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The aim of this study was to analyze trends of mortality rates in patients with CHD between 1998 and 2018 in Germany.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Data of registered deaths with an underlying diagnosis of CHD were used to evaluate annual mortality between 1998 and 2018. Polynomial regressions were performed to assess annual changes in CHD-associated mortality rates by age groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>During the 21-year study period, a total of 11,314 deaths were attributed to CHD with 50.9% of deaths in infants (age\u2009&lt;\u20091\u00a0year) and 28.2% in neonates (age\u2009\u2264\u200928\u00a0days). The most frequent underlying CHDs associated with death were hypoplastic left heart syndrome (<jats:italic>n<\/jats:italic>\u2009=\u20091498, 13.2%), left ventricular outflow tract obstruction (<jats:italic>n<\/jats:italic>\u2009=\u20091009, 8.9%), atrial septal defects (<jats:italic>n<\/jats:italic>\u2009=\u2009771, 6.8%), ventricular septal defects (<jats:italic>n<\/jats:italic>\u2009=\u2009697, 6.2%), and tetralogy of Fallot (<jats:italic>n<\/jats:italic>\u2009=\u2009673, 5.9%), and others (<jats:italic>n<\/jats:italic>\u2009=\u20096666, 58.9%). Among all patients, annual CHD-related mortality rates declined significantly between 1998 and 2010 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), followed by a significant annual increase until 2018 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). However, mortality rates in 2018 in all ages were significantly lower than in 1998.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Mortality in CHD patients decreased significantly between 1998 and 2010, but a substantial number of deaths still occurred and even significantly increased in the last 3\u00a0years of the observation period particularly in neonates and infants. This renewed slight increase in mortality rate during the last years was influenced mainly by high-risk neonates and infants. Assessment of factors influencing the mortality rate trends in association with CHD in Germany is urgently needed. Obligatory nationwide registration of death cases in relation to surgical and catheter interventions in CHD patients is necessary to provide additional valuable data on the outcome of CHD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00392-023-02370-6","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T08:02:52Z","timestamp":1709539372000},"page":"750-760","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Trends of mortality rate in patients with congenital heart defects in Germany\u2014analysis of nationwide data of the Federal Statistical Office of Germany"],"prefix":"10.1007","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5752-5866","authenticated-orcid":false,"given":"Hashim","family":"Abdul-Khaliq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphina","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"von Kries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Wagenpfeil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Pfeifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Poryo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"2370_CR1","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","volume":"39","author":"JIE Hoffman","year":"2002","unstructured":"Hoffman JIE, Hoffman JIE, Kaplan S, Kaplan S (2002) The incidence of congenital heart disease. 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