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Associations with 6-week functional outcomes and clinical outcomes during a median follow-up period of 594\u00a0days were examined.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of 661 patients (mean age 79\u00a0years; age-range 37\u2013101\u00a0years; 56.1% men), 21.6% had a history of cancer with active disease in 4.1%. Compared with non-cancer patients, cancer patients had a similar procedural success rate (reduction of mitral regurgitation to grade 2 or lower 91.6% vs. 88%; p\u2009=\u20090.517) and similar relevant improvement in 6-min walking distance, NYHA class, Minnesota Living with Heart Failure Questionnaire score and Short Form 36 scores. 1-year survival (83% vs. 82%; p\u2009=\u20090.813) and 1-year survival free of heart failure decompensation (75% vs. 76%; p\u2009=\u20090.871) were comparable between cancer and non-cancer patients. Patients with an active cancer disease showed significantly higher mortality compared with patients having a history of cancer (hazard ratio 2.05 [95% CI 1.11\u20133.82; p\u2009=\u20090.023]) but similar mortality at landmark analysis of 1\u00a0year.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>TMVR can be performed with equal efficacy in patients with and without cancer and symptomatic mitral regurgitation. Cancer patients show comparable clinical outcome and short-term functional improvement as non-cancer patients. However, longterm mortality was increased in patients with active cancer underlining the importance of patient selection within the heart-team evaluation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00392-023-02266-5","type":"journal-article","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T14:02:43Z","timestamp":1692108163000},"page":"94-106","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic impact of cancer history in patients undergoing transcatheter mitral valve repair"],"prefix":"10.1007","volume":"113","author":[{"given":"Alev","family":"Kalkan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Metze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Iliadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"K\u00f6rber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,15]]},"reference":[{"key":"2266_CR1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00392-013-0614-x","volume":"103","author":"P Boekstegers","year":"2014","unstructured":"Boekstegers P, Hausleiter J, Baldus S et al (2014) Percutaneous interventional mitral regurgitation treatment using the Mitra-Clip system. 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