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We assessed the association of CNR with adverse outcomes in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES) and newer antithrombotic drugs, ticagrelor or prasugrel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study included 3100 patients with AMI who underwent PCI with current DES and third-generation P2Y\n                      <jats:sub>12<\/jats:sub>\n                      inhibitors. CNR was defined as Thrombolysis in Myocardial Infarction (TIMI) blood flow grade\u2009\u2264\u20092 at the end of PCI. The primary end point was 1-year incidence of net adverse clinical and cerebral events\u2014a composite end point of death of any cause, myocardial infarction, stroke or major bleeding.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CNR was diagnosed in 130 patients (4.2%). The primary end point occurred in 28 patients in the CNR group and 354 patients in the reflow group (cumulative incidence 23.2% and 12.8%; adjusted hazard ratio\u2009=\u20091.53, 95% confidence interval 1.01\u20132.33;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.049). The 1-year incidences of death or myocardial infarction (14.6% vs. 7.6%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003), myocardial infarction (8.8% vs. 3.9%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.007) and major bleeding (10.9% vs. 5.6%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.008) were significantly higher in patients with CNR than patients with reflow. The risk of adverse events in patients with CNR was highest within the first 30\u00a0days after PCI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In patients with AMI undergoing PCI with current DES and third generation P2Y\n                      <jats:sub>12<\/jats:sub>\n                      receptor inhibitors, CNR was associated with a higher risk of adverse outcomes at 1\u00a0year.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-023-02340-y","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T07:02:01Z","timestamp":1699945321000},"page":"1006-1016","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Coronary no-reflow and adverse events in patients with acute myocardial infarction after percutaneous coronary intervention with current drug-eluting stents and third-generation P2Y12 inhibitors"],"prefix":"10.1007","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8725-055X","authenticated-orcid":false,"given":"Gjin","family":"Ndrepepa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Cassese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erion","family":"Xhepa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Joner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik B.","family":"Sager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Kufner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Ludwig","family":"Laugwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heribert","family":"Schunkert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Kastrati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"2340_CR1","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1172\/JCI107898","volume":"54","author":"RA Kloner","year":"1974","unstructured":"Kloner RA, Ganote CE, Jennings RB (1974) The \u201cno-reflow\u201d phenomenon after temporary coronary occlusion in the dog. 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