{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T09:10:36Z","timestamp":1778490636157,"version":"3.51.4"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Schleswig-Holstein - Campus Kiel"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Res Cardiol"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>LAAO is an interventional, prophylactic treatment to prevent cardioembolic stroke in patients with non-valvular atrial fibrillation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study was to assess gender differences and age-related in-hospital course of all patients undergoing left atrial appendage occlusion (LAAO) in Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Research Data Center of the Federal Statistical Office accessed interrogation of its Diagnosis Related Groups (DRG) statistics database. In a retrospective observational manner, all German in-hospital cases from 2016 to 2022 with a coded LAAO procedure were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LAAO was performed on a total of 40,435 patients, 39.2% of whom were female. The relative frequency of procedures in the German male population over the age of 60 was twice as high as in the German female population. The median age was 78 (IQR: 72\u201382) years. Compared to 28.3% in 2016, in 2022 40.1% of all patients were over 80\u00a0years of age (increased by 152%). Cases of patients over 85\u00a0years of age increased from 7.7 to 11.4% during the same time period. We found an in-hospital death rate for patients\u2009&lt;\u200970, 70\u201375, 80\u201385 and\u2009&gt;\u200985\u00a0years of age of 0.8, 1.0, 1.4\u00a0and 2.2% respectively. Further, we saw significantly higher MACE rates (&lt;\u200975\u00a0years: 4%, 75\u201385\u00a0years: 5%,\u2009&gt;\u200985\u00a0years: 7%) in patients with a higher age. Gender was not significantly associated with a higher rate of in-hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In Germany, LAAO is increasingly performed in older patients with a strong gender imbalance. Age was independently associated with higher in-hospital MACE and mortality rates. This data provides a further basis to balance risks and benefits of LAAO as a preventive procedure and highlights the need for further prospective studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                    <jats:p>Trends in gender, demographics and in-hospital outcomes in a German nationwide analysis on all patients with an LAAO procedure in the years from 2016 to 2022.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00392-024-02586-0","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T11:13:25Z","timestamp":1736248405000},"page":"927-936","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Left atrial appendage occlusion: trends in demographics and in-hospital outcomes\u2014a German nationwide analysis"],"prefix":"10.1007","volume":"115","author":[{"given":"Jakob Christoph","family":"Voran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatim","family":"Seoudy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Leye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Kolbrink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Schulte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Dempfle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derk","family":"Frank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0884-6572","authenticated-orcid":false,"given":"Felix","family":"Kreidel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"2586_CR1","doi-asserted-by":"publisher","first-page":"e1038","DOI":"10.4244\/EIJ-D-22-00627","volume":"18","author":"DR Holmes","year":"2023","unstructured":"Holmes DR, Korsholm K, Rod\u00e9s-Cabau J, Saw J, Berti S, Alkhouli MA (2023) Left atrial appendage occlusion. 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FK has received speaker\u2019s honoraria and consultation fees from Abbott Medical, Inc. The other authors report no conflict of interest in relation to this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}