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The disease stage was determined by endoscopic and patient-reported criteria. Participants underwent CMR for cardiac phenotyping: cine imaging and strain analysis were performed to assess ventricular function. T1 mapping, extracellular volume and late-gadolinium enhanced images were obtained to assess focal and diffuse myocardial fibrosis. Simultaneous T1 and T2 elevation (T1\u2009&gt;\u20091049.3\u00a0ms, T2\u2009&gt;\u200954\u00a0ms) was considered to indicate a myocardial segment was inflamed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>16\/44 (16.4%) IBD patients described dyspnea on exertion and 10\/44 (22.7%) reported chest pain. A-IBD patients showed impaired ventricular function, indicated by reduced global circumferential and radial strain despite preserved left-ventricular ejection fraction. 16% of all IBD patients had focal fibrosis in a non-ischemic pattern. A-IDB patients had increased markers of diffuse left ventricular fibrosis (T1-values: A-IBD: 1022.0\u2009\u00b1\u200934.83\u00a0ms, R-IBD: 1010.10\u2009\u00b1\u200932.88\u00a0ms, HV: 990.61\u2009\u00b1\u200929.35\u00a0ms, p\u2009&lt;\u2009.01). Significantly more participants with A-IDB (8\/26, 30.8%) had at least one inflamed myocardial segment than patients in remission (0\/18) and HV (1\/44, 2.3%, p\u2009&lt;\u2009.01). Markers of diffuse fibrosis correlated with disease activity.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This study, using CMR, provides evidence of myocardial involvement and patterns of adverse left ventricular remodeling in patients with IBD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical trial registration<\/jats:title>\n            <jats:p>ISRCTN30941346<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical abstract<\/jats:title>\n          <\/jats:sec>","DOI":"10.1007\/s00392-024-02503-5","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T04:02:22Z","timestamp":1722830542000},"page":"1164-1175","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cardiovascular magnetic resonance reveals myocardial involvement in patients with active stage of inflammatory bowel disease"],"prefix":"10.1007","volume":"114","clinical-trial-number":[{"clinical-trial-number":"isrctn30941346","registry":"10.18810\/isrctn"}],"author":[{"given":"Maximilian","family":"Fenski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endri","family":"Abazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Gr\u00f6schel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hadler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Kappelmayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Kolligs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Botnar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Philipp","family":"Kunze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3100-1092","authenticated-orcid":false,"given":"Jeanette","family":"Schulz-Menger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"key":"2503_CR1","doi-asserted-by":"publisher","first-page":"s1","DOI":"10.1136\/gutjnl-2019-318484","volume":"68","author":"CA Lamb","year":"2019","unstructured":"Lamb CA, Kennedy NA, Raine T et al (2019) British society of gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. 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