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Radiological parameters for noninvasive detection of PH, most importantly computed tomography (CT) based PA\/AA-ratio\u2009=\u2009ratio of pulmonary artery diameter (PA) and ascending aorta diameter (AA), are also included in the latest ESC guidelines. The aim of the present study was to define cut-off values for PA\/AA-ratio taking also into account cardiovascular biomarkers to determine criteria for noninvasive diagnosis of PH.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>194 patients with severe AS undergoing transcatheter aortic valve replacement (TAVR) underwent pre-procedural TTE and CT with measurement of PA\/AA-ratio. Additionally, common cardiovascular biomarkers were determined.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>TAVR patients with an sPAP\u2009\u2265\u200940\u00a0mmHg or a TRVmax\u2009\u2265\u20092.9\u00a0m\/s had a PA\/AA-ratio\u2009\u2265\u20090.80 in an AUROC analysis. The cut-off value of\u2009\u2265\u20090.80 resulted in a significantly higher mortality rate (log-rank test: p\u2009=\u20090.034) in these patients in a Kaplan\u2013Meier analysis regarding 1-year survival after TAVR. Significant differences in biomarker expression between patients with a PA\/AA-ratio\u2009\u2265\u20090.80 or\u2009&lt;\u20090.80 occurred for BNP (p\u2009=\u20090.001), cTnI (p\u2009=\u20090.032), GDF-15 (p\u2009=\u20090.002) and H-FABP (p\u2009=\u20090.015).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>PA\/AA-ratio\u2009\u2265\u20090.80 is a promising radiological parameter that can provide information about mortality in patients with severe AS undergoing TAVR; combined with biomarkers it may contribute to noninvasive detection of PH in patients with severe AS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00392-023-02182-8","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T02:02:43Z","timestamp":1679277763000},"page":"1394-1416","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["CT measured pulmonary artery to ascending aorta ratio stratified by echocardiographically obtained systolic pulmonary artery pressure values for noninvasive detection of pulmonary hypertension in patients with severe aortic valve stenosis"],"prefix":"10.1007","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6589-3853","authenticated-orcid":false,"given":"Elke","family":"Boxhammer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kletzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Kellermair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Scharinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hammerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Blessberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Steinwender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lichtenauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Hergan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta C.","family":"Hoppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2405-2350","authenticated-orcid":false,"given":"Stefan","family":"Hecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,20]]},"reference":[{"issue":"2","key":"2182_CR1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.tcm.2020.12.005","volume":"32","author":"MT Maeder","year":"2022","unstructured":"Maeder MT, Weber L, Rickli H (2022) Pulmonary hypertension in aortic valve stenosis. 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