{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T02:45:35Z","timestamp":1768617935039,"version":"3.49.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Heart and Diabetes Centre North Rhine-Westphalia (DKZ NRW)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Recent data demonstrated the benefit of left atrial appendage (LAA)-amputation in patients with atrial fibrillation (AF). However, the long-term impact of LAA-amputation for patients with new-onset perioperative atrial fibrillation (POAF) is still unknown.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients with no history of AF undergoing coronary artery bypass grafting by off-pump technique (OPCAB) between 2014 and 2016 were retrospectively examined. Cohorts were divided by the concomitant execution of LAA-amputation. Propensity score (PS) matching was applied by all available baseline characteristics. The composite of all-cause mortality, stroke and rehospitalization in patients with POAF and patients maintaining sinus rhythm posed as the primary endpoint.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 1522 patients were enrolled, of whom 1208 and 243 were included in the control and the LAA-amputation group, respectively and were matched to 243 patients in each group. In total, patients with POAF without LAA-amputation showed a significantly higher rate of the composite endpoint (17.3% vs 32.1%, p\u2009=\u20090.007). However, patients with LAA-amputation showed no significant difference in the composite endpoint (23.2% vs 26.7%, p\u2009=\u20090.57). The significantly higher occurrence of the composite endpoint was driven by all-cause mortality (p\u2009=\u20090.005) and rehospitalization (p\u2009=\u20090.029). Subgroup analysis revealed a CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-VASc-score of\u2009\u2265\u20093 to be associated with the high rate of the primary endpoint (p\u2009=\u20090.004).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>POAF is associated with a higher rate of the combined endpoint of all-cause mortality, stroke and rehospitalization. The composite endpoint in patients with LAA-amputation concomitant with OPCAB surgery developing new-onset POAF in a 5-year follow-up was not increased compared to a control cohort maintaining sinus rhythm.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                <jats:p>Five-year outcome of patients with POAF and LAA-amputation; <jats:italic>95% CI<\/jats:italic>, 95% confidence interval, <jats:italic>CPR,<\/jats:italic> cardiopulmonary resuscitation, <jats:italic>ECLS,<\/jats:italic> extracorporeal life support, <jats:italic>HR,<\/jats:italic> hazard ratio, <jats:italic>IABP<\/jats:italic>, intra-aortic balloon pump, <jats:italic>LAA<\/jats:italic>, left atrial appendage, <jats:italic>OPCAB<\/jats:italic>, off-pump coronary artery bypass grafting, <jats:italic>PAPs<\/jats:italic>, systolic pulmonary artery pressure, <jats:italic>SR<\/jats:italic>, sinus rhythm, <jats:italic>VT,<\/jats:italic> ventricular tachycardia.<\/jats:p>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00392-023-02255-8","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T04:01:46Z","timestamp":1688961706000},"page":"1800-1811","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Five-year-outcome of new-onset perioperative atrial fibrillation after left atrial appendage amputation concomitant with cardiac surgery"],"prefix":"10.1007","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6751-4650","authenticated-orcid":false,"given":"Mustafa","family":"Ger\u00e7ek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2891-6320","authenticated-orcid":false,"given":"Jochen","family":"B\u00f6rgermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6956-9110","authenticated-orcid":false,"given":"Jan","family":"Gummert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1822-936X","authenticated-orcid":false,"given":"Muhammed","family":"Ger\u00e7ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"2255_CR1","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/j.jtcvs.2010.10.040","volume":"141","author":"R Kaw","year":"2011","unstructured":"Kaw R, Hernandez AV, Masood I, Gillinov AM, Saliba W, Blackstone EH (2011) Short- and long-term mortality associated with new-onset atrial fibrillation after coronary artery bypass grafting: a systematic review and meta-analysis. 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