{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:45:47Z","timestamp":1791639947466,"version":"4.3.4"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Aims<\/jats:title>\n                <jats:p>This study was performed to compare haemodynamic properties of a novel transcatheter heart valve (THV) with two established valve technologies for treatment of failing surgical aortic bioprosthetic valves (SAV). The ALLEGRA THV has been recently described with a proven safety and performance profile.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods and results<\/jats:title>\n                <jats:p>The study was designed as a retrospective, single-centre study investigating 112 patients (77.7\u2009\u00b1\u20097.1\u00a0years, 53.8%\u00a0female, STS score 6.8\u2009\u00b1\u20095.8% and logEuroSCORE I 27.4\u2009\u00b1\u200916.1%) with failing SAV. Patients were treated with the ALLEGRA THV (NVT, n\u2009=\u200924), the CoreValve\/EvolutR (MTD, n\u2009=\u200964) or the Edwards Sapien\/Sapien XT\/Sapien 3 (EDW, n\u2009=\u200924). Adverse events, haemodynamic outcomes and patient safety were analysed according to VARC-3 definitions. Overall procedural success was high (94.6%), even though 58.9% of the treated SAV were classified as small (true inner diameter\u2009&lt;\u200921\u00a0mm). After treatment, the\u00a0mean pressure gradient was significantly reduced (baseline: 33.7\u2009\u00b1\u200916.5\u00a0mmHg, discharge: 18.0\u2009\u00b1\u20097.1\u00a0mmHg), with a corresponding increase in\u00a0effective orifice area (EOA). The complication rates did not differ in between groups. There was a trend to lower mean transvalvular gradients after implantation of self-expanding THV with supra-annular valve function, despite a higher frequency of smaller SAVs in the NVT and MTD group. Additionally, comparison between NVT and MTD revealed statistically lower transvalvular gradients (NVT 14.9\u2009\u00b1\u20095.0\u00a0mmHg, MTD 18.7\u2009\u00b1\u20097.5\u00a0mmHg, <jats:italic>p<\/jats:italic>\u2009=\u2009<jats:italic>0.0295<\/jats:italic>) in a subgroup analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Valve-in-valve (ViV) treatment of failing SAV with supra-annular design like the ALLEGRA THV resulted in favourable haemodynamic outcomes with similar low clinical event rates and may therefore be an interesting alternative for VIV TAVI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00392-023-02181-9","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T09:58:38Z","timestamp":1680688718000},"page":"18-28","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of a novel self-expanding transcatheter heart valve with two established devices for treatment of degenerated surgical aortic bioprostheses"],"prefix":"10.1007","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2784-0205","authenticated-orcid":false,"given":"Olga","family":"Nikolayevska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenard","family":"Conradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schirmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Reichenspurner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Deuschl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Blankenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,5]]},"reference":[{"issue":"1","key":"2181_CR1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.athoracsur.2014.06.050","volume":"99","author":"VH Thourani","year":"2015","unstructured":"Thourani VH, Suri RM, Gunter RL, Sheng S, O\u2019Brien SM, Ailawadi G, Szeto WY, Dewey TM, Guyton RA, Bavaria JE, Babaliaros V, Gammie JS, Svensson L, Williams M, Badhwar V, Mack MJ (2015) Contemporary real-world outcomes of surgical aortic valve replacement in 141,905 low-risk, intermediate-risk, and high-risk patients. 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Nikolayevska, J. Schirmer and S. Blankenberg have no relevant financial or non-financial interests to disclose. L. Conradi has served on advisory boards for Medtronic, Abbott Vascular, JenaValve Technology, Neovasc Medical and the speaker bureau of Edwards Lifesciences, BostonScientific, Microinterventions, LivaNova and New Valve Technology. U. Sch\u00e4fer has served on advisory boards for Abbott and New Valve Technology and the speaker bureau of Edwards Lifesciences, BostonScientific, New Valve Technology and Abbott Vascular. H. Reichenspurner received consulting fees from Medtronic Inc., and support for attending meetings and\/or travel by Medtronic Inc., F. Deuschl is a full-time employee at at Edwards Lifesciences since October 2018 and received Grant Support for the VIVALL Study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}