{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T16:40:23Z","timestamp":1781023223872,"version":"3.54.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Patients undergoing left atrial appendage (LAA) occlusion (LAAO) are multi-morbid, including mitral valve disease (MVD) which is associated with anatomic changes of the left atrium (LA). This study aims to identify how atrial myopathy in MVD influences outcomes in LAAO.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Atrial myopathy in MVD was defined as LA diameter\u2009&gt;\u200945\u00a0mm (\u2640) and\u2009&gt;\u200948\u00a0mm (\u2642) and existing MVD or history of surgical\/interventional treatment. Patients were compared with controls from the prospective, multicentre LAArge registry of LAAO.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 528 patients (52 MVD, 476 no-MVD) were included. The MVD group was significantly more likely to be older (78.2\u00a0years vs 75.9\u00a0years, <jats:italic>p<\/jats:italic>\u2009=\u20090.036) and female (59.6% vs 37.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.002). Altered LA anatomy was observed in MVD with significantly larger LA diameter (53\u00a0mm vs. 48\u00a0mm, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and LAA Ostia [at 135\u00b0 23.0\u00a0mm (20.5, 26.0) vs 20.0\u00a0mm (18.0, 23.0), <jats:italic>p<\/jats:italic>\u2009=\u20090.002]. Implant success was high with 96.2% and 97.9%, respectively, without differences in severe complications (7.7% vs 4.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.31). One-year mortality (17.8% vs 11.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.19) and a combined outcome of death, stroke, and systemic embolism (20.3% vs 12.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.13) were not different. Independent predictors of the combined outcome were peripheral artery disease (HR 2.41, 95% CI 1.46\u20133.98, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and chronic kidney disease (HR 3.46, 95% CI 2.02\u20135.93, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) but not MVD and atrial myopathy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Patients with MVD present with altered LA anatomy with increased LA and LAA diameter. However, procedural success and safety in LAAO are not compromised. One-year mortality is numerically higher in patients with MVD but driven by comorbidities.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00392-022-02151-7","type":"journal-article","created":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T11:02:52Z","timestamp":1675594972000},"page":"824-833","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of atrial myopathy in mitral valve disease on safety outcomes in left atrial appendage closure"],"prefix":"10.1007","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8113-733X","authenticated-orcid":false,"given":"Shinwan","family":"Kany","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Skibowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus-Heinrich","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Geist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feraydoon","family":"Niroomand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Hailer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Pleger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hochadel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Senges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Lubos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,5]]},"reference":[{"key":"2151_CR1","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.113.005119","volume":"129","author":"SS Chugh","year":"2014","unstructured":"Chugh SS et al (2014) Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. 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Outside the submitted work EL received personal fees from Abiomed, Astra Zeneca, Bayer, Edwards Lifesciences, New Valve Technology and Novartis. Other authors report no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}