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Transcatheter tricuspid valve repair (TTVr) reduces TR and can improve quality of life (QoL), but the role of preprocedural RVR on TTVr outcomes remains unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Aims<\/jats:title>\n            <jats:p>To investigate the role of RVR on outcomes after TTVr for severe TR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Consecutive patients undergoing TTVr (61% edge-to-edge vs. 39% direct annuloplasty) for severe TR were retrospectively compared by preexisting RVR which was defined as dilation of RV mid-level diameter (&gt;\u200935\u00a0mm) according to guidelines. QoL was evaluated using NYHA class, Minnesota Living with Heart Failure Questionnaire (MLHFQ), 36-Item Short Form Health Survey (SF-36), and 6-min walking distance (6MWD) 1-month after TTVr. Mid-term mortality and heart failure (HF) hospitalization were assessed through 1\u00a0year.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>RVR was present in 137 of 223 patients (61%). Symptoms and QoL improved equally in both groups:\u2009\u2265\u20091 NYHA class (57% vs. 65% of patients with vs. without RVR, respectively), 6MWD (36% vs. 34%), MLHFQ (81% vs. 69%), and SF-36 (68% vs. 65%) improvement. One-year mortality and HF hospitalization were significantly higher in patients with RVR (24% and 30%, respectively) than in patients without (8% and 13%, both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In multivariable analysis, RVR was independently associated with mortality (HR 2.3, 95%CI (1.0\u20135.0), <jats:italic>p<\/jats:italic>\u2009=\u20090.04) and the combined endpoint of mortality or rehospitalization (HR 2.0, 95%CI (1.1\u20133.8), <jats:italic>p<\/jats:italic>\u2009=\u20090.03).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>TTVr was associated with significant QoL improvement after 1\u00a0month, irrespective of RVR. Despite increased mortality and rehospitalization for heart failure, TTVr in the presence of RVR still provides substantial symptomatic benefit for patients with severe TR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical abstract<\/jats:title>\n            <jats:p>Role of preexisting right ventricular remodeling (RVR) in symptoms and prognosis after transcatheter tricuspid valve repair (TTVr).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00392-024-02428-z","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T10:02:26Z","timestamp":1709719346000},"page":"187-202","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Role of preexisting right ventricular remodeling in symptoms and prognosis after transcatheter tricuspid valve repair"],"prefix":"10.1007","volume":"114","author":[{"given":"Marc-Andr\u00e9","family":"Ehrenfels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Fretter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"von Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Isabel","family":"K\u00f6rber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Wienemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7655-8500","authenticated-orcid":false,"given":"Christos","family":"Iliadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"2428_CR1","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1136\/heartjnl-2017-311586","volume":"104","author":"EA Fender","year":"2018","unstructured":"Fender EA, Zack CJ, Nishimura RA (2018) Isolated tricuspid regurgitation: outcomes and therapeutic interventions. 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R.P. has received speaker and consultant honoraria by Abbott and Edwards Lifesciences. All other authors report no conflict of interest. This project has been supported by Koeln Fortune Program\/Faculty of Medicine, University of Cologne.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}