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The objective of this study was to study the natural progression and underlying mechanisms of AAo dilatation after TAVI for bicuspid AS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with a native bicuspid AS and a baseline AAo maximum diameter\u2009&gt;\u200940\u00a0mm treated by TAVI and in whom post-TAVI computed tomography (CT) scans beyond 1\u00a0year were available were included. AAo dilatation was deemed to be either continuous (\u2265\u20092\u00a0mm increase) or stable (&lt;\u20092\u00a0mm increase or decrease). Uni- and multivariate logistic regression analysis was utilized in order to identify factors associated with continuous AAo dilatation post-TAVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 61 patients with a mean AAo maximum diameter of 45.6\u2009\u00b1\u20093.9\u00a0mm at baseline were evaluated. At a median follow-up of 2.9\u00a0years, AAo dimensions remained stable in 85% of patients. Continuous AAo dilatation was observed in 15% of patients at a rate of 1.4\u00a0mm\/year. Factors associated with continuous AAo dilatation were raphe length\/annulus mean diameter ratio (OR 4.09, 95% CI [1.40\u201316.7],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022), TAV eccentricity at the leaflet outflow level (OR 2.11, 95%CI [1.12\u20134.53],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031) and maximum transprosthetic gradient (OR 1.30, 95%CI [0.99\u20131.73],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.058).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ascending aortic dilatation in patients undergoing TAVI for bicuspid AS remains stable in the majority of patients. Factors influencing TAV stent frame geometry and function were identified to be associated with continuous AAo dilatation after TAVI; this should be confirmed in future larger cohort studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-024-02545-9","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T07:22:39Z","timestamp":1726730559000},"page":"375-384","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Incidence and predictors of continued ascending aortic dilatation after TAVI in patients with bicuspid aortic stenosis"],"prefix":"10.1007","volume":"114","author":[{"given":"Yuheng","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif A.","family":"Khokhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pilgrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Mylotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Sammartino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daijiro","family":"Tomii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Fosb\u00f8l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Tamburino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus Fuglsang","family":"Kofoed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Barbanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9674-0278","authenticated-orcid":false,"given":"Ole","family":"De Backer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"issue":"10","key":"2545_CR1","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1001\/jama.2011.1286","volume":"306","author":"HI Michelena","year":"2011","unstructured":"Michelena HI, Khanna AD, Mahoney D et al (2011) Incidence of aortic complications in patients with bicuspid aortic valves. 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