CD, PF, EF, NG, MG, AG, TM, MP, GP, AS, K-HS, GT) declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}