{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:37:34Z","timestamp":1780555054189,"version":"3.54.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Patients undergoing ventricular tachycardia (VT) ablation often present with structural heart disease (SHD) and reduced ejection fraction. Inducing VT by programmed electrical stimulation (PES) puts these patients at risk for hemodynamic instability and cerebral hypoperfusion.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>The present study screens for cerebral oxygen desaturation phases (ODPs) in patients undergoing VT ablation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Forty-seven patients (age 61\u2009\u00b1\u200914\u00a0years, 72% males) underwent ablation of sustained VT with simultaneous neuromonitoring using near-infrared spectroscopy (NIRS).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Analysis of NIRS signal identified ODPs in 29 patients (62%). ODPs were associated with a higher prevalence of ischemic heart disease (IHD) (45% vs. 11%, <jats:italic>p<\/jats:italic>\u2009=\u20090.024), previous VT episodes (<jats:italic>n<\/jats:italic>\u2009=\u200916 vs. 4, <jats:italic>p<\/jats:italic>\u2009=\u20090.018), and VTs inducible by PES (<jats:italic>n<\/jats:italic>\u2009=\u20092.4 vs. 1.2, <jats:italic>p<\/jats:italic>\u2009=\u20090.004). Patients with ODPs were more likely to be admitted to intensive care unit (ICU) (78% vs. 33%, <jats:italic>p<\/jats:italic>\u2009=\u20090.005) and had more in-hospital VT recurrences (24% vs. 0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.034). No differences were observed in VT recurrence\u00a0rates after hospital discharge (41.4% vs. 44.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.60) and left ventricular\u00a0ejection fraction (34% vs. 38%, <jats:italic>p<\/jats:italic>\u2009=\u20090.567). IHD (OR: 32.837, <jats:italic>p<\/jats:italic>\u2009=\u20090.006), ICU admission (OR: 14.112, <jats:italic>p<\/jats:italic>\u2009=\u20090.013), and the number of VTs inducible at PES (OR: 2.705, <jats:italic>p<\/jats:italic>\u2009=\u20090.015) were independently associated with ODPs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>This study registers episodes of cerebral hypoperfusion in 62% of patients undergoing VT ablation and identifies IHD and the number of VTs inducible at PES as possible risk factors for these episodes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00392-024-02493-4","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T12:01:41Z","timestamp":1721131301000},"page":"481-491","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A screening for cerebral deoxygenation during VT ablations in patients with structural heart disease"],"prefix":"10.1007","volume":"114","author":[{"given":"Julian","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4399-7794","authenticated-orcid":false,"given":"Lena","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Halbfass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Nentwich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Berkovitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Barth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"W\u00e4chter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Lehrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Deneke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"issue":"25","key":"2493_CR1","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1161\/CIRCULATIONAHA.122.059598","volume":"145","author":"P Della Bella","year":"2022","unstructured":"Della Bella P, Baratto F, Vergara P, Bertocchi P, Santamaria M, Notarstefano P et al (2022) Does timing of ventricular tachycardia ablation affect prognosis in patients with an implantable cardioverter defibrillator? results from the multicenter randomized PARTITA trial. 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