{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:15:30Z","timestamp":1789402530886,"version":"build-2803163510"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["BMBF 01EO1504"],"award-info":[{"award-number":["BMBF 01EO1504"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universit\u00e4tsklinikum W\u00fcrzburg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Aims<\/jats:title>\n                <jats:p>Transcatheter aortic valve implantation (TAVI) has emerged as the treatment of choice for many patients with severe symptomatic aortic stenosis. We sought to identify the echocardiographic predictors of 30-day and 1-year outcomes after TAVI in patients with preserved or reduced left ventricular ejection fraction (LVEF).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This single-centre study included 618 aortic stenosis patients (mean age 82\u2009\u00b1\u20096\u00a0years, 47.1% male; 74.8% LVEF\u2009&gt;\u200950%) who underwent balloon-expandable TAVI between July 2009 and October 2018 in our hospital. All patients completed at least 6\u00a0months of follow-up by medical history review or telephone interview (median 24, quartiles 12\u201342\u00a0months). The primary endpoint was all-cause death.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All-cause mortality rate was 5.2% (LVEF\u2009&gt;\u200950%: 4.3% vs. LVEF\u2009\u2264\u200950%: 7.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.141) at 30\u00a0days and 15.4% (LVEF\u2009&gt;\u200950%: 14.7% vs. LVEF\u2009\u2264\u200950%: 17.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.443) at 12\u00a0months post TAVI. Overall all-cause mortality rate was 45.1% (LVEF\u2009&gt;\u200950%: 44.6% vs. LVEF\u2009\u2264\u200950%: 46.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.643). Mean survival time post TAVI was 51\u00a0months [95% CI (48; 55)]. In TAVI patients with LVEF\u2009&gt;\u200950%, multivariate Cox regression analysis revealed several independent predictors for increased risk of death after adjusting for echocardiographic and clinical covariates: TAPSE (\u2264\u200917 vs.\u2009&gt;\u200917\u00a0mm, HR 1.528, <jats:italic>p<\/jats:italic>\u2009=\u20090.016) and sPAP (&gt;\u200930 vs.\u2009\u2264\u200930\u00a0mmHg, HR 1.900, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) for overall mortality, E\/E\u2032 septal for 30-day mortality (&gt;\u200921 vs.\u2009\u2264\u200921, HR 14.462, <jats:italic>p<\/jats:italic>\u2009=\u20090.010) and 12-month mortality (&gt;\u200921 vs.\u2009\u2264\u200921, HR 1.881, <jats:italic>p<\/jats:italic>\u2009=\u20090.026). In TAVI patients with LVEF\u2009\u2264\u200950%, no independent echocardiographic predictors for outcome could be identified.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>LVEF is not a predictor of short- and long-term mortality after TAVI. In patients with preserved LVEF, left ventricular filling pressure (E\/E\u00b4), systolic pulmonary artery pressure (sPAP), and TAPSE are echocardiographic risk factors for increased mortality post TAVI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00392-023-02350-w","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T16:02:05Z","timestamp":1705939325000},"page":"481-495","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Echocardiographic predictors of outcome in severe aortic stenosis patients with preserved or reduced ejection fraction"],"prefix":"10.1007","volume":"113","author":[{"given":"Victoria","family":"Sokalski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Frantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2560-4068","authenticated-orcid":false,"given":"Peter","family":"Nordbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"issue":"7","key":"2350_CR1","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","volume":"43","author":"A Vahanian","year":"2022","unstructured":"Vahanian A et al (2022) 2021 ESC\/EACTS guidelines for the management of valvular heart disease. 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