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Thus, 30 patients undergoing TTVI (21 direct annuloplasty and 9 edge-to-edge repair) received cardiopulmonary exercise testing (CPET) and CWRET (at 75% of maximum work rate in the initial CPET) before and 3\u00a0months after TTVI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Patients\u2019 age was 80.5 [74.8\u201382.3] years and 53.3% were female. TR reduction\u2009\u2265\u20092 grades was achieved in 93.3% (TR grade\u2009\u2264\u2009moderate in 83.3%). Echocardiography revealed improved right ventricular (RV) characteristics with decreased RV basal diameter (47.0\u00a0mm [43.0\u201354.3] vs. 41.5\u00a0mm [36.8\u201348.0]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and decreased inferior caval vein diameter. CWRET testing showed a significantly improved SEC (246.5\u00a0s [153.8\u2013416.8] vs. 338.5\u00a0s [238.8\u2013611.8] <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Maximum oxygen uptake showed a positive trend without statistically significant differences (9.9\u00a0ml\/min\/kg [8.6\u201312.4] vs. 11.7\u00a0ml\/min\/kg [9.7\u201313.3]; <jats:italic>p<\/jats:italic>\u2009=\u20090.31). In contrast to the six-minute-walking distance (6MWD), SEC correlated moderately with effective regurgitation orifice area reduction (<jats:italic>r<\/jats:italic>\u2009=\u20090.385; <jats:italic>p<\/jats:italic>\u2009=\u20090.036), increased cardiac output (<jats:italic>r<\/jats:italic>\u2009=\u20090.378; <jats:italic>p<\/jats:italic>\u2009=\u20090.039), and improved QOL (<jats:italic>r<\/jats:italic>\u2009=\u2009387; <jats:italic>p<\/jats:italic>\u2009=\u20090.035).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Improvements in exercise capacity after TTVI mainly occur in the submaximal rather than in the maximal exercise range and correlate with hemodynamic effects and QOL. This may have a methodological impact on assessment of exercise capacity in these patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical abstract<\/jats:title>\n            <jats:p>Improvements in exercise capacity mainly occur in the submaximal (Constant work-rate exercise-time, CWRET) rather than in the maximal exercise range (maximum oxygen consumption, peak <jats:italic>V<\/jats:italic>O<jats:sub>2<\/jats:sub>), and correlate with reduction in tricuspid regurgitation, hemodynamic effects and QOL<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00392-024-02554-8","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T13:02:34Z","timestamp":1728478954000},"page":"261-271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exercise testing in patients with tricuspid regurgitation undergoing transcatheter tricuspid valve intervention"],"prefix":"10.1007","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1822-936X","authenticated-orcid":false,"given":"Muhammed","family":"Ger\u00e7ek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Ivannikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arseniy","family":"Goncharov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Ger\u00e7ek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"M\u00f6rsdorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Kirchner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja K.","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai P.","family":"Friedrichs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Dumitrescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"2554_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.701243","volume":"8","author":"M Ger\u00e7ek","year":"2021","unstructured":"Ger\u00e7ek M, Rudolph V (2021) Secondary tricuspid regurgitation: pathophysiology, incidence and prognosis. 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Volker Rudolph and Tanja K. Rudolph received speaker Honoraria and grants from Abbott and Edwards Lifesciences. The other authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}